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  • 51.
    Samuelsson, Jim
    et al.
    BioBridge Computing, Lund, Sweden.
    Dalevi, Daniel
    BioBridge Computing, Lund, Sweden.
    Aim, Rikard
    Lund Graduate School of Biomedical Sciences/Biomol. Res., Lund, Sweden.
    Rögnvaldsson, Thorsteinn
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Potthast, Frank
    AstraZeneca R and D, Mölndal, Sweden.
    PIUMS® - A new algorithm for protein identification using peptide fingerprints2002Inngår i: Proceedings: 50th ASMS Conference on Mass Spectrometry and Allied Topics, June 2-6, 2002, Orlando, Florida., Santa Fe: ASMS , 2002, s. 783-784Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Piums®, a new protein identification tool for peptide fingerprints, is presented. Piums includes both a peak extraction tool (Pepex®) and a new protein scoring algorithm (Piped®). The basic ideas underlying the scoring algorithm are presented and it is demonstrated on some real sample spectra. It is shown, using simulated peak lists, how the scoring performance varies with contamination levels and protein sequence coverage, and that there is a boundary for when scoring is possible. Piums is fully scriptable and modularised. Each individual module can be used by itself, with input and output in XML format, to e.g. include it in an analysis chain. Piums is benchmarked against the Mascot software from Matrix Science LLC, The results indicate that Piums is more precise than the Mascot score, and about 5-10% more efficient than Mascot for real peak lists, for the same level of false positives.

  • 52.
    Samuelsson, Jim
    et al.
    Genedata GmbH, Lena-Christ-Strasse 50, 82152 Martinsried, Germany.
    Dalevi, Daniel
    Computing Science, Chalmers University of Technology, SE-412 96 Göteborg.
    Levander, Fredrik
    Department of Protein Technology, Lund University, Sölvegatan 33A.
    Rögnvaldsson, Thorsteinn
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), Intelligenta system (IS-lab).
    Modular, scriptable and automated analysis tools for high-throughput peptide mass fingerprinting2004Inngår i: Bioinformatics, ISSN 1367-4803, E-ISSN 1367-4811, Vol. 20, nr 18, s. 3628-3635Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A set of new algorithms and software tools for automatic protein identification using peptide mass fingerprinting is presented. The software is automatic, fast and modular to suit different laboratory needs, and it can be operated either via a Java user interface or called from within scripts. The software modules do peak extraction, peak filtering and protein database matching, and communicate via XML. Individual modules can therefore easily be replaced with other software if desired, and all intermediate results are available to the user. The algorithms are designed to operate without human intervention and contain several novel approaches. The performance and capabilities of the software is illustrated on spectra from different mass spectrometer manufacturers, and the factors influencing successful identification are discussed and quantified.

  • 53.
    Svensson, Magnus
    et al.
    Volvo Technology, 405 08 Göteborg, Sweden.
    Byttner, Stefan
    Högskolan i Halmstad, Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE), Halmstad Embedded and Intelligent Systems Research (EIS), Intelligenta system (IS-lab).
    Rögnvaldsson, Thorsteinn
    Högskolan i Halmstad, Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE), Halmstad Embedded and Intelligent Systems Research (EIS), Intelligenta system (IS-lab).
    Self-organizing maps for automatic fault detection in a vehicle cooling system2008Inngår i: 4th International IEEE Conference Intelligent Systems, 2008. IS '08, Piscataway, N.J.: IEEE Press, 2008, s. 24-8-24-12Konferansepaper (Fagfellevurdert)
    Abstract [en]

    A telematic based system for enabling automatic fault detection of a population of vehicles is proposed. To avoid sending huge amounts of data over the telematics gateway, the idea is to use low-dimensional representations of sensor values in sub-systems in a vehicle. These low-dimensional representations are then compared between similar systems in a fleet. If a representation in a vehicle is found to deviate from the group of systems in the fleet, then the vehicle is labeled for diagnostics for that subsystem. The idea is demonstrated on the engine coolant system and it is shown how this self-organizing approach can detect varying levels of clogged radiator.

    Fulltekst (pdf)
    FULLTEXT01
  • 54.
    Svensson, Magnus
    et al.
    Volvo Technology, Sweden.
    Byttner, Stefan
    Högskolan i Halmstad, Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE), Halmstad Embedded and Intelligent Systems Research (EIS), Intelligenta system (IS-lab).
    Rögnvaldsson, Thorsteinn
    AASS Örebro University, Sweden.
    Vehicle Diagnostics Method by Anomaly Detection and Fault Identification Software2009Inngår i: SAE international journal of passenger cars : electronic and electrical systems, ISSN 1946-4614, Vol. 2, nr 1, s. 352-358Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A new approach is proposed for fault detection. It builds on using the relationships between sensor values on vehicles to detect deviating sensor readings and trends in the system performance. However, in contrast to previous approaches based on such sensor relations, our approach uses a fleet of vehicles to define the normal conditions and relations. The relationships between the sensors are also determined automatically in a self-organized way on each vehicle, i.e. no off-line modeling is required. The proposed method is the first step in a remote diagnostics and maintenance service where error detection is done automatically, followed by a download of special purpose diagnostics software for the particular subsystem where the possible fault was detected.

  • 55.
    Svensson, Magnus
    et al.
    Volvo Technology.
    Forsberg, Magnus
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Byttner, Stefan
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Rögnvaldsson, Thorsteinn
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Deviation Detection by Self-Organized On-Line Models Simulated on a Feed-Back Controlled DC-Motor2009Inngår i: Proceeding Intelligent Systems and Control (ISC 2009) / [ed] M.H. Hamza, Cambridge, Mass.: ACTA Press, 2009Konferansepaper (Fagfellevurdert)
    Abstract [en]

    A new approach to improve fault detection is proposed. The method takes benefit of using a population of systems to dynamically define a norm of how the system works. The norm is derived from self-organizing algorithms which generate a low dimensional representation of how selected feature data are correlated. The feature data is selected from the state variables and from the control signals. The self-organizing method and limited number of feature signals enable fast deviation detection and low computational footprint on each system to be analyzed. The comparison analysis between the systems is performed at a service centre, to where the low-dimensional representations of the systems are transmitted. The method is demonstrated on a simulated DC-motor and the results are promising for deviation detection.

  • 56.
    Svensson, Magnus
    et al.
    Volvo Technology.
    Rögnvaldsson, Thorsteinn
    Högskolan i Halmstad, Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE), Halmstad Embedded and Intelligent Systems Research (EIS), Intelligenta system (IS-lab).
    Byttner, Stefan
    Högskolan i Halmstad, Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE), Halmstad Embedded and Intelligent Systems Research (EIS), Intelligenta system (IS-lab).
    West, Martin
    Volvo Technology.
    Andersson, Björn
    Volvo Technology.
    Unsupervised deviation detection by GMM - A simulation study2011Inngår i: SDEMPED 2011: 8th IEEE Symposium on Diagnostics for Electrical Machines, Power Electronics & Drives : September 5-8, 2011, Bologna, Italy, Piscataway, N.J.: IEEE Press, 2011Konferansepaper (Fagfellevurdert)
    Abstract [en]

    A new approach to improve fault detection of electrical machines is proposed. The increased usage of electrical machines and the higher demands on their availability requires new approaches to fault detection. In this paper we demonstrate that it is possible to detect a certain fault on a PMSM (Permanent Magnet Synchronous Machine) by using multiple similar motors, or a single motor, to build a norm of expected behavior by monitoring signal relations. This means that the machine is monitored in an unsupervised way. Four levels of an increased temperature in the rotor magnets have been investigated. The results are based on simulations and the signals used (for relation measurements) are available in a real motor installation. The method shows promising results in detecting two of the temperature faults. © 2011 IEEE.

  • 57.
    Wickström, Nicholas
    et al.
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Byttner, Stefan
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Hellring, Magnus
    Volvo Technology Corporation, Gothenburg, Sweden.
    Rögnvaldsson, Thorsteinn
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Neural networks for extracting the pressure peak position from the ion current2004Inngår i: Virtual sensing of combustion quality in SI engines using the ion current, Göteborg: Chalmers tekniska högskola , 2004, s. 95-110Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 58.
    You, Liwen
    et al.
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Garwicz, Daniel
    Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.
    Rögnvaldsson, Thorsteinn
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Comprehensive Bioinformatic Analysis of the Specificity of Human Immunodeficiency Virus Type 1 Protease2005Inngår i: Journal of Virology, ISSN 0022-538X, E-ISSN 1098-5514, Vol. 79, nr 19, s. 12477-12486Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Rapidly developing viral resistance to licensed human immunodeficiency virus type 1 (HIV-1) protease inhibitors is an increasing problem in the treatment of HIV-infected individuals and AIDS patients. A rational design of more effective protease inhibitors and discovery of potential biological substrates for the HIV-1 protease require accurate models for protease cleavage specificity. In this study, several popular bioinformatic machine learning methods, including support vector machines and artificial neural networks, were used to analyze the specificity of the HIV-1 protease. A new, extensive data set (746 peptides that have been experimentally tested for cleavage by the HIV-1 protease) was compiled, and the data were used to construct different classifiers that predicted whether the protease would cleave a given peptide substrate or not. The best predictor was a nonlinear predictor using two physicochemical parameters (hydrophobicity, or alternatively polarity, and size) for the amino acids, indicating that these properties are the key features recognized by the HIV-1 protease. The present in silico study provides new and important insights into the workings of the HIV-1 protease at the molecular level, supporting the recent hypothesis that the protease primarily recognizes a conformation rather than a specific amino acid sequence. Furthermore, we demonstrate that the presence of 1 to 2 lysine residues near the cleavage site of octameric peptide substrates seems to prevent cleavage efficiently, suggesting that this positively charged amino acid plays an important role in hindering the activity of the HIV-1 protease.

    Fulltekst (pdf)
    fulltext
  • 59.
    You, Liwen
    et al.
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), Intelligenta system (IS-lab).
    Rögnvaldsson, Thorsteinn
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), Intelligenta system (IS-lab).
    Almost Linear Biobasis Function Neural Networks2007Inngår i: The 2007 International Joint Conference on Neural Networks: IJCNN 2007 conference proceedings : August 12-17, 2007, Resaissance Orlando Resort, Orlando, Florida, USA, Piscataway, N.J.: IEEE Press, 2007, s. 1774-1778Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    An analysis of biobasis function neural networks is presented, which shows that the similarity metric used is a linear function and that bio-basis function neural networks therefore often end up being just linear classifiers in high dimensional spaces. This is a consequence of four things: the linearity of the distance measure, the normalization of the distance measure, the recommended default values of the parameters, and that biological data sets are sparse.

    Fulltekst (pdf)
    FULLTEXT01
  • 60.
    Åstrand, Björn
    et al.
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Bouguerra, Abdelbaki
    Learning Systems Lab (AASS), Dept. of Technology, Örebro University, Sweden.
    Andreasson, Henrik
    Learning Systems Lab (AASS), Dept. of Technology, Örebro University, Sweden.
    Lilienthal, Achim J.
    Learning Systems Lab (AASS), Dept. of Technology, Örebro University, Sweden.
    Rögnvaldsson, Thorsteinn
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    An autonomous robotic system for load transportation2009Inngår i: Program and Abstracts, Fourth Swedish Workshop on Autonomous Robotics, SWAR'09 / [ed] Lars Asplund, Västerås: Mälardalen University , 2009, s. 56-57Konferansepaper (Annet vitenskapelig)
  • 61.
    Rögnvaldsson, Thorsteinn ()
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), CAISR Centrum för tillämpade intelligenta system (IS-lab).
    Coquand, Catarina
    Högskolan i Halmstad.
    CAISR Center for Applied Intelligent Systems Research: Annual Report 20192020Annet (Annet (populærvitenskap, debatt, mm))
    Fulltekst (pdf)
    fulltext
12 51 - 61 of 61
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