A microfluidic platform for SAXS measurements of liquid samplesShow others and affiliations
2022 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]
Small-angle X-ray scattering (SAXS) is a technique that can measure the size and shape of small particles such as proteins and nanoparticles using X-rays. At MAX IV, we are developing a microfluidic sample delivery platform to measure liquid samples containing proteins under flow using SAXS. One of the main advantages of using microfluidics is that the sample is continuously flowing, thus minimizing the risk of radiation damage as the sample is continuously refreshed. Other advantages include low sample volume and the possibility to study dynamic processes, e.g. mixing. To obtain good SAXS signals, the X-ray properties of the chip material are essential. The microfluidic chip must have low attenuation of X-rays, low background scattering, and high resistance to X-ray-induced damage, and preferably be low cost and easy to fabricate. In this work, we have evaluated the performance of two different polymer microfluidic chips for SAXS measurements.
Place, publisher, year, edition, pages
2022.
National Category
Subatomic Physics
Identifiers
URN: urn:nbn:se:hh:diva-47516OAI: oai:DiVA.org:hh-47516DiVA, id: diva2:1686139
Conference
Swedish Microfluidics in Life Science (SMILS) 2022, Uppsala, June 1-2, 2022
Projects
AdaptoCell
Funder
Swedish Foundation for Strategic Research, ITM-03752022-08-082022-08-082025-10-01Bibliographically approved