This paper addresses the design of software for web-based psychosocial care – an increasing and highly relevant societal issue. The paper explores two primary research questions: 1) What design principles should guide the creation of web-based software for online psychological support, and 2) How can design science research facilitate the development and assessment of innovative eHealth solutions? Our research – a tailored DSR approach – was conducted over a 10+ year period within the multi-disciplinary research programme U-CARE. As information systems researchers, we worked as researchers and developers, in tight collaboration with psychologists, economists, medical doctors, nurses, and other key stakeholders. Through this process, we continually reflected and abstracted our experiences into design principles and DSR methodology. In response to the first research question, we introduce a set of design principles for web-based psychosocial support, shaped by the overarching LAME DSR approach. These principles include malleability for adaptability and sustainability, privacy and accountability in online environments, and a focus on stakeholder-specific functionalities like therapist dashboards and smooth authentication processes. In response to the second research question, we present the LAME DSR approach and an informed argument concerning its role in the establishment of a strategic, high-impact research environment. © 2024 by the Association for Information Systems.