The implications of digital automation for knowledge work have sparked intense discussions in society and amongst scholars. This paper provides an overview of information systems (IS) literature on digital automation, knowledge work and work environment implications. We explore digital automation’s implications through a systematic literature review, identifying 179 papers of which 18 were selected as core research studies relevant by inclusion criteria. We provide an overview of IS literature relating to digital automation of knowledge work and the implications for work environment. We show how digital automation is represented and outline positive and negative implications for knowledge workers and organizations. The literature review concludes by pointing out research opportunities that are particularly relevant in progressing IS research on digital automation.