OBJECTIVES: The STarT Back screening Tool (SBT) captures patients with low back pain (LBP) at risk of worse prognosis. However, the SBT does not include assessment of multisite and chronic widespread pain (MS-CWP). The aim was to study the differences in prognostic factors in patients with LBP classified according to SBT or SBT in combination with MS-CWP, and the 1-year outcome regarding visits to physiotherapist and sickness absence, in relation to risk scorings.

METHODS: In this 1-year prospective study, adults (18-67 years) seeking care for LBP in primary care were classified into three prognostic risk groups (low, medium, high), using SBT only and using a combined screening tool (SBT and MS-CWP). Differences in prognostic factors at baseline, and outcome in terms of number of physiotherapist visits and sickness absence the year after inclusion were compared for risk groups derived by the two methods.

RESULTS: Eighty-four patients (61% women) were included in the study. According to SBT alone, 19 were classified as low risk, 48 as medium risk, and 17 as high risk. When using the combined screening tool, additionally seven patients from the medium risk group were classified as high risk. Patients classified as high risk by SBT only or by the combined screening tool showed similar statistically significant worse mental health, health status, kinesiophobia, physical function, and sleep, as compared to the low-risk group. There were no differences in visits to physiotherapist and sickness absence between the risk groups for neither of the tools.

CONCLUSION: The combined screening tool resulted in more patients being classified as high risk than with SBT alone. The three risk groups identified either by SBT alone or by the combined screening tool differed significantly on all investigated prognostic factors, suggesting that including MS-CWP to the SBT captures more patients at risk.

© 2025 the author(s), published by De Gruyter

Background: Knee pain is often an early sign of knee osteoarthritis (KOA). Physical activities (PA) constitute the recommended regime to those affected. However, knee-loading PA at work is linked to an increased risk for KOA. The primary aim of this study was to investigate associations between knee pain and accelerometer-measured knee-loading PA, at work and leisure respectively. The secondary aim was to investigate knee-related problems in relation to self-reported physical effort at work.

Methods: This cross-sectional study included 107 working participants (aged 30-67) with knee pain. Knee pain was evaluated using the Knee Injury and Osteoarthritis Outcome Scale (KOOS), subscale Pain. Knee-loading PA (including daily steps, time in upright position, stair walking), and sitting/lying were measured by accelerometer for one week. Each knee-loading PA was analysed separately for the measurement periods: (1) total period, (2) time at work, and (3) leisure on workdays. Knee-related problems were evaluated by the KOOS subscales Symptoms, Activities of Daily Living, Function in Sport and Recreation, and Quality of Life. Analyses were made with linear regression, and stratified by high or low self-reported physical effort at work.

Results: Participants with more knee pain walked on average fewer steps per day, and spent less time in an upright position during leisure on workdays, unstandardized coefficient (β) = 0.001, p = 0.044, β = 0.075, p = 0.001 respectively, i.e. spent less time in knee-loading PA. The associations were stronger for those reporting high physical effort at work, β = 0.116, p = 0.016. Participants with high physical effort at work rated their (knee-related) quality of life worse. There were no associations between knee pain and knee-loading PA during work hours.

Conclusions: Participants with more knee pain were less physically active during leisure, with stronger associations among those with higher physical effort at work. Those reporting high physical effort at work had worse (knee-related) quality of life compared to participants reporting low effort at work. This highlights the importance of taking knee-loading PA at work and leisure into account when recommending exercise regimes to individuals with knee pain. © 2025. The Author(s).

Tyngdtäcke har använts inom vården som ett icke-farmakologiskt behandlingsalternativ. Evidens har dock saknats om effekter av tyngdtäcke på sömnen. En crossover randomiserad kontrollerad studie har genomförts för att utvärdera effekten av tyngdtäcke på sömnbesvär hos barn 6-14 år med ADHD. Resultatet visade på ökad total sömntid, ökad sömneffektivitet och minskad tid i vakenhet under natten, men ingen skillnad i insomning vid användning av tyngdtäcke jämfört med ett lättare kontrolltäcke. Föräldrarna rapporterade att barnens sömnproblem minskade. Barnen rapporterade att sömnkvalitén ökade, däremot sågs ingen skillnad i självrapporterade sömnproblem vid användning av tyngdtäcke jämfört med ett kontrolltäcke. © 2025 Maria Lönn, Katarina Aili, Petra Svedberg, Jens Nygren, Håkan Jarbin, Ingrid Larsson.

Purpose: The present study aimed to provide insight into how adult survivors describe their experiences concerning health, lifestyle, and quality of life, considering the long-term impact of treatment for acute lymphoblastic leukemia (ALL) and allogeneic HSCT (a-HSCT) during their childhood. The research question focused on understanding the long-term effects of these treatments on survivors’ lives.

Methods: A descriptive and qualitative design was employed. Participants included eighteen individuals who had undergone a-HSCT for childhood ALL and were part of a national cohort diagnosed between 1985 and 2007. Data were collected through semi-structured telephone interviews, with questions assessing current health, quality of life, and the impact of childhood cancer experiences on their lifestyle. Interviews were transcribed verbatim and analyzed using an inductive approach and thematic analysis to identify key themes.

Results: The analysis revealed two overarching themes: “Challenges and adaptation in long-term survivorship” and “Uncertainty and doubts surrounding parenthood,” with five subthemes. Participants described ongoing existential struggles, both internal (maintaining health despite complications) and external (social participation difficulties). They also faced emotional distress related to infertility and doubts about their suitability as parents.

Conclusions: The study highlights the profound personal challenges faced by childhood ALL survivors treated with a-HSCT. These include managing long-term health complications and existential issues. Support for these individuals should be personalized, addressing medical, emotional, and existential needs to enhance their quality of life. Healthcare professionals at long-term follow-up clinics must address not only the medical but also the emotional and existential challenges faced by adult survivors of childhood cancer to improve their overall quality of life. © 2025 The Authors

Background: Parents’ perceptions of children’s sleep problems when using a weighted blanket could enhance the understanding of challenges faced by families with ADHD and sleep problems. This is in alignment with a client-centred approach. Acknowledging, what parents perceive as a problem in a family context.

Aim: To explore changes in parents’ perceptions of their children’s sleep problems before and after participation in a sleep intervention with weighted blankets.

Methods: Children with ADHD (n = 45) aged 6–14 participated in a sleep intervention with weighted blankets. Data-collection (baseline + 16-week) using the Children’s Sleep Habits Questionnaire.

Results: Common sleep problems, such as bedtime resistance, daytime sleepiness, sleep onset delay, and sleep duration, were reported to have improved in 50–75% of the children after using a weighted blanket, according to their parents. Changes were seen also for the less commonly reported parasomnias and nightly awakenings, and these problems were rarely perceived as persistent.

Conclusions: Reported improvements covered various sleep domains, though some sleep issues persisted. Future evaluation of the effects of weighted blanket should assess multiple dimensions of sleep, before and after use.

Significance: The client-centred approach, including parents’ perceptions of children’s sleep problems, is important in the evaluation of weighted blankets for children with ADHD. © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Background: Acute lymphoblastic leukemia (ALL) is the most prevalent childhood malignancy. To improve long-term health-related quality of life (HRQOL) in adult survivors of childhood ALL, more longitudinal studies are needed to assess outcomes and risk factors throughout treatment and survivorship. The aim of this study was to examine the long-term changes in HRQOL, self-efficacy, and social support among adult survivors of childhood ALL and to explore the temporal relationship between HRQOL, self-efficacy, and social support. Procedure: The study includes 148 adult childhood ALL survivors who responded to a questionnaire assessing HRQOL (SF36), self-efficacy (General Self-Efficacy Scale, GSE), and quantitative and qualitative social support (AVSI and AVAT in SS13) in 2012 and 2021. Changes in the HRQOL, GSE, and social support were calculated using paired t-tests. Bayesian path models were specified, and separate models were estimated for each relationship between GSE and AVSI, and AVAT and HRQOL. Cross-sectional associations, autoregressive effects within constructs over time, and cross-lagged effects between two variables over time were specified within each model. Results: The mean of six of the eight HRQOL dimensions, as well as quantitative and qualitative social support, deteriorated during the 9-year follow-up. Self-efficacy was unchanged. Temporal positive relationships were found between baseline GSE and the HRQOL dimension of social functioning, as well as between social support and the HRQOL dimensions of physical functioning, vitality, and mental health at follow-up. Conclusion: The findings highlight the importance of self-efficacy and social support as potential buffering factors for HRQOL in adult survivors of childhood ALL over time. © 2025 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC.

Purpose: Adults who had acute lymphoblastic leukaemia (ALL) as children and were treated with allogeneic hematopoietic stem cell transplantation (aHSCT) may have been affected in their lives due to several long-term complications. From a clinical point of view, it is of interest to study how survivors describe their perceptions of their childhood today. The aim was therefore to describe how adults perceived their childhood and the influences of being treated for ALL with aHSCT as a child.

Method: Semi-structured telephone interviews were undertaken with 18 adults who had been treated for childhood ALL with aHSCT and were included in a national cohort of childhood ALL survivors, diagnosed between 1985 and 2007 at an age between 0 and 17 years. A phenomenographic analysis was used.

Results: Three categories emerged: Feeling different, Feeling security and Feeling guilty. The informants felt that they had been different from other children but had felt security with the healthcare professionals and in care. They felt guilty because both their siblings’ and parents’ lives had been affected, but at the same time many perceived that they and their family members had become closer to one another.

Conclusions: The results emphasised that adults who had been treated for childhood ALL with aHSCT were affected both in negative and positive ways during their childhood. This indicates the importance for early psychosocial care interventions directed to children during their treatment, but also the need for person-centred psychological care in long-term outpatient clinics. © 2024 The Authors. Published by Elsevier Ltd.

Study objectives: To examine differences in sample characteristics and longitudinal sleep outcomes according to weighted blanket adherence.

Methods: Children with attention-deficit/hyperactivity disorder (ADHD) (n =94), mean age 9.0 (sd 2.2, range 6-14) participated in a 16-week sleep intervention with weighted blankets (WB). Children were classified as WB adherent (use of WB ≥ 4 nights/week) or non-adherent (use of WB ≤ 3 nights/week). Changes in objectively measured sleep by actigraphy, parent-reported sleep problems (Children's Sleep Habits Questionnaire (CSHQ)) and child-reported Insomnia Severity Index (ISI) were evaluated according to adherence with mixed effect models. Gender, age, and ADHD subtype were examined as potential moderators.

Results: Children adherent to WBs (48/94) showed an early response in sleep outcomes and an acceptance of the WB after four weeks of use as well as a decrease in parent- (CSHQ) (-5.73, P = .000) and child-reported sleep problems (ISI) (-4.29, P = .005) after 16 weeks. The improvement in sleep was larger among WB adherent vs. non-adherent (between-group difference: CSHQ: -2.09, P = .038; ISI: -2.58, P =.007). Total sleep time was stable for children adherent to WB but decreased for non-adherent (between-group difference: +16.90, P = .019).

Conclusions: An early response in sleep and acceptance of the WB predicted later adherence to WBs. Improvements in sleep were more likely among WB adherents vs. non-adherents. Children with ADHD may thus benefit from using WBs to handle their sleep problems.

© 2024 American Academy of Sleep Medicine

Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood, but the prognosis has remarkably improved over the last 50 years in high-income countries, and thus, there is a focus on long-term health outcomes following survival and how to best provide health care support to adult long-term survivors of childhood ALL to prevent and handle potential health problems. Digital health interventions are promising to deliver feasible health promotion and prevention programs. This is particularly relevant for ensuring long-term follow-up in cases where continuous contact with oncology care may be disrupted. Moreover, these interventions are beneficial in reaching geographically dispersed target groups and overcoming the time constraints of everyday life that often hinder participation in such programs. Objective: This study aimed to fill the gaps in existing research on adult long-term survivors of childhood ALL and provide formative data that can inform the development of formalized follow-up services designed to meet the needs of these survivors in ways that align with their preferences for digital health interventions. Methods: In this cross-sectional national study, adult survivors (aged ≥18 years) of childhood ALL for over 10 years after diagnosis were compared to their siblings in terms of mental and physical health-related factors, including sleep, stress, anxiety, and depression (Depression Anxiety and Stress Scale 21 [DASS-21]); several dimensions of fatigue (Multidimensional Fatigue Inventory 20 [MFI-20]); work ability (Work Ability Index); chronic pain; and prevalences of diabetes, cardiovascular disease, headache or migraine, and rheumatic disease. Results: Overall, 426 of 855 eligible ALL survivors responded (mean age 30.9, SD 7.7 years), and they participated at an average of 24 (SD 6.9) years after ALL diagnosis. Siblings (n=135; mean age 31.5, SD 7.7 years) acted as controls. Sleep quality, sleep quantity, and mean work ability scores were significantly lower, and physical fatigue, reduced motivation, and reduced activity scores were higher in ALL survivors than in siblings. There were no significant differences between the groups in terms of BMI and prevalence of chronic pain, depression, anxiety, or stress. Physical and psychological complications were more frequent among adult ALL survivors who had received hematopoietic stem cell transplantation (HSCT) than among those who had not received HSCT. Conclusions: Our nationwide cross-sectional study addressed the scarcity of knowledge regarding the self-reported health outcomes of adult long-term survivors of childhood ALL. We highlighted significant disparities within this population and emphasized the potential of comprehensive digital interventions that target vitality, sleep quality, fatigue, and psychosocial well-being to enhance well-being and bolster the capacity for managing chronic health conditions in this target group. Such an intervention would align with the needs of this target group, which is a prerequisite for successfully incorporating technology into the daily lives of survivors of childhood ALL. © 2024 JMIR Publications Inc.. All rights reserved.

Objectives: The aim was to study the development of radiographic knee osteoarthritis (RKOA) in individuals with knee pain over 2 years, and the associations between radiographic changes and baseline variables.

Design: Longitudinal cohort study.

Participants and setting: This study is part of the Halland Osteoarthritis cohort. The included 178 individuals, aged 30-67, had knee pain, without cruciate ligament injury or radiographic findings and 67% were women. The presence of RKOA was defined as Ahlbäck score of ≥1 in ≥1 knee. (Ahlbäck grade 1: joint space narrowing in the tibiofemoral joint <3 mm). Diagnosis of clinical KOA was based on the clinical guideline from the National Institute for Health and Care Excellence (NICE). Knee injury and Osteoarthritis Outcome Score (KOOS), pain intensity, physical function, body mass index (BMI) and visceral fat area (VFA) were measured. Associations to RKOA were analysed with logistic regression (OR).

Results: In all, 13.8% (n=24) developed RKOA in 2 years whereof all had clinical KOA at baseline, as defined by NICE. Deterioration to RKOA was significantly associated with higher BMI, OR 1.119 (95% CI 1.024 to 1.223; p=0.013), and VFA, 1.008 (95% CI 1.000 to 1.016; p=0.049), worse knee pain intensity, 1.238 (95% CI 1.028 to 1.490; p=0.024), worse scores for KOOS Pain, 0.964 (95% CI 0.937 to 0.992; p=0.013) and KOOS Symptoms, 0.967 (95% CI 0.939 to 0.996; p=0.027), KOOS Activities of daily living 0.965 (95% CI 0.935 to 0.996; p=0.026) and KOOS Quality of Life 0.973 (95% CI 0.947 to 0.999; p=0.044), at baseline.

Conclusions: One out of seven individuals with clinical KOA developed RKOA in only 2 years. Baseline variables associated with RKOA after 2 years may possibly be detected early by using the NICE guideline, assessment of obesity and self-reported data of symptoms to support first-line treatment: education, exercise and weight control. © Author(s) (or their employer(s)) 2024.