Healthcare 4.0 (4.0) requires the integration of technological breakthroughs to enable transformational innovation using the Industry 4.0 (I4.0) technology landscape. The study reveals its importance, necessity, relevance, awareness, and implementation for digital transformation. H4.0 is a technological catalyst for accelerating exponential growth by integrating cutting-edge industrial and technological landscapes. It enables gathering data from various healthcare sensors and facilitates human-machine interaction (HMI). The study highlights developing Conceptual Technological Framework 4.0 (CTF4.0), a revolutionized living space for individuals with neurological disorders, particularly multiple sclerosis (MS), strategically positioned within the I4.0 spectrum. The study targets a tailored-made personalized environment that becomes the game-changer for empowering individuals with neurological disorders, relieving symptoms and improving overall well-being through the lens of I4.0 paradigms and meticulous healthcare examination. Addressing irregularities and potential risks associated with stress, fatigue, eye impairment, and memory loss, the authors target a fundamental question of exploiting I4.0 advances to tailor sophisticated environments to the unique needs and preferences of MS patients. The study is well-grounded and has a real-world perspective, as garnered from discussions with MS community members at the Karolinska Institute (KI) in Solna, Stockholm. The CTF4.0 framework ensures that it transcends theoretical constructs and a solution deeply rooted in the lived experiences and perspectives of those it serves. As a result, our study sets the stage for developing a context-aware, personalized, automated smart home health ecosystem tailored explicitly for the neurological disorders community. By granting individuals autonomy over their living environments, we envision spaces that foster independence, alleviate symptoms, and promote overall well-being. © The Author(s)