To perform, new technology-based firms (NTBFs) need to develop value for customers that distinguish them from others in the market. Therefore, the development of novelty-oriented value propositions are important, and may be influenced by several factors. We argue that the propensity to become more novelty-oriented can be influenced by an internal drive to grow (growth orientation) and by external contributions (business networks). Hence, the purpose of this paper is to analyse how business networks and growth orientation effects on the novelty orientation of NTBF value propositions. Based on survey data from 401 NTBFs founded between 2013 and 2015, in the nascent start-up phase novelty-oriented value propositions of NTBFs positively relate to informal (management) networks, as well as founders' attitudes towards growth. Thus, such networks and attitudes from founders should be supported in the very early phases of start-up if novelty orientation is to be preferred as a performance determinant. © 2018 Elsevier Inc.