The aim of the study was to investigate secondary school students´ preferences and experiences towards HIV/AIDS- education. A cross- sectional study was carried out in Dodoma region on five different secondary schools. Data was collected by a self-administered questionnaire, which was completed by 380 informants. The sample was made from the independent variables; gender, school location and school ownership. The result showed that 93 % of the students thought they need more information about HIV/AIDS. Only 51 % of the students felt that they had enough knowledge about HIV/AIDS to protect themselves from being infected by the virus. Half of all the students felt that there is a lack of support from the school to students living with HIV/AIDS. The students selected teachers, parents and doctor or health worker as the key persons in the HIV/AIDS- education. The conclusion is that there is a need of more information about HIV/AIDS among secondary school students. To reach out with the message to the students, the key persons have to interact and struggle towards the same goal. Further research should have a qualitative approach to examine secondary school students´ preferences and experiences towards HIV/AIDS- education.