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  • 1.
    Larsson, Ingrid
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Aili, Katarina
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Lönn, Maria
    Högskolan i Halmstad, Akademin för hälsa och välfärd. Psychiatry Halland, Halmstad, Sweden.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Ivarsson, Andreas
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Johansson, Pia
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Sleep interventions for children with attention deficit hyperactivity disorder (ADHD): A systematic literature review2023Inngår i: Sleep Medicine, ISSN 1389-9457, E-ISSN 1878-5506, Vol. 102, s. 64-75Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Objective/background: Healthy sleep is particularly important for children with attention deficit hyperactivity disorder (ADHD), as sleep disturbances might aggravate disease symptoms. This review aims to synthesize and report evidence on the effectiveness of sleep interventions in increasing sleep, quality of life (QoL), and ADHD symptoms among children with ADHD. Patients/methods: The systematic literature review follows the Cochrane Collaboration methodology recommendations for literature reviews. Four databases were used based on the population, intervention, control and outcome (PICO) framework. Controlled trials with minimum 20 children in each group, aged 6–18, and published from 2005 and onwards were included. Results from the studies were reported in forest plots and three of the seven review outcomes were synthesized in meta-analyses. Results: The search identified 7710 records; of which 4808 abstracts were screened. After fulltext-screening of 99 papers, eight papers from five studies were included. The studies included behavioral sleep interventions and pharmacological interventions using melatonin and eszopiclone. For six of the seven outcomes, the effect sizes were small to moderate and the certainty of the evidence was low. For one outcome, sleep disturbances, the effect size was a moderate −0.49 standardized mean differences (95% confidence interval −0.65;-0.33), with a moderate certainty of evidence for the behavioral interventions for children aged 5–13 years with ADHD. Conclusions: This review identified few and heterogeneous studies. A moderate certainty of evidence for a moderate effect size was only obtained for sleep disturbances from the behavioral interventions. A low certainty of the evidence for a moderate effect size was found for the total sleep time from the pharmacological intervention using melatonin and one behavioral intervention, which indicates that these sleep interventions impact sleep quantity and quality among children with ADHD. © 2022 The Authors

  • 2.
    Larsson, Ingrid
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd. Spenshult Research and Development Centre, Halmstad, Sweden; Department of Clinical Sciences, Lund University, Lund, Sweden.
    Aili, Katarina
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Johansson, Pia
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Jarbin, Håkan
    Faculty of Medicine, Lund University, Lund, Sweden; Child and Adolescent Psychiatry, Region Halland, Halmstad, Sweden.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    SLEEP: intervention with weighted blankets for children with attention deficit hyperactivity disorder (ADHD) and sleep problems2022Inngår i: BMJ Open, E-ISSN 2044-6055, Vol. 12, nr 1, artikkel-id e047509Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    INTRODUCTION AND OBJECTIVES: Children with attention deficit hyperactivity disorder (ADHD) have an increased risk of sleep problems. Weighted blankets are one possible non-pharmacological intervention for these problems in this group of children. However, the effectiveness of weighted blankets is insufficiently investigated. This study aims to investigate the effectiveness of weighted blankets in terms of sleep, health-related outcomes and cost-effectiveness as well as to explore children's and parents' experiences of a sleep intervention with weighted blankets.

    METHODS AND ANALYSIS: This study is a randomised placebo-controlled crossover trial comparing the effect of weighted fibre blankets (active) with fibre blankets without weight (control). Children aged 6-13 years, recently diagnosed with uncomplicated ADHD with verified sleep problems, were included in the study. The study period is 4 weeks for each condition, respectively, and then an 8-week follow-up. A total of 100 children diagnosed with ADHD and sleep problems will enter the study. The primary outcomes are sleep and cost per quality-adjusted life years. The secondary outcomes are health-related quality of life, ADHD symptoms, psychological distress and anxiety. Interviews with a subsample of the participating children and parents will be conducted for exploring the experiences of the intervention.

    ETHICS AND DISSEMINATION: Ethical approval of the trial has been obtained from the Swedish Ethical Review Authority (number 2019--2158) and conforms to the principles outlined in the Declaration of Helsinki (WMA, 2013). Results will be reported as presentations at peer-review conferences, in articles in peer-review journals and meetings with healthcare providers.

    TRIAL REGISTRATION NUMBER: NCT04180189. © Author(s) (or their employer(s)) 2022.

  • 3.
    Lindgren, Eva-Carin
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Källstrand Eriksson, Jeanette
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Alftberg, Åsa
    Malmö University, Malmö, Sweden.
    Johansson, Pia
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Kristén, Lars
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Håman, Linn
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Ivarsson, Andreas
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Carlsson, Ing-Marie
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Empowerment-Based Physical Activity Intervention for People with Advanced Dry Age-Related Macular Degeneration: Mixed-Methods Protocol2023Inngår i: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 20, nr 1, artikkel-id 643Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Age-related macular degeneration (AMD) is the most common cause of incurable visual impairment and impacts daily life. These impacts include loss of social activities, decreased functional independence, and reduced physical activity. This protocol aims to describe a prospective, mixed-methodology for studying a population with AMD before, during, and after an empowerment-based physical activity intervention (EPI). A study framework was also developed for EPI. The intervention will include 20 older individuals (age 65+ years) with AMD recruited in Sweden. The intervention period is six months and comprises adapted physical activity and social activities in a group twice a week and individual health coaching on three occasions. The quantitative pre-test and three follow-ups include physical functional tests, an accelerometer that monitors physical activity continuously for one week, and questionnaires. Individual and focus-group interviews and ethnographic observations will explore the experience of living with AMD and what it means to participate in the EPI for individuals with AMD. The chosen methodology offers a structured way for researchers to explore the experiences and factors that may provide insights into the potential of creative supervised, adapted physical activity in groups, health coaching, and socialising that are significant to enable well-being among older individuals with AMD. © 2022 by the authors.

  • 4.
    Mekuria, Selamawit F.
    et al.
    Lund University, Lund, Sweden.
    Timmermans, Sydney
    University Of Guelph, Guelph, Canada; Mcgill University, Montreal, Canada.
    Borgfeldt, Christer
    Lund University, Lund, Sweden.
    Jerkeman, Mats
    Lund University, Lund, Sweden.
    Johansson, Pia
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Linde, Ditte Søndergaard
    University Of Southern Denmark, Odense, Denmark; Odense University Hospital, Odense, Denmark.
    HPV self-sampling versus healthcare provider collection on the effect of cervical cancer screening uptake and costs in LMIC: a systematic review and meta-analysis2023Inngår i: Systematic Reviews, E-ISSN 2046-4053, Vol. 12, nr 1, artikkel-id 103Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Background: Cervical cancer is a major global health issue, with 89% of cases occurring in low- and middle-income countries (LMICs). Human papillomavirus (HPV) self-sampling tests have been suggested as an innovative way to improve cervical cancer screening uptake and reduce the burden of disease. The objective of this review was to examine the effect of HPV self-sampling on screening uptake compared to any healthcare provider sampling in LMICs. The secondary objective was to estimate the associated costs of the various screening methods. Method: Studies were retrieved from PubMed, Embase, CINAHL, CENTRAL (by Cochrane), Web of Science, and ClinicalTrials.gov up until April 14, 2022, and a total of six trials were included in the review. Meta-analyses were performed mainly using the inverse variance method, by pooling effect estimates of the proportion of women who accepted the screening method offered. Subgroup analyses were done comparing low- and middle-income countries, as well as low- and high-risk bias studies. Heterogeneity of the data was assessed using I 2. Cost data was collected for analysis from articles and correspondence with authors. Results: We found a small but significant difference in screening uptake in our primary analysis: RR 1.11 (95% CI: 1.10–1.11; I 2 = 97%; 6 trials; 29,018 participants). Our sensitivity analysis, which excluded one trial that measured screening uptake differently than the other trials, resulted in a clearer effect in screening uptake: RR: 1.82 (95% CI: 1.67–1.99; I 2 = 42%; 5 trials; 9590 participants). Two trials reported costs; thus, it was not possible to make a direct comparison of costs. One found self-sampling more cost-effective than the provider-required visual inspection with acetic acid method, despite the test and running costs being higher for HPV self-sampling. Conclusion: Our review indicates that self-sampling improves screening uptake, particularly in low-income countries; however, to this date, there remain few trials and associated cost data. We recommend further studies with proper cost data be conducted to guide the incorporation of HPV self-sampling into national cervical cancer screening guidelines in low- and middle-income countries. Systematic review registration: PROSPERO CRD42020218504. © 2023, The Author(s).

  • 5.
    Neyt, Mattias
    et al.
    KCE, Belgium.
    García-Pérez, Lidia
    SESCS-FUNCANIS, Spain.
    Johansson, Pia
    SBU, Swedish Agency for Health Technology Assessment and Assessment of Social Services, Stockholm, Sweden.
    Midy, Fabienne
    HAS, France.
    Teljeur, Conor
    HIQA, Ireland.
    Practical considerations when critically assessing economic evaluations. Guidance document.2020Rapport (Annet vitenskapelig)
    Fulltekst (pdf)
    fulltext
  • 6.
    Rystedt, J.M.L.
    et al.
    Lunds University, Lund, Sweden.
    Wiss, J.
    Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden.
    Adolfsson, J.
    Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden.
    Enochsson, L.
    Karolinska Institutet, Stockholm, Sweden; Umeå University, Umea, Sweden.
    Hallerbäck, B.
    Northern Alvsborg Hospital, Trollhattan, Sweden.
    Johansson, Pia
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Jönsson, C.
    Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Sahlgrenska University Hospital, Gothenburg, Sweden.
    Leander, P.
    Skane University Hospital, Malmo, Sweden.
    Österberg, J.
    Mora Hospital, Mora, Sweden.
    Montgomery, A.
    Lunds University, Lund, Sweden.
    Routine versus selective intraoperative cholangiography during cholecystectomy: systematic review, meta-analysis and health economic model analysis of iatrogenic bile duct injury2021Inngår i: BJS Open, E-ISSN 2474-9842, Vol. 5, nr 2, artikkel-id zraa032Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Bile duct injury (BDI) is a severe complication following cholecystectomy. Early recognition and treatment of BDI has been shown to reduce costs and improve patients' quality of life. The aim of this study was to assess the effect and cost-effectiveness of routine versus selective intraoperative cholangiography (IOC) in cholecystectomy. METHODS: A systematic review and meta-analysis, combined with a health economic model analysis in the Swedish setting, was performed. Costs per quality-adjusted life-year (QALY) for routine versus selective IOC during cholecystectomy for different scenarios were calculated. RESULTS: In this meta-analysis, eight studies with more than 2 million patients subjected to cholecystectomy and 9000 BDIs were included. The rate of BDI was estimated to 0.36 per cent when IOC was performed routinely, compared with to 0.53 per cent when used selectively, indicating an increased risk for BDI of 43 per cent when IOC was used selectively (odds ratio 1.43, 95 per cent c.i. 1.22 to 1.67). The model analysis estimated that seven injuries were avoided annually by routine IOC in Sweden, a population of 10 million. Over a 10-year period, 33 QALYs would be gained at an approximate net cost of €808 000 , at a cost per QALY of about €24 900. CONCLUSION: Routine IOC during cholecystectomy reduces the risk of BDI compared with the selective strategy and is a potentially cost-effective intervention. © The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd.

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