In the transition towards a circular economy and more sustainable business practices, industrial symbiosis (IS) has emerged as a promising strategy to enhance resource efficiency, reduce waste, and generate economic and environmental benefits. Despite its well-documented advantages, IS adoption remains fragmented and inconsistent across industries and regions, raising critical questions about the drivers and barriers that influence its implementation. Energy-based IS, particularly bioenergy production like biogas, exemplifies the complexities of IS adoption. Thus, this study seeks to examine the interplay between drivers and barriers and their effect on adoption and implementation of biogas-based IS on five industrial symbioses, where additional challenges, such as competition with fossil fuels and fragmented supply chains add further complexity. The results show that economic incentives drive industrial biogas symbioses, social factors, especially collaboration and networking, are crucial enablers. A higher number of social barriers, compared to environmental ones, underscores that trust, cooperative competence, and stable relationships are not peripheral but essential. This research contributes to a more comprehensive understanding of biogas IS adoption, offering insights for business managers, policymakers, and sustainability practitioners seeking to advance IS as a scalable strategy for circular economy transitions.