An anti-counterfeit and authentication method usingtime controlled numeric tokens enabling a secure logistic chain ispresented. Implementation of the method is illustrated with apharmaceutical anti-counterfeit system. The method uses activeRFID technology in combination with product seal. Authenticityis verified by comparing time controlled ID-codes, i.e. numerictokens, stored in RFID tags and by identical numeric tokensstored in a secure database. The pharmaceutical products areprotected from the supplier to the pharmacist, with thepossibility to extend the authentication out to the end customer.The ability of the method is analyzed by discussion of severalpossible scenarios. It is shown that an accuracy of 99.9% tellingthe customer she has an authentic product is achieved by the useof 11-bit ID-code strings.