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  • 51. Ribbestam, Martin
    Trampfrekvensens inverkan på energetisk kostnad under submaximalt arbete på cykel: En litteraturstudie2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 52.
    Sardar, Samra
    et al.
    University of Copenhagen, Copenhagen, Denmark.
    Alish, Kerr
    University of Copenhagen, Copenhagen, Denmark & Pfizer Pharmaceuticals, Dublin, Ireland.
    Vaartjes, Daniëlle
    University of Copenhagen, Copenhagen, Denmark & Karolinska Institute, Stockholm, Sweden.
    Voetmann, Mathilde Emilie
    University of Copenhagen, Copenhagen, Denmark & Biogen Denmark A/S, Hillerød, Denmark.
    Moltved, Emilie Riis
    University of Copenhagen, Copenhagen, Denmark & QuintilesIMS, North Carolina, USA.
    Andersson, Åsa
    Halmstad University, School of Business, Engineering and Science, The Rydberg Laboratory for Applied Sciences (RLAS). University of Copenhagen, Copenhagen, Denmark.
    A novel candidate for genetic control of Collagen Induced Arthritis is involved in transcriptional regulation of B-cell proliferation2017Conference paper (Other academic)
  • 53.
    Sardar, Samra
    et al.
    University of Copenhagen, Copenhagen, Denmark & Nordic Bioscience A/S, Copenhagen, Denmark.
    Kanne, Katrine
    University of Copenhagen, Copenhagen, Denmark & Novartis International AG, Copenhagen, Denmark.
    Andersson, Åsa
    Halmstad University, School of Business, Engineering and Science, The Rydberg Laboratory for Applied Sciences (RLAS). University of Copenhagen, Copenhagen, Denmark.
    Analysis of polymorphisms in the mediator complex subunit 13-like (Med13L) gene in the context of immune function and development of experimental arthritis2018In: Archivum Immunologiae et Therapiae Experimentalis, ISSN 0004-069X, E-ISSN 1661-4917, Vol. 66, no 5, p. 365-377Article in journal (Refereed)
    Abstract [en]

    The Mediator complex subunit 13-like (MED13L) protein is part of the multi-protein mediator complex and plays an important role in gene transcription. Polymorphisms in the MED13L gene have been linked to congenital heart anomalies and intellectual disabilities. Despite recent evidence of indirect links of MED13L to cytokine release and inflammation, impact of genetic variations in MED13L on immune cells remains unexplored. The B10.RIII and RIIIS/J mouse strains vary in susceptibility to induced experimental autoimmune disease models. From sequencing data of the two mouse strains, we identified six polymorphisms in the coding regions of Med13l. By using congenic mice, we studied the effect of these polymorphisms on immune cell development and function along with susceptibility to collagen-induced arthritis, an animal model for Rheumatoid Arthritis (RA). Combining in vivo disease data, in vitro functional data, and computational analysis of the reported non-synonymous polymorphisms, we report that genetic polymorphisms in Med13l do not affect the immune phenotype in these mice and are predicted to be non-disease associated. © The Author(s) 2018

  • 54.
    Sardar, Samra
    et al.
    Nordic Bioscience A/S, Copenhagen, Denmark.
    Kerr, Alish
    Nuritas, Dublin, Ireland.
    Vaartjes, Daniëlle
    Karolinska Institutet, Stockholm, Sweden.
    Moltved, Emilie Riis
    IQVIA Denmark, Copenhagen, Denmark.
    Karosiene, Edita
    Novo Nordisk A/S, Copenhagen, Denmark.
    Gupta, Ramneek
    Technical University of Denmark, Lyngby, Denmark.
    Andersson, Åsa
    Halmstad University, School of Business, Engineering and Science, The Rydberg Laboratory for Applied Sciences (RLAS).
    The oncoprotein TBX3 is controlling severity in experimental arthritis2019In: Arthritis Research & Therapy, ISSN 1478-6354, E-ISSN 1478-6362, Vol. 21, no 1, article id 16Article in journal (Refereed)
    Abstract [en]

    Background: Development of autoimmune diseases is the result of a complex interplay between hereditary and environmental factors, with multiple genes contributing to the pathogenesis in human disease as well as in experimental models for disease. The T-box protein 3 is a transcriptional repressor essential during early embryonic development, in the formation of bone and additional organ systems, and in tumorigenesis.

    Methods: With the aim to find novel genes important for autoimmune inflammation, we have performed genetic studies of collagen-induced arthritis, a mouse experimental model for Rheumatoid Arthritis.

    Results: We show that a small genetic fragment on mouse chromosome 5, including Tbx3 and three additional protein-coding genes, is linked to severe arthritis and high titers of anti-collagen antibodies. Gene expression studies have revealed differential expression of Tbx3 in B-cells, where low expression was accompanied by a higher B-cell response upon B-cell receptor stimulation in vitro. Furthermore, we show that serum TBX3 levels rise concomitantly with increasing severity of CIA.

    Conclusions: From these results, we suggest that TBX3 is a novel factor important for the regulation of gene transcription in the immune system and that genetic polymorphisms, resulting in lower expression of Tbx3, are contributing to a more severe form of collagen-induced arthritis and high titers of autoantibodies. We also propose TBX3 as a putative diagnostic biomarker for rheumatoid arthritis.

  • 55.
    Sardar, Samra
    et al.
    University of Copenhagen, Copenhagen, Denmark.
    Vartjes, Daniëlle
    Karolinska Institute, Stockholm, Sweden.
    Voetmann, Mathilde
    University of Copenhagen.
    Andersson, Åsa
    University of Copenhagen, Copenhagen, Denmark.
    Novel candidates for genetic control of Collagen INduced Arthritis are involved in transcriptional regulation of B-cell proliferation2017Conference paper (Refereed)
  • 56.
    Schmelz, M.
    et al.
    Department of Physiology and Experimental Pathophysiology, University of Erlangen/Nuremberg, D-91054 Erlangen, Germany; Department of Anesthesiology, Medical Faculty Mannheim, University of Heidelberg, 61087 Mannheim, Germany.
    Schmidt, R.
    Department of Clinical Neurophysiology, University of Uppsala, S-75185 Uppsala, Sweden.
    Weidner, C.
    Department of Physiology and Experimental Pathophysiology, University of Erlangen/Nuremberg, D-91054 Erlangen, Germany.
    Hilliges, Marita
    Department of Basic Oral Sciences, Karolinska Institute, S-14104 Huddinge, Sweden.
    Torebjörk, H. E.
    Department of Clinical Neurophysiology, University of Uppsala, S-75185 Uppsala, Sweden.
    Handwerker, Hermann Otto
    Department of Physiology and Experimental Pathophysiology, University of Erlangen/Nuremberg, D-91054 Erlangen, Germany.
    Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens2003In: Journal of Neurophysiology, ISSN 0022-3077, E-ISSN 1522-1598, Vol. 89, no 5, p. 2441-2448Article in journal (Refereed)
    Abstract [en]

    Vasoneuroactive substances were applied through intradermal microdialysis membranes and characterized as itch- or pain-inducing in psychophysical experiments. Histamine always provoked itching and rarely pain, capsaicin always pain but never itching. Prostaglandin E[2] (PGE[2]) led preferentially to moderate itching. Serotonin, acetylcholine, and bradykinin induced pain more often than itching. Subsequently the same substances were used in microneurography experiments to characterize the sensitivity profile of human cutaneous C-nociceptors. The responses of 89 mechanoresponsive (CMH, polymodal nociceptors), 52 mechanoinsensitive, histamine-negative (CMi[H][i][s][-]), and 24 mechanoinsensitive, histamine-positive (CMi[H][i][s][+]) units were compared. CMi[H][i][s][+] units were most responsive to histamine and to PGE[2] and less to serotonin, ACh, bradykinin, and capsaicin. CMH units (polymodal nociceptors) and CMi[H][i][s] units showed significantly weaker responses to histamine, PGE[2], and acetylcholine. Capsaicin and bradykinin responses were not significantly different in the two classes of mechano-insensitive units. We conclude that CMi[H][i][s][+]units are "selective," but not "specific" for pruritogenic substances and that the pruritic potency of a mediator increases with its ability to activate CMi[H][i][s][+] units but decreases with activation of CMH and CMi[H][i][s] units.

  • 57.
    Silwer, Louise
    et al.
    Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI).
    Johansson, Eskil
    Laurentius Centre, Falkenberg, Sweden.
    Stålsby Lundborg, Cecilia
    Karolinska Institute, Department of Public Health Sciences, Stockholm Sweden .
    Drug prescribing in public primary care centres: Results from prescription studies 1988-1997 in the county of Halland, Sweden2002In: Scandinavian Journal of Primary Health Care, ISSN 0281-3432, E-ISSN 1502-7724, Vol. 20, no 4, p. 236-241Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To present the prescribing patterns of general practitioners (GPs) at public primary care centres (PPCCs) in Halland, a county in the south-west of Sweden. GP share of the total prescribing of different drug groups 1988-1997 is presented, as well as changes in patterns. DESIGN: A descriptive prescription study performed 3 months each year in 10 consecutive years. SETTING: Medical service and pharmacies in Halland. SUBJECTS: Prescriptions from about 100 GPs of PPCCs and 550 physicians of various other specialties. MAIN OUTCOME MEASURES: Percentages and absolute numbers of GPs prescribing. RESULTS: GPs prescribed 45% and 51% of the prescriptions from physicians in 1988 and 1997, respectively, while the cost shares were 40% and 42%. An increase in prescriptions was seen both in relative and in absolute numbers (from 117414 in 3 months in 1988 to 161012 in 1995). The increase in cost per DDD (defined daily dose) during the study period was 47% for GPs and 72% for other doctors. CONCLUSIONS: GP prescribing increased in both absolute and relative numbers, while the cost increase per DDD was moderate compared to other physicians.

  • 58.
    Silwer, Louise
    et al.
    Nordic School of Public Health, Göteborg, Sweden.
    Lundborg, Cecilia Stålsby
    Department of Public Health Sciences, IHCAR, Karolinska Institutet Stockholm, Sweden.
    Patterns of drug use during a 15 year period: data from a Swedish county, 1988--20022005In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 14, no 11, p. 813-20Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To present and interpret drug prescription patterns, related to various groups of the population in a Swedish county, in order to estimate the prevalence of drug use in different age groups. METHODS: Data on prescriptions, dispensed March-May 1988-2002, were combined with population statistics of Halland, a county in the south of Sweden, and analysed. Number of defined daily doses (DDD) per 100 inhabitants and day and prescriptions per 100 inhabitants and 3 months were used as indicators of drug prevalence. RESULTS: The total drug exposure in the population of Halland nearly doubled during the 15-year period. The most frequently used drugs overall, in 2002, were psycholeptics (N05), analgesics (N02), antibacterials (J01) and sex hormones (G03). Nearly 30% of the women of 15-69 years were exposed to sex hormones. Multiplied drug prevalence among people above 60 was found for antithrombotic drugs (B01), agents acting on the renin-angiotensin system (C09), sex hormones (G03), serum lipid reducing agents (C10), antidepressants (N06) and drugs for peptic ulcer and GORD (A02B). CONCLUSIONS: The increase in drug prescribing over the 15 years concerned both symptom-related treatments, like hormone replacement therapy, analgesics, antidepressants and drugs for acid-related disorders, as well as preventive treatments, like antithrombotics, lipid-lowering drugs and antihypertensives. The unit DDD/100 inhabitants and day gives a fairly correct measure of the percentage treated for chronic disorders. However, for short-term treatment courses and especially for drug use in children, number of prescriptions/100 inhabitants and adequate period of time, is easier to interpret.

  • 59.
    Silwer, Louise
    et al.
    Halmstad University, School of Social and Health Sciences (HOS), Centre of Research on Welfare, Health and Sport (CVHI).
    Lundborg, Cecilia Stålsby
    Nordiska Högskolan för folkhälsovetenskap, Göteborg, Sverige.
    Petzold, Max
    Nordiska Högskolan för folkhälsovetenskap, Göteborg, Sverige.
    Prevalence of purchase of antihypertensive and serum lipid-reducing drugs in Sweden: individual data from national registers2008In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 17, no 1, p. 37-42Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To determine the prevalence of purchase of prescribed antihypertensive and/or serum lipid-reducing pharmaceutical preparations among different age groups, from the age of 45, in the Swedish population. Further, to calculate the percentage of the population, from the age of 60, who purchased these pharmaceuticals without having had a circulatory diagnosis in the Hospital Discharge Register the last 7 years, or having purchased nitrate vasodilators, as an attempt to estimate the proportion of primary preventive treatments. METHODS: A cross-sectional study, of individual data on prescriptions for antihypertensives (C02-C03, C07-C09) and serum lipid-reducing agents (C10), dispensed from July to December 2005 for the Swedish population. Data were obtained from the new Swedish Prescribed Drugs Register. The data were related to population statistics, and linked to data on diagnoses of cardiovascular disease (I00-I99), from the Swedish Hospital Discharge Register 1998-2004. Data on individuals with purchase of antihypertensive or serum lipid-reducing agents, but without a diagnosis of cardiovascular disease, were also linked to purchase of nitrate vasodilators (C01D). RESULTS: Among Swedes of 60 years and above, 53% purchased antihypertensive or serum lipid-reducing pharmaceuticals, and 30% purchased the pharmaceuticals without having been hospitalized for a coronary or cerebrovascular event during the previous 7 years, or having purchased prescribed nitrate vasodilators during 6 months. CONCLUSION: Over half of the Swedish senior population purchased prescribed antihypertensive or serum lipid-reducing drugs during 6 months in 2005. The magnitude of the prevalence points to the importance of intensified follow-up of both adverse effects and of effectiveness of these drugs.

  • 60.
    Silwer, Louise
    et al.
    Nordic School of Public Health, Gothenburg, Sweden.
    Petzold, Max
    Nordic School of Public Health, Gothenburg, Sweden.
    Hallas, Jesper
    Department of Clinical Pharmacology, Syddansk Universitet, Odense, Denmark.
    Stålsby-Lundborg, Cecilia
    Department of Public Health Sciences, Division of International Health (IHCAR), Karolinska Institutet, Stockholm, Sweden.
    Statins and nonsteroidal anti-inflammatory drugs: an analysis of prescription symmetry2006In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 15, no 7, p. 510-511Article in journal (Refereed)
  • 61.
    Silwer, Louise
    et al.
    Halmstad University, School of Social and Health Sciences (HOS), Centre of Research on Welfare, Health and Sport (CVHI).
    Stålsby Lundborg, Cecilia
    Nordiska Högskolan för folkhälsovetenskap, Göteborg.
    Drug prescribing in primary care related to patient age: trends in a ten-year repeated prescription study in a Swedish province2005In: European Journal of General Practice, ISSN 1381-4788, E-ISSN 1751-1402, Vol. 11, no 1, p. 23-24, 28Article in journal (Refereed)
  • 62.
    Stelzer, J E
    et al.
    Department of Physiology, Univ. of Wisconsin Medical School, Madison, WI 53706, United States.
    Patel, J R
    Department of Physiology, Univ. of Wisconsin Medical School, Madison, WI 53706, United States.
    Olsson, M Charlotte
    Department of Physiology, Univ. of Wisconsin Medical School, Madison, WI 53706, United States.
    Fitzsimons, D P
    Department of Physiology, Univ. of Wisconsin Medical School, Madison, WI 53706, United States.
    Leinwand, L A
    Dept. Molec., Cell., Devmtl. Biol., University of Colorado, Boulder, CO 80309, United States.
    Moss, R L
    Department of Physiology, Univ. of Wisconsin Medical School, Madison, WI 53706, United States.
    Expression of cardiac troponin T with COOH-terminal truncation accelerates cross-bridge interaction kinetics in mouse myocardium2004In: American Journal of Physiology. Heart and Circulatory Physiology, ISSN 0363-6135, E-ISSN 1522-1539, Vol. 287, no 4, p. H1756-H1761Article in journal (Refereed)
  • 63.
    Sundström, Tomas
    et al.
    Halmstad University, School of Business, Engineering and Science.
    Ronkainen, Fanny
    Halmstad University, School of Business, Engineering and Science.
    Brorsson, Sofia
    Halmstad University, School of Business, Engineering and Science, Biological and Environmental Systems (BLESS).
    Olsson, M. Charlotte
    Halmstad University, School of Business, Engineering and Science, Biological and Environmental Systems (BLESS), Biomechanics and Biomedicine.
    Five Weeks of Plyometric Training Improve Vertical Jump Height in Female Handball Players During In-Season2010In: Nordic Conference 2010: Abstracts / [ed] Karen Søgaard, Karsten Froberg & Mette Krogh Christensen, Odense: University of Southern Denmark , 2010, p. 112-113Conference paper (Refereed)
    Abstract [en]

    Introduction: Handball is a sport requiring many different physical qualities in order to perform well, one of which is good jumping ability. For handball players available time to enhance power during in-season is often restricted due to an already high training load emphasizing other aspects of the sport than jumping ability. Therefore, one aim of this study was to examine if a small amount of additional plyometric training during in-season, combining drop jumps and box jumps, could give significant improvements in vertical jump height in female handball players after five weeks of training. Generally, vertical jump height is evaluated with two-legged tests, however, the question arises if the tests are relevant in sports that predominantly use several steps and one-leg jumps such as handball. A second aim of this study was thus to develop, evaluate and validate a handball-specific test performed on one leg.

    Methods: Two Swedish female handball-teams playing in the third division were recruited. Players from one team made up the intervention-group (n = 9) and players from the other team functioned as the control-group (n = 4). Plyometric training was added to the regular handball training session twice per week during five weeks, lasting approximately 15 minutes per session, consisting of two sets of eight repetitions of drop jumps and box jumps respectively, while the control-group continued their training as normal. Jumping performance was evaluated through the squat jump test (SJ), countermovement jump test (CMJ) and the handball-specific one leg jump test (OLJ) developed for this study in order to offer a more sport-specific evaluation tool when testing sports that predominantely jump on one leg.

    Results: The intervention-group improved their jumping height significantly with 2,7 cm in the SJ, 3,6cm in the CMJ and 3,6 cm in the OLJ (p < 0,01 for all). The control-group had an opposite trend with diminishing results in all three jumps, -1,5 cm in the SJ (p < 0,05), -1,7 cm in the CMJ (p < 0,05) and -0,9 cm in the OLJ (not significant). The one-legged jump test (OLJ) correlated well with both SJ (r= 0,79, p <0,01 ), and CMJ (r=0,75, p < 0,01).

    Discussion: The present study found significant improvements in jumping height after only five weeks of plyometric training for female handball players. Interestingly, the intervention-group improved to the same extent in both the one and the two-leg jumps test, which might be explained by the accumulation of handball specific training drills performed on one-leg, together with the two-legged plyometric exercises. The same assumption could also explain why the control-group showed no change in the one-leg jump test between the pre and post-tests, but displayed significant lower scores in the two-legged jumping tests after 5 weeks with only regular handball training.

    Conclusion: The improvements seen in this study with a small amount of additional plyometric training is relevant for coaches that need to provide gains in jumping performance during in-season when there is not a lot of time for additional training. Moreover, an evaluation test needs to be as specific as possible to the performance in the sport. The one-leg vertical jump test, developed in this study, could be a first step to a future handball-test that better resembles the jumping performance in handball than already established two-leg jumping tests.

  • 64.
    Sällström, Benjamin
    et al.
    Halmstad University. Halmstad University, School of Business and Engineering (SET).
    Kareliussén, Tobias
    Halmstad University. Halmstad University, School of Business and Engineering (SET).
    Hur påverkas muskelaktiviteten vid styrketräning med en tjock stång i jämförelse med en standardolympisk stång?: En EMG- studie2010Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Many everyday tasks and also many sports require good grip and forearm strength. Everything from carrying boxes and lifting a child to grab the arms and legs in various martial arts, or holding a tennis racket involving the hand and forearm muscles in various ways. It is therefore important to train these muscles to prevent injuries and congestion and to perform well in sport. A well known way to train functional strength in the hand and forearm muscles is weight training with thick handles. The purpose of this study was to investigate the differences in muscle activity in the upper arm and forearm muscles as well as the deltoids between two bars of different diameter (28mm and 57mm) in two different weight training exercises using electromyography (EMG). The weight training exercises consisted of a pulling exercise in the form of a bench row and a pressing exercise in the form of close-grip bench press. The study also examines whether there is a connection between hand strength and muscle activity, and if there is any connection between hand size and muscle activity. Results show that muscle activity between the thick bars remained unchanged in the close-grip bench press. In the bench row exercise, however, significant increases were seen in the forearm flexors and m. biceps brachii while lifting the thicker bar. The forearm extensors showed an indication of muscle activity increases while lifting the thicker bar. However, there was no connection between hand strength and muscle activity and no correlation between hand size and muscle activity. The conclusion is that the pulling exercise with the thicker bar results in higher muscle activity in comparison to a standard Olympic bar in several muscles involved, not just those directly affected by the thicker bar.

  • 65.
    Teneberg, Susanne
    et al.
    Halmstad University, School of Information Technology. Institute of Medical Biochemistry, Göteborg University, P. O. Box 440, SE 405 30 Göteborg, Sweden.
    Leonardsson, I.
    Department of Clinical Microbiology and Immunology, Örebro Medical Centre Hospital, SE 701 85 Örebro, Sweden.
    Karlsson, H.
    Department of General Surgery, Örebro Medical Centre Hospital, SE 701 85 Örebro, Sweden.
    Jovall, P.-A.
    Department of Medical Microbiology, Dermatology, and Infection, University of Lund, SE 223 62 Lund, Sweden.
    Ångström, J.
    Institute of Medical Biochemistry, Göteborg University, P. O. Box 440, SE 405 30 Göteborg, Sweden.
    Danielsson, D.
    Institute of Medical Biochemistry, Göteborg University, P. O. Box 440, SE 405 30 Göteborg, Sweden.
    Näslund, I.
    Institute of Medical Biochemistry, Göteborg University, P. O. Box 440, SE 405 30 Göteborg, Sweden.
    Ljungh, A.
    Institute of Medical Biochemistry, Göteborg University, P. O. Box 440, SE 405 30 Göteborg, Sweden.
    Wadström, T.
    Institute of Medical Biochemistry, Göteborg University, P. O. Box 440, SE 405 30 Göteborg, Sweden.
    Karlsson, K.-A
    Institute of Medical Biochemistry, Göteborg University, P. O. Box 440, SE 405 30 Göteborg, Sweden.
    Lactotetraosylceramide, a novel glycosphingolipid receptor for Helicobacter pylori, present in human gastric epithelium2002In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 277, no 22, p. 19709-19719Article in journal (Refereed)
    Abstract [en]

    The binding of Helicobacterpylori to glycosphingolipids was examined by binding of 35S-labeled bacteria to glycosphingolipids on thin-layer chromatograms. In addition to previously reported binding specificities, a selective binding to a non-acid tetraglycosylceramide of human meconium was found. This H. pylori binding glycosphingolipid was isolated and, on the basis of mass spectrometry, proton NMR spectroscopy, and degradation studies, were identified as Galβ3GlcNAcβ3-Galβ4Glcβ1Cer (lactotetraosylceramide). When using non-acid glycosphingolipid preparations from human gastric epithelial cells, an identical binding of H. pylori to the tetraglycosylceramide interval was obtained in one of seven samples. Evidence for the presence of lactotetraosylceramide in the binding-active interval was obtained by proton NMR spectroscopy of intact glycosphingolipids and by gas chromatography-electron ionization mass spectrometry of permethylated tetrasaccharides obtained by ceramide glycanase hydrolysis. The lactotetraosylceramide binding property was detected in 65 of 74 H. pylori isolates (88%) Binding of H. pylori to lactotetraosylceramide on thin-layer chromatograms was inhibited by preincubation with lactotetraose but not with lactose. Removal of the terminal galactose of lactotetraosylceramide by galactosidase hydrolysis abolished the binding as did hydrazinolysis of the acetamido group of the N-acetylglucosamine. Therefore, Galβ3GlcNAc is an essential part of the binding epitope.

  • 66.
    Thorén, Lina A.
    et al.
    Lunds Universitet, Lund, Sverige.
    Liuba, Karina
    Lunds Universitet, Lund, Sverige.
    Bryder, David
    Lunds Universitet, Lund, Sverige.
    Nygren, Jens Martin
    Lunds universitet, Lund, Sverige.
    Jensen, Christina T
    Lunds Universitet, Lund, Sverige.
    Qian, Hong
    Lunds Universitet, Lund, Sverige.
    Antonchuk, Jennifer
    Lunds Universitet, Lund, Sverige.
    Jacobsen, Sten-Eirik W
    Lunds Universitet, Lund, Sverige.
    Kit regulates maintenance of quiescent hematopoietic stem cells2008In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 180, no 4, p. 2045-2053Article in journal (Refereed)
    Abstract [en]

    Hematopoietic stem cell (HSC) numbers are tightly regulated and maintained in postnatal hematopoiesis. Extensive studies have supported a role of the cytokine tyrosine kinase receptor Kit in sustaining cycling HSCs when competing with wild-type HSCs posttransplantation, but not in maintenance of quiescent HSCs in steady state adult bone marrow. In this study, we investigated HSC regulation in White Spotting 41 (Kit(W41/W41)) mice, with a partial loss of function of Kit. Although the extensive fetal HSC expansion was Kit-independent, adult Kit(W41/W41) mice had an almost 2-fold reduction in long-term HSCs, reflecting a loss of roughly 10,000 Lin(-)Sca-1(+)Kit(high) (LSK)CD34(-)Flt3(-) long-term HSCs by 12 wk of age, whereas LSKCD34(+)Flt3(-) short-term HSCs and LSKCD34(+)Flt3(+) multipotent progenitors were less affected. Whereas homing and initial reconstitution of Kit(W41/W41) bone marrow cells in myeloablated recipients were close to normal, self-renewing Kit(W41/W41) HSCs were progressively depleted in not only competitive but also noncompetitive transplantation assays. Overexpression of the anti-apoptotic regulator BCL-2 partially rescued the posttransplantation Kit(W41/W41) HSC deficiency, suggesting that Kit might at least in the posttransplantation setting in part sustain HSC numbers by promoting HSC survival. Most notably, accelerated in vivo BrdU incorporation and cell cycle kinetics implicated a previously unrecognized role of Kit in maintaining quiescent HSCs in steady state adult hematopoiesis.

  • 67.
    Urrutia-Cordero, Pablo
    et al.
    Halmstad University, School of Business, Engineering and Science. Univ Autonoma Madrid, Dept Biol, Madrid 28049, Spain..
    Agha, Ramsy
    Univ Autonoma Madrid, Dept Biol, Madrid 28049, Spain..
    Cires, Samuel
    Univ Autonoma Madrid, Dept Biol, Madrid 28049, Spain..
    Angeles Lezcano, Maria
    Univ Autonoma Madrid, Dept Biol, Madrid 28049, Spain..
    Sanchez-Contreras, Maria
    Univ Autonoma Madrid, Dept Biol, Madrid 28049, Spain..
    Waara, Karl-Otto
    Halmstad University, School of Business, Engineering and Science, The Rydberg Laboratory for Applied Sciences (RLAS).
    Utkilen, Hans
    Norwegian Inst Publ Hlth, Dept Water Hyg, N-0403 Oslo, Norway..
    Quesada, Antonio
    Univ Autonoma Madrid, Dept Biol, Madrid 28049, Spain..
    Effects of harmful cyanobacteria on the freshwater pathogenic free-living amoeba Acanthamoeba castellanii2013In: Aquatic Toxicology, ISSN 0166-445X, E-ISSN 1879-1514, Vol. 130, p. 9-17Article in journal (Refereed)
    Abstract [en]

    Grazing is a major regulating factor in cyanobacterial population dynamics and, subsequently, considerable effort has been spent on investigating the effects of cyanotoxins on major metazoan grazers. However, protozoan grazers such as free-living amoebae can also feed efficiently on cyanobacteria, while simultaneously posing a major threat for public health as parasites of humans and potential reservoirs of opportunistic pathogens. In this study, we conducted several experiments in which the freshwater amoeba Acanthamoeba castellanii was exposed to pure microcystin-LR (MC-LR) and six cyanobacterial strains, three MC-producing strains (MC-LR, MC-RR, MC-YR, MC-WR, [Dha7] MC-RR) and three strains containing other oligopeptides such as anabaenopeptins and cyanopeptolins. Although the exposure to high concentrations of pure MC-LR yielded no effects on amoeba, all MC-producing strains inflicted high mortality rates on amoeba populations, suggesting that toxic effects must be mediated through the ingestion of toxic cells. Interestingly, an anabaenopeptin-producing strain caused the greatest inhibition of amoeba growth, indicating that toxic bioactive compounds other than MCs are of great importance for amoebae grazers. Confocal scanning microscopy revealed different alterations in amoeba cytoskeleton integrity and as such, the observed declines in amoeba densities could have indeed been caused via a cascade of cellular events primarily triggered by oligopeptides with protein-phosphatase inhibition capabilities such as MCs or anabaenopeptins. Moreover, inducible-defense mechanisms such as the egestion of toxic, MC-producing cyanobacterial cells and the increase of resting stages (encystation) in amoebae co-cultivated with all cyanobacterial strains were observed in our experiments. Consequently, cyanobacterial strains showed different susceptibilities to amoeba grazing which were possibly influenced by the potentiality of their toxic secondary metabolites. Hence, this study shows the importance of cyanobacterial toxicity against amoeba grazing and, that cyanobacteria may contain a wide range of chemical compounds capable of negatively affect free-living, herbivorous amoebae. Moreover, this is of high importance for understanding the interactions and population dynamics of such organisms in aquatic ecosystems. (c) 2012 Elsevier B.V. All rights reserved.

  • 68.
    Westerberg, Martin
    Halmstad University, School of Business and Engineering (SET).
    MUSKULÄR STYRKA VID MULTIPLA REPETITIONER:: SKILLNADER VID STYRKETEST I BÄNKPRESS OCH LIGGANDE BÄNKRODD MED SKIVSTÄNGER AV OLIKA DIAMETEROMFÅNG2010Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Introduction: A complex interaction between muscles, tendons, bones, joints and nerves are required for optimal function of the human hand. It is known that an individual’s grip strength is vital for performance of physical demanding tasks such as strength training with free weights. Strength training including a thicker grip around the bar may enhance the strength of the grip in the athlete without other special routines for grip strength development. The purpose of this investigation was to examine the difference in performance in multiple repetitions in two strength training exercises using two different sizes on the bar, to look for correlations between grip strength of the subjects hand and the amount of repetitions executed with two different size of the bar and finally the correlation of hand size and the amount of repetitions executed with two different size of the bar.

    Method: 15 strength training men (23,9 ± 4,1 years), underwent measurements of hand size, maximum grip strength, 1 repetition maximum (1RM), a 80 % of 1RM weight strength test with two different  bar sizes.

    Results: The results from the present investigation indicates a 21,1 % reduction of 80 % of 1 RM weight performance in repetitions executed in the bench press with the thicker diameter of the bar and a 66,2 % reduction in repetitions executed with a 80 % of 1 RM weight in the lying bench row with the thicker diameter of the bar. The size of the hand or the maximum grip strength does not influences the performance in the 80 % of 1 RM strength test.

    Conclusion: With support of the results from this present investigation the size of the bar diameter significant influences the performance in maximum repetitions executed in a set in strength training with free weights, in a rowing exercise the repetitions executed reduced with 66,2 % and in the bench press the reduction of executed repetitions were 21,1 % with the thicker diameter of the bar. The size of the hand do not influences the performance of maximal executed repetitions with the thicker bar diameter. Maximal grip strength has no influence of the performance according to the findings of this investigation.

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