Digital automation based on technologies that learn, reason, and act is changing work life. This will inevitably and specifically have implications for knowledge workers and their interplay with "digital technologies." In this paper, we report from a review of IS literature on the implications of digital technology for knowledge work and knowledge workers' competence. We take the knowledge worker's perspective and provide an overview of research and knowledge in the field. The paper is motivated by the need to analyse and relevantly understand the implications of digital automation on work and professions. The contribution is twofold. First, the paper provides an overview of previous research and knowledge on digital automation and knowledge work. Second, it contributes to the conceptualisation/understanding of the challenges and opportunities that digital automation brings to human competence and knowledge work.