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  • 1.
    Ahlborg, Mikael
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Nyholm, Maria
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Morgan, Antony
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI). Glasgow Caledonian University in London, London, United Kingdom.
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Into the realm of social capital for adolescents: A latent profile analysis2019Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, nr 2, artikkel-id e0212564Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    Recent reports of increasing prevalence of frequent health complaints and mental health problems among adolescents call for directing more attention on determinants of adolescent health. The relationship between health and social capital has gained increased attention since the early 2000’s and research at review level confirms the importance of social capital for health outcomes, despite methodological heterogeneity. The aim of this study was to identify distinct profiles of family, school and peer social capital in a nationally representative sample of adolescents and to explore health outcomes in those profiles.

    Method

    Cross-sectional data from the Swedish Health Behaviour of School-aged Children 2013/14 was used for this study. The analytical sample consisted of 7,804 adolescents aged 11-, 13- and 15-years. Items representing sense of belonging and emotional support were assessed in three contexts; family, school and among peers. Latent profile analyses (LPA) were run to determine social capital profiles. Health outcomes included frequent health complaints and life satisfaction, while socioeconomic status and genders were included as predictors.

    Results

    The results show that five distinct profiles best represent the data for 11- and 15-year olds, while a four-profile model was optimal for 13-year olds. Some profiles were recurrent between age groups but unique profiles were also found. Health outcomes were significantly different between profiles depending on levels of social capital in the different contexts.

    Conclusions

    This study provides novel insight into how social capital co-occurs among adolescents within the contexts of family, school and peers and how this translates into differences in health outcomes. The national representativeness of the sample increases the implications of the results and contributes to meaningful insights that help explain the interactions of social capital in multiple contexts, complementing what is previously known about the relationship with adolescent health. © 2019 Ahlborg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • 2.
    Ahlborg, Mikael
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Nyholm, Maria
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Morgan, Antony
    Glasgow Caledonian University, Glasgow, United Kingdom.
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Socioeconomic inequalities in health among Swedish adolescents - adding the subjective perspective2017Inngår i: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 17, artikkel-id 838Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    Socioeconomic inequalities in adolescent health predict future inequalities in adult health. Subjective measures of socioeconomic status (SES) may contribute with an increased understanding of these inequalities. The aim of this study was to investigate socioeconomic health inequalities using both a subjective and an objective measure of SES among Swedish adolescents.

    Method

    Cross-sectional HBSC-data from 2002 to 2014 was used with a total sample of 23,088 adolescents aged 11–15 years. Three measures of self-rated health (dependent variables) were assessed: multiple health complaints, life satisfaction and health perception. SES was measured objectively by the Family Affluence Scale (FAS) and subjectively by “perceived family wealth” (independent variables). The trend for health inequalities was investigated descriptively with independent t-tests and the relationship between independent and dependent variables was investigated with multiple logistic regression analysis. Gender, age and survey year was considered as possible confounders.

    Results

    Subjective SES was more strongly related to health outcomes than the objective measure (FAS). Also, the relation between FAS and health was weakened and even reversed (for multiple health complaints) when subjective SES was tested simultaneously in regression models (FAS OR: 1.03, CI: 1.00;1.06 and subjective SES OR: 0.66, CI: 0.63;0.68).

    Conclusions

    The level of socioeconomic inequalities in adolescent health varied depending on which measure that was used to define SES. When focusing on adolescents, the subjective appraisals of SES is important to consider because they seem to provide a stronger tool for identifying inequalities in health for this group. This finding is important for policy makers to consider given the persistence of health inequalities in Sweden and other high-income countries. ©  The Author(s). 2017

  • 3.
    Arnarsson, Arsaell
    et al.
    University of Iceland, Reykjavik, Iceland.
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Nyholm, Maria
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Torsheim, Torbjorn
    University of Bergen, Bergen, Norway.
    Augustine, Lilly
    University of Kristianstad, Kristianstad, Sweden.
    Bjereld, Ylva
    University of Gothenburg, Gothenburg, Sweden.
    Markkanen, Ilona
    University of Jyväskylä, Jyväskylä, Finland.
    Schnohr, Christina w.
    University of Copenhagen, Copenhagen, Denmark.
    Rasmussen, Mette
    University of Southern Denmark, Odense, Denmark.
    Nielsen, Line
    University of Southern Denmark, Odense, Denmark.
    Bendtsen, Pernille
    University of Southern Denmark, Odense, Denmark.
    Cyberbullying and traditional bullying among Nordic adolescents and their impact on life satisfaction2019Inngår i: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, s. 1-9Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aims: The aim of this study was to investigate the prevalence of cybervictimization in the six Nordic countries and to assess its overlap with traditional bullying. A further aim was to examine potential associations between life satisfaction, on the one hand, and traditional bullying and cyberbullying on the other. Methods: Analyses were based on data from the 2013⁄2014 Health Behaviour in School-aged Children study. It included 32,210 boys and girls, aged 11, 13, and 15, living in the six Nordic countries. Results: The prevalence of cyberbullying by both pictures and by messages was around 2% in all the Nordic countries except Greenland. There it was considerably higher. The prevalence of being bullied in a traditional manner varied widely by country. For boys, this type of bullying was most frequent in the youngest age group and then decreased steadily in the older age groups. Girls were on average more likely to be cyberbullied. Cyberbullying was more common among 13- and 15-year-olds than 11-year-olds. Higher family affluence was unrelated to the risk of cyberbullying. However, it was related to traditional bullying and combined forms of bullying. Compared with intact families, cybervictimization was commoner among single-parent families and stepfamilies. Adjusting for age, gender, family affluence, and family structure, those subjected to cyberbullying had lower life satisfaction than those who were not bullied. Conclusions: We found relatively little overlap between cyberbullying and traditional bullying, indicating that the two may be separate phenomena stemming from different mechanisms, at least in the Nordic context.

  • 4.
    Arvidsson, Susann
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Gilljam, Britt-Mari
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad. Region Halland, Halmstad, Sweden.
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Ruland, Cornelia Maria
    The Centre for Shared Decision Making and Collaborative Care Research (CSDM), Oslo University Hospital, Oslo, Norway & University of Oslo, Oslo, Norway.
    Nordby-Bøe, Trude
    The Centre for Shared Decision Making and Collaborative Care Research (CSDM), Oslo University Hospital, Oslo, Norway.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Redesign and Validation of Sisom, an Interactive Assessment and Communication Tool for Children With Cancer2016Inngår i: JMIR mhealth and uhealth, E-ISSN 2291-5222, Vol. 4, nr 2, artikkel-id e76Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Children with cancer undergo intensive and long treatment periods that expose them and their families to a number of difficult physical, mental, and social challenges. Empowering children by actively involving them in their care can help them to cope with these challenges. It can, however, be difficult for children to be involved and talk about their illness experiences in a "traditional" conversation with health care professionals, especially for younger children. Sisom (Norwegian acronym "Si det som det er" or "Tell it how it is") is an interactive computer-based assessment and communication tool to give children (aged 6-12 years) with cancer a "voice" in their care. Because of technological advances and widespread use of mobile devices Sisom had to be redesigned to better meet the needs of children of today.

    OBJECTIVE: To redesign Sisom for use on mobile devices and to validate and adapt it for use in a Swedish population of children with cancer.

    METHODS: A user-experience design was used. Content adaptation included forward-backward translation by Swedish and Norwegian translators. Healthy children (n=5), children with experiences of cancer treatment (n=5) and their parents (n=5), and pediatric nurses (n=2) were then involved in culturally adapting Sisom to the Swedish context. The iterative low- and high-fidelity evaluation was supported by a think aloud method, semistructured interviews, and drawings to capture children's views of Sisom. The redesign and evaluation continued until no further changes or improvements were identified by the participants or the researchers.

    RESULTS: Children, parents, and pediatric nurses offered many suggestions for improvements to the original version in terms of content, aesthetics, and usability of Sisom. The most significant change that emerged through user input was a modification that entailed not using problem-focused statements in the assessment items. The parents and pediatric nurses considered the revised assessment items to be general and less diagnosis specific. The evaluation of aesthetics resulted in brighter colors and more positive and exciting details in the animations. The evaluation of usability included improvements of the verbal instructions on how to navigate in Sisom 2, and also that the answers to assessmentitems in Sisom 2 should be saved to provide the children with the option to pause and to continue answering the remaining assessment items at a later stage.

    CONCLUSIONS: Overall, this paper describes the process of using user-experience design with children in order to redesign and validate an interactive assessment and communication tool and how the outcomes of this process resulted in a new version, Sisom 2. All participants confirmed the usability and qualities of using the final version. Future research should be directed toward the implementation of Sisom 2 in clinical practice and to evaluate outcomes from individual and organizational levels.

  • 5.
    Attema, Joanne L.
    et al.
    Immunology Unit, Institution for Experimental Medical Research, Lund University, Lund, Sweden.
    Pronk, Cornelis J. H.
    Immunology Unit, Institution for Experimental Medical Research, Lund University, Lund, Sweden.
    Norddahl, Gudmundur L.
    Immunology Unit, Institution for Experimental Medical Research, Lund University, Lund, Sweden.
    Nygren, Jens Martin
    Immunology Unit, Institution for Experimental Medical Research, Lund University, Lund, Sweden.
    Bryder, David
    Immunology Unit, Institution for Experimental Medical Research, Lund University, Lund, Sweden.
    Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence2009Inngår i: Oncogene, ISSN 0950-9232, E-ISSN 1476-5594, Vol. 28, nr 22, s. 2238-2243Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Somatic stem cells are ultimately responsible for mediating appropriate organ homeostasis and have therefore been proposed to represent a cellular origin of the ageing process-a state often characterized by inappropriate homeostasis. Specifically, it has been suggested that ageing stem cells might succumb to replicative senescence by a mechanism involving the cyclin-dependent kinase inhibitor p16(INK4A). Here, we tested multiple functional and molecular parameters indicative of p16(INK4A) activity in primary aged murine hematopoietic stem cells (HSCs). We found no evidence that replicative senescence accompanies stem cell ageing in vivo, and in line with p16(INK4A) being a critical determinant of such processes, most aged HSCs (>99%) failed to express p16(INK4A) at the mRNA level. Moreover, whereas loss of epigenetically guided repression of the INK4A/ARF locus accompanied replicative senescent murine embryonic fibroblasts, such repression was maintained in aged stem cells. Taken together, these studies indicate that increased senescence as mediated by the p16(INK4A) tumor suppressor has only a minor function as an intrinsic regulator of steady-state HSC ageing in vivo.

  • 6.
    Breitbach, Martin
    et al.
    University of Bonn, Bonn, Germany.
    Bostani, Toktam
    University of Bonn, Bonn, Germany.
    Roell, Wilhelm
    University of Bonn, Bonn, Germany.
    Xia, Ying
    University of Cologne, Cologne, Germany.
    Dewald, Oliver
    University of Bonn, Bonn, Germany.
    Nygren, Jens Martin
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Fries, Jochen W. U.
    University of Cologne, Cologne, Germany.
    Tiemann, Klaus
    University of Bonn, Bonn, Germany.
    Bohlen, Heribert
    Axiogenesis AG, Cologne, Germany.
    Hescheler, Juergen
    University of Cologne, Cologne, Germany.
    Welz, Armin
    University of Bonn, Bonn, Germany.
    Bloch, Wilhelm
    German Sport University, Cologne, Germany.
    Jacobsen, Sten Eirik W
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Fleischmann, Bernd K
    University of Bonn, Bonn, Germany.
    Potential risks of bone marrow cell transplantation into infarcted hearts2007Inngår i: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 110, nr 4, s. 1362-1369Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cellular replacement therapy has emerged as a novel strategy for the treatment of heart failure. The aim of our study was to determine the fate of injected mesenchymal stem cells (MSCs) and whole bone marrow (BM) cells in the infarcted heart. MSCs were purified from BM of transgenic mice and characterized using flow cytometry and in vitro differentiation assays. Myocardial infarctions were generated in mice and different cell populations including transgenic MSCs, unfractionated BM cells, or purified hematopoietic progenitors were injected. Encapsulated structures were found in the infarcted areas of a large fraction of hearts after injecting MSCs (22 of 43, 51.2%) and unfractionated BM cells (6 of 46, 13.0%). These formations contained calcifications and/or ossifications. In contrast, no pathological abnormalities were found after injection of purified hematopoietic progenitors (0 of 5, 0.0%), fibroblasts (0 of 5, 0.0%), vehicle only (0 of 30, 0.0%), or cytokine-induced mobilization of BM cells (0 of 35, 0.0%). We conclude that the developmental fate of BM-derived cells is not restricted by the surrounding tissue after myocardial infarction and that the MSC fraction underlies the extended bone formation in the infarcted myocardium. These findings seriously question the biologic basis and clinical safety of using whole BM and in particular MSCs to treat nonhematopoietic disorders.

  • 7.
    Buza-Vidas, Natalija
    et al.
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Antonchuk, Jennifer
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Qian, Hong
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Månsson, Robert
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Luc, Sidinh
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Zandi, Sasan
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Anderson, Kristina
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Takaki, Satoshi
    Department of Community Health and Medicine, Research Institute, International Medical Center of Japan, Tokyo, Japan.
    Nygren, Jens Martin
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Jensen, Christina T.
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Jacobsen, Sten Eirik W.
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Cytokines regulate postnatal hematopoietic stem cell expansion: Opposing roles of thrombopoietin and LNK2006Inngår i: Genes & Development, ISSN 0890-9369, E-ISSN 1549-5477, Vol. 20, nr 15, s. 2018-2023Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The role of cytokines as regulators of hematopoietic stem cell (HSC) expansion remains elusive. Herein, we identify thrombopoietin (THPO) and the cytokine signaling inhibitor LNK, as opposing physiological regulators of HSC expansion. Lnk(-/-) HSCs continue to expand postnatally, up to 24-fold above normal by 6 mo of age. Within the stem cell compartment, this expansion is highly selective for self-renewing long-term HSCs (LT-HSCs), which show enhanced THPO responsiveness. Lnk(-/-) HSC expansion is dependent on THPO, and 12-wk-old Lnk(-/-)Thpo(-/-) mice have 65-fold fewer LT-HSCs than Lnk(-/-) mice. Expansions of multiple myeloid, but not lymphoid, progenitors in Lnk(-/-) mice also proved THPO-dependent.

  • 8.
    Carlsson, Ing-Marie
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Patient participation, a prequisite for care: A grounded theory study of healthcare professionals’ perceptions of what participation means in a paediatric care context2018Inngår i: Nursing Open, E-ISSN 2054-1058, Vol. 5, nr 1, s. 45-52Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aims

    To explore healthcare professionals’ perceptions of what patient participation means in a paediatric care context.

    Design

    A qualitative explorative design with grounded theory.

    Methods

    Fifteen healthcare professionals who worked in paediatric care settings were either interviewed or asked open-ended questions in a survey, during December 2015–May 2016. Grounded theory was used as a method.

    Results

    The study results provide a theoretical conceptualization of what patient participation meant for healthcare professionals in paediatric care and how participation was enabled. The core category “participation a prerequisite for care” emerged as the main finding explaining the concept as ethical, practical and integrated in the care givers way of working. However, the concept was implicit in the organization. Four additional categories illustrated the healthcare professionals’ different strategies used to enhance patient participation; “meeting each child where the child is,” “building a relationship with the child,” “showing respect for each individual child” and “making the most of the moment.” © 2017 The Authors. Nursing Open published by John Wiley & Sons Ltd

  • 9.
    Einberg, Eva-Lena
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Kadrija, Ibadete
    Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS).
    Brunt, David
    Institutionen för Hälsa och Vårdvetenskap, Linnéuniversitetet, Växjö, Sweden.
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Psychometric evaluation of a Swedish version of Minneapolis-Manchester quality of life-youth form and adolescent form2013Inngår i: Health and Quality of Life Outcomes, ISSN 1477-7525, E-ISSN 1477-7525, Vol. 11, artikkel-id 79Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: It has become important to measure long-term effects and quality of life in survivors of childhood cancer. The Minneapolis- Manchester Quality of Life (MMQL) instrument has been proven to better capture the quality of life (QoL) perspective of health than other instruments. The instrument has age appropriate versions and is therefore favourable for longitudinal studies of QoL of children surviving from cancer. The aim of this study was to evaluate the psychometric properties of the Swedish version of MMQL-Youth Form and the Adolescent Form focusing on: 1) face and content validity 2) the internal consistency and 3) the test-retest reliability. Methods: The sample consisted of 950 pupils (11–16years old) from 7 schools in the western Sweden who completed the questionnaire. For the test-retest evaluation 230 respondents completed the questionnaire two weeks later. Results: Face and content validity was supported and internal consistency was found to be acceptable for the total scale for both the MMQL-Youth Form (8–12years of age) and the Adolescent Form (13–20years of age). Test-retest reliability for the MMQL-Youth Form was moderate for 50% of the items and good for the remaining. For the MMQL-Adolescent Form the test-retest showed moderate or good agreement for 80% of the items and fair for 20%. Conclusions: The result indicated that the Swedish version of the MMQLYouth Form and Adolescent Form was valid and reliable in a sample of healthy children in a Swedish context. It is recommended to test the instrument among diverse samples of children such as survivors of childhood cancer in order to validate its usefulness in research and clinical settings. © 2013 Einberg et al.; licensee BioMed Central Ltd.

  • 10.
    Einberg, Eva-Lena
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Enskär, Karin
    Jönköping University, Jönköping, Sweden.
    'Through my eyes': children with experience of cancer describing through photography what promotes their health2014Inngår i: Health Promotion Research - An International Forum <<Next Health>>, August 25-27,  2014, Trondheim, Norway, Trondheim: Senter for helsefremmende forskning HiST/NTNU , 2014, s. 33-33Konferansepaper (Fagfellevurdert)
  • 11.
    Einberg, Eva-Lena
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer. School of Health Sciences, Jönköping University, Jönköping, Sweden.
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Enskär, Karin
    School of Health Sciences, Jönköping University, Jönköping, Sweden.
    ‘Through my eyes’: health-promoting factors described by photographs taken by children with experience of cancer treatment2016Inngår i: Child Care Health and Development, ISSN 0305-1862, E-ISSN 1365-2214, Vol. 42, nr 1, s. 76-86Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    Health promotion for children with cancer should be based on the children's own needs and desires. Because there is a lack of knowledge in this area, the aim of this study was to explore what promotes health from the perspective of children with experience of cancer treatment.

    Methods

    Fifteen children between 8 and 12 years of age participated in focus groups with three children in each group. The children were given a camera and instructions to photograph subjects that promote their health. Focus group discussions were based on the photographs and the children's own description of those photographs. The analysis of focus group discussions and photographs was conducted using inductive content analysis.

    Results

    According to the children, health-promoting factors are defined as meaningful relationships, recreational activities and a trustful environment. Meaningful relationships include togetherness within the family, affection for pets and friendship with peers. Recreational activities include engagement in play and leisure, withdrawal for relaxation and feeling enjoyment. Trustful environment includes confidence in significant others and feeling safe.

    Conclusions

    Knowledge from this study can contribute to health promotion interventions and quality improvements in the health care of children with experience of cancer treatment. Children's experiences with what promotes health in their everyday lives provide a better understanding of the type of support children prefer when promoting their own health. © 2015 John Wiley & Sons Ltd.

  • 12.
    Einberg, Eva-Lena
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Enskär, Karin
    Hälsohögskolan i Jönköping, Jönköping, Sweden.
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Friendship from the perspective of children with experience of cancer: A focus group study2013Inngår i: Pediatric Blood & Cancer, ISSN 1545-5009, E-ISSN 1545-5017, Vol. 60, nr suppl. 3, s. 43-43Artikkel i tidsskrift (Fagfellevurdert)
  • 13.
    Einberg, Eva-Lena
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer. School of Health Sciences, Jönköping University, Jönköping, Sweden.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Enskär, Karin
    School of Health Sciences, Jönköping University, Jönköping, Sweden.
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Friendship Relations From the Perspective of Children With Experience of Cancer Treatment: A Focus Group Study With a Salutogenic Approach2015Inngår i: Journal of Pediatric Oncology Nursing, ISSN 1043-4542, E-ISSN 1532-8457, Vol. 32, nr 3, s. 153-164Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Friendships are significant to child development and health but diseases such as cancer can interrupt the contact with friends. The purpose of this study was to describe perceptions of friendship from the perspective of children undergoing cancer treatment, in order to build knowledge that can be used in a health promotion intervention for these children. Fifteen children between 8 and 12 years of age participated in focus groups, where a mixture of informative and creative techniques were used. The focus group discussions were analyzed using qualitative content analysis. The analysis resulted in three generic categories, “Common interests and experiences,” “Mutual empathic actions.” and “Mutual trust and understanding,” incorporating seven subcategories. Based on children’s descriptions from a salutogenic perspective, friendship emerged as An equal and mutual commitment that evolves over time and with interactions face-to-face and digitally, a child perspective on friendship should be central to the development of health promotion interventions designed to support friendship relations of children treated for cancer. © 2014 by Association of Pediatric Hematology/Oncology Nurses

  • 14.
    Einberg, Eva-Lena
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Wärnestål, Pontus
    Thomsen, Michel
    Stigmar, Jennie
    Barnonkologiskt centra, Skånes Universitetssjukhus i Lund, Lund, Sverige.
    Enskär, Karin
    Högskolan i Jönköping, Hälsohögskolan, Jönköping, Sverige.
    Åkesson, Maria
    Nygren, Jens
    Hur gör man barn delaktiga i forsknings- och innovationsprocesser vid utveckling av digitala hälsoinnovationer2013Konferansepaper (Fagfellevurdert)
    Abstract [sv]

    Att drabbas av en svår eller kronisk sjukdom under barndomen kan bidra till fysiska och psykosociala svårigheter senare i livet. Kamratstöd mellan individer som delar samma erfarenhet är en viktig främjande faktor till hälsa och välbefinnande och kan verka som en buffert mot stress och motgångar. Empirisk evidens som kan vägleda utveckling av digitala och interaktiva lösningar för kamratstöd mellan barn som drabbas av sjukdom i skolåldern är idag begränsad. Den process som presenteras här är fokuserad på att etablera metodologi för barns delaktighet i innovationsprocesser och att fånga barns bakomliggande beteenden och mål relaterat till kamratstödjande processer och hälsa. Intervjuer i fokusgrupper är en teknik som främjar barns deltagande och fångar barns perspektiv, förståelse och erfarenhet relaterat till deras hälsa. Friska barn (8-12 år) rekryterades från en lokal grundskola till fyra fokusgrupper med fyra barn i varje grupp. Barnen träffades två gånger med en intervall på 1-2 veckor. Förändringar gjordes mellan varje fokusgrupp för att anpassa strukturen på träffarna till en nivå motsvarande barnens erfarenheter, ålder och förmåga och för att fokusera diskussionerna på innovationsprocessen. En blandning av informativa och kreativa tekniker som öppna frågor, brainstorming, rita och måla och fotografering användes för att underlätta för barnen att uttrycka sig. Barnen framförde efter deltagandet att de tyckte om att delta och ville träffas igen i den här formen av grupp. Vår anpassade struktur på fokusgrupper används idag med barn med erfarenhet av svår sjukdom (cancer) för att ta fram typanvändare (Personas) i innovationsprocessen. Barnen rekryterades från Barnonkologiskt centra i Lund och Hallands sjukhus i Halmstad till fem fokusgrupper med tre barn i varje grupp. Barns delaktighet genom vår metod har förbättrat förutsättningarna att fånga barns mål och beteende och tillfört unikt material till den fortsatta designprocessen.

  • 15.
    Einberg, Eva-Lena
    et al.
    Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Wärnestål, Pontus
    Högskolan i Halmstad, Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE), Halmstad Embedded and Intelligent Systems Research (EIS), Människa och Informationsteknologi (MI-lab).
    Thomsen, Michel
    Högskolan i Halmstad, Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE), Halmstad Embedded and Intelligent Systems Research (EIS), Människa och Informationsteknologi (MI-lab).
    Stigmar, Jennie
    Barnonkologiskt centra, Skånes Universitetssjukhus i Lund, Lund, Sverige.
    Enskär, Karin
    Avd. för omvårdnad, Hälsohögskolan, Högskolan i Jönköping, Jönköping, Sverige.
    Åkesson, Maria
    Högskolan i Halmstad, Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE), Halmstad Embedded and Intelligent Systems Research (EIS), Människa och Informationsteknologi (MI-lab).
    Nygren, Jens
    Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Hur gör man barn delaktiga i forsknings- och innovationsprocesser vid utveckling av digitala hälsoinnovationer2012Konferansepaper (Fagfellevurdert)
    Abstract [sv]

    Att drabbas av en svår eller kronisk sjukdom under barndomen kan bidra till fysiska och psykosociala svårigheter senare i livet. Kamratstöd mellan individer som delar samma erfarenhet är en viktig främjande faktor till hälsa och välbefinnande och kan verka som en buffert mot stress och motgångar. Empirisk evidens som kan vägleda utveckling av digitala och interaktiva lösningar för kamratstöd mellan barn som drabbas av sjukdom i skolåldern är idag begränsad. Den process som presenteras här är fokuserad på att etablera metodologi för barns delaktighet i innovationsprocesser och att fånga barns bakomliggande beteenden och mål relaterat till kamratstödjande processer och hälsa. Intervjuer i fokusgrupper är en teknik som främjar barns deltagande och fångar barns perspektiv, förståelse och erfarenhet relaterat till deras hälsa. Friska barn (8-12 år) rekryterades från en lokal grundskola till fyra fokusgrupper med fyra barn i varje grupp. Barnen träffades två gånger med en intervall på 1-2 veckor. Förändringar gjordes mellan varje fokusgrupp för att anpassa strukturen på träffarna till en nivå motsvarande barnens erfarenheter, ålder och förmåga och för att fokusera diskussionerna på innovationsprocessen. En blandning av informativa och kreativa tekniker som öppna frågor, brainstorming, rita och måla och fotografering användes för att underlätta för barnen att uttrycka sig. Barnen framförde efter deltagandet att de tyckte om att delta och ville träffas igen i den här formen av grupp. Vår anpassade struktur på fokusgrupper används idag med barn med erfarenhet av svår sjukdom (cancer) för att ta fram typanvändare (Personas) i innovationsprocessen. Barnen rekryterades från Barnonkologiskt centra i Lund och Hallands sjukhus i Halmstad till fem fokusgrupper med tre barn i varje grupp. Barns delaktighet genom vår metod har förbättrat förutsättningarna att fånga barns mål och beteende och tillfört unikt material till den fortsatta designprocessen.

  • 16.
    Einberg, Eva-Lena
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Wärnestål, Pontus
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Thomsen, Michel
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Stigmar, Jennie
    Barnonkologiskt centra, Skånes Universitetssjukhus i Lund, Sverige.
    Enskär, Karin
    Högskolan i Jönköping, Hälsohögskolan, Avd. för omvårdnad, Jönköping, Sverige.
    Åkesson, Maria
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Involving children in research and innovation processes in the development of digital health promotion intervention2013Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Introduction

    Severe or chronic illness in childhood may contribute to physical and psychosocial problems later in life. Peer support among individuals who share the same experience is an important factor in promoting health and wellbeing and can act as a buffer against stress and adversities. Empirical evidence that could guide development of digital and interactive solutions for peer support between school-aged children affected by illness is limited.

    Purpose/Methods

    The process presented here is focused on establishing method- ology for children's participation in innovation processes and to capture the child's underlying behaviors and goals related to peer support processes and health. Focus group interview is a child-friendly method that promotes participation and access to children's perspectives, insights and experiences related to their health. Healthy children were recruited from a local elementary school. Focus groups were carried out in two sessions for each group with an interval of 1-2 weeks.

    Results

    Adjustments were made between each focus group to adapt the meeting structure to a level commensurate with the chil- dren's experience, age and abilities and to focus discussions on innovation incentives related to a digital peer support service. A mixture of informative and creative techniques such as open questions, brainstorming, drawing and painting and photog- raphy were used to assist the children to express themselves. The children were pleased to participate and wanted to meet again in this form of group.

    Conclusions

    Our adapted focus group structure are now being used with children with experience of severe illness (cancer) to develop Personas (fictitious characters of users) in the innovation pro- cess. Children's participation through our method has improved the chances of capturing children's goals and behavior, and added unique material for the continuing design process. 

  • 17.
    Einberg, Eva-Lena
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Wärnestål, Pontus
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), Människa och Informationsteknologi (MI-lab).
    Thomsen, Michel
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), Människa och Informationsteknologi (MI-lab).
    Stigmar, Jennie
    Skåne University Hospital, Lund, Sweden.
    Enskär, Karin
    Jönköping University, Jönköping, Sweden.
    Åkesson, Maria
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), Människa och Informationsteknologi (MI-lab).
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Participatory innovation process for development of a digital peer support service for children with cancer2012Inngår i: SIOP Publication Abstracts, Hoboken, NJ: John Wiley & Sons, 2012, s. 88-88Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Purpose: Surviving cancer during childhood imposes a number of difficulties later in life. Peer support has been recognised as an important contributor to health and well-being but empirical evidence that could guide development of peer support programs for school aged children is scarce. The process presented here is focused on generic exploration of children’s needs and expectations related to peer support innovations to promote health and wellbeing of children with cancer. The purpose of this study is to establish a participatory innovation process that grasps the underlying behaviours and goals of children that will affect the design of a digital peer support service.

    Methods: Focus group interview is a child-friendly technique that promotes participation and access to children’s perspectives, insights and experiences related to their health. Healthy children 8–12 years of age were recruited from a local elementary school. Focus groups (n = 5 groups) were carried out in two sessions for each group (n = 4 children per group) with an interval of 1–2 weeks. Adjustments were made between each focus group to adapt the meeting structure to a level commensurate with the children’s experience, age and abilities and to focus discussions on innovation incentives related to a digital peer support service.

    Results: The adaptation process involved adjustments of the focus group structure to match children in the selected age group and to the aims of the innovation process. A mixture of informative and creative techniques (open questions, brainstorming, drawing, photography) assisted the children in talking and expressing themselves. The children were pleased to participate and wanted to meet again in this kind of study group. The adapted focus group sessions are now being used in the research and innovation process with children (8–12 yrs) with experience of cancer treatment.

    Conclusion: The final focus group structure capture children’s perspectives for the design of a digital peer support service.

  • 18.
    Einberg, Eva-Lena
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Wärnestål, Pontus
    Thomsen, Michel
    Stigmar, Jennie
    Enskär, Karin
    Åkesson, Maria
    Nygren, Jens Martin
    Participatory innovation process for development of a digital peer support service for children with cancer2012Inngår i: NOPHO NOBOS Meeting and Congress Uppsala, Sweden, May 19 – 22, 2012: Programme and Abstract Book, 2012, s. 118-118Konferansepaper (Fagfellevurdert)
  • 19.
    Garell, Cecilia
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    A Legal Framework to Support Development and Assessment of Digital Health Services2016Inngår i: JMIR medical informatics, ISSN 2291-9694, Vol. 4, nr 2, s. e17-e17Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Digital health services empower people to track, manage, and improve their own health and quality of life while delivering a more personalized and precise health care, at a lower cost and with higher efficiency and availability. Essential for the use of digital health services is that the treatment of any personal data is compatible with the Patient Data Act, Personal Data Act, and other applicable privacy laws.

    OBJECTIVE: The aim of this study was to develop a framework for legal challenges to support designers in development and assessment of digital health services.

    METHODS: A purposive sampling, together with snowball recruitment, was used to identify stakeholders and information sources for organizing, extending, and prioritizing the different concepts, actors, and regulations in relation to digital health and health-promoting digital systems. The data were collected through structured interviewing and iteration, and 3 different cases were used for face validation of the framework.

    RESULTS: A framework for assessing the legal challenges in developing digital health services (Legal Challenges in Digital Health [LCDH] Framework) was created and consists of 6 key questions to be used to evaluate a digital health service according to current legislation.

    CONCLUSIONS: Structured discussion about legal challenges in relation to health-promoting digital services can be enabled by a constructive framework to investigate, assess, and verify the digital service according to current legislation. The LCDH Framework developed in this study proposes such a framework and can be used in prospective evaluation of the relationship of a potential health-promoting digital service with the existing laws and regulations.

  • 20.
    Garell, Cecilia
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Lagutrymmet för hälsofrämjande e-tjänster i förhållande till hälso- och sjukvården2014Rapport (Annet vitenskapelig)
  • 21.
    Gilljam, Britt-Mari
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Arvidsson, Susann
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Nygren, Jens M.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Child participation in health care (ChiPaC)—Development and psychometric evaluation of a self‐report instrument for children's participation in health care2019Inngår i: Journal of Clinical Nursing, ISSN 0962-1067, E-ISSN 1365-2702, s. 1-12Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aims and objectives

    To develop and evaluate the psychometric properties of a self‐report instrument measuring 6‐ to 12‐year‐old children's own experiences of participation in health care.

    Background

    Validated measures to evaluate children's participation in health care can play a critical role in strategic work towards supporting children's participation at an individual level and in working towards quality improvements at an organisational level. There are, however, no available instruments to achieve this.

    Methods

    An instrument development design was used, together with the TRIPOD checklist. Item construction was based on research about children's perspectives on participation in health care and Shier's model for participation. The face and content validity was evaluated by 14 healthy children, 9 paediatric nurses and 8 children with different diseases. The construct validity, internal consistency and stability reliability were evaluated based on data from 138 children visiting a paediatric clinic.

    Results

    The testing of the face and content validity resulted in an instrument with child‐friendly language, additional instructions and visual attractive presentation. The principle component analysis resulted in the four‐factor solution: “To be included,” “To trust professionals,” “To take control,” and “To understand information.” Internal consistency and intraclass correlation coefficients were acceptable.

    Conclusion

    We conclude that the child participation in health care (ChiPaC) instrument has adequate reliability and validity when used to evaluate children's participation in health care. The involvement of children in the development of ChiPaC resulted in a brief, colourful and user‐friendly instrument for use in paediatric health care.

    Relevance to clinical practice

    This new questionnaire, ChiPaC, is adapted for children between 6–12 years measuring participation in health care from a child perspective. ChiPaC can be used in the practical work of supporting individual children's participation in health care as well as in the strategical work towards quality improvements on an organisational level.

    What does this paper contribute to the wider global clinical community?

    • The instrument provides a contribution for the practical implementation of the Convention on the Rights of the Child in health care.
    • The high degree of involvement of children in the development of the instrument resulted in a brief, colourful and user‐friendly instrument that can be used in paediatric health care.
    • The instrument can play a critical role in the practical work of supporting individual children's participation in health care as well as in the strategical work of quality improvement on an organisational level.
  • 22.
    Gilljam, Britt-Mari
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Arvidsson, Susann
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Involving Children with Juvenile Idiopathic Arthritis in Health-Related Research – Why and How?2015Inngår i: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 74, nr Suppl. 2, s. 1312-1312Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Children with severe Juvenile idiopathic arthritis (JIA) are exposed to care situations and harsh treatments such as intra-articular corticosteroid injections (1). In order for these children to feel confidence, it is important they understand and feel they have control over the situation. To support the wellbeing of these children and their involvement in care, it is important to investigate their views of the care process and their everyday life (2).

    Objectives: The purpose of this study is to describe our experiences of using different activities and techniques during interviews with children with JIA.

    Methods: Children (n=23) from two rheumatic pediatric clinics in Sweden, age 8 - 17, diagnosed with JIA since at least two years were interviewed individually or in focus groups. All interviews focused on experiences and preferences of participating in care situations. Among the younger children, age 8 - 12, we used activities such as sentence completion, to express three wishes, draw and tell, and role-play with Barbie dolls. Among the older ones, age 13 – 17, we used sentence completion, to express three wishes and post-IT tabs for brainstorming and subsequent discussion. During all interviews we used open-ended questions.

    Results: Sentence completion and three wishes were two weak techniques for most of the children regardless of age. The younger children often responded to these techniques with silence or responses like “I don't know”. The older children responded with intense reflection and thinking, and predominately came up with one wish only. Techniques that were powerful in activating discussions were draw and tell and role-play with Barbie dolls for the younger children. Using Post-IT tabs and discussions was a good starter for discussions for the older children in focus groups.

    Conclusions: There is reason to reflect on what techniques researchers use when interviewing children, as the prospects of capturing children's perspectives in research is largely dependent on the researcher's ability to engage children in the interview situation. Different interview methods should be used depending on the age of the informants, the purpose of the investigation, and the capabilities, such as the health status, of the child. In this study, we experienced that the participants ability to express their experiences and preferences can be facilitated with practical techniques, like drawing and role-play with Barbie dolls for younger children and Post-IT tabs for children in older age groups.

    References:

    Bertilsson L. Andersson-Gäre B. Fasth A. Forsblad-d'Elia H. A 5-year prospective population-based study of juvenile chronic arthritis: onset, disease process, and outcome. Scandinavian journal of rheumatology 2012; 41(5): 379-382.

    Coyne I. Hayes E. Gallagher P. Regan G. Giving children a voice: investigation of children's experiences of participation in consultation and decision-making in Irish hospitals. Office of the Minister for Children 2006; 3576.

    Acknowledgements: Thanks to: The Swedish Rheumatic Foundation, Stig Thunes Foundation and Norrbacka Eugenia Foundation.

    Disclosure of Interest: None declared

  • 23.
    Gilljam, Britt-Mari
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Arvidsson, Susann
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Promoting participation in healthcare situations for children with JIA: a grounded theory study2016Inngår i: International Journal of Qualitative Studies on Health and Well-being, ISSN 1748-2623, E-ISSN 1748-2631, Vol. 11, artikkel-id 30518Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Children’s right to participate in their own healthcare has increasingly become highlighted in national and international research as well as in government regulations. Nevertheless, children’s participation in healthcare is unsatisfactorily applied in praxis. There is a growing body of research regarding children’s participation, but research from the children’s own perspective is scarce. The aim of this study was thus to explore the experiences and preferences for participation in healthcare situations among children with juvenile idiopathic arthritis (JIA) as a foundation for creating strategies to promote their participation in pediatric healthcare. Twenty children, aged 8 to 17 years, with JIA were interviewed individually and in focus groups. In order to increase the children’s opportunities to express their own experiences, different interview techniques were used, such as draw-and-tell and role play with dolls. The analysis was conducted with a constructivist grounded theory. The result explores children’s perspective of influencing processes promoting their participation in healthcare situations. The core category that emerged was, “Releasing fear and uncertainty opens up for confidence and participation,” and the categories related to the core category are, “surrounded by a sense of security and comfort,” and “strengthened and supported to become involved.” In conclusion, the knowledge gained in this study offers new insights from the perspective of children themselves, and can constitute a valuable contribution to the understanding of necessary conditions for the development of specific interventions that promote participation among children in healthcare situations.

  • 24.
    Hutton, Katrin
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer. Affecta Psychiatric clinic, Halmstad, Sweden.
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Nyholm, Maria
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Idrott, hälsa och fysisk aktivitet.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Low self-rated mental health among Swedish adolescent boys and its relationship to socioeconomic factors2013Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Background

    Adolescents mental health is a major public health concern and studies have shown that socioeconomic factors contribute to the experienced health of adolescents. Girls’ mental health, more than boys’ mental health, is often discussed. Therefore, the aim of this study was to investigate the association between self-rated mental health and socioeconomic factors among boys and we hypothesized that household wealth influences the association.

    Methods

    In 2011, a cross-sectional study was conducted at seven junior high schools in a medium sized town in south western Sweden. The data collected was based on a self-administrated questionnaire regarding socioeconomic factors, household wealth and health related quality of life (Minnesota Minneapolis Quality of Life Instrument (MMQL). In all, 235 boys between 11-13 years old and 254 boys between 14-16 years participated. The items from MMQL were summarized into a total score and dichotomized by the median and low self-rated mental health was defined as below median. Logistic regression analysis was used.

    Results

    Among younger boys no association between low self-rated mental health and socioeconomic factors were seen. Among older boys with divorced parents, an increased risk of low mental health rating was seen OR: 1.83 (95%CI, 1.04;3.23), however when adjusting for household wealth the association disappeared (OR;1.76, CI 0.98;3.15). Also, having one or two parents born outside Sweden implied increased risk of a low self-rated mental health OR: 2.0 (CI; 1.15;3.47), which remained when adjusting for household wealth variables (OR; 2.16 CI; 1.17;3.99). Furthermore, having two or more negative socioeconomic variables increased the risk of low rated mental health (OR;2.60, CI 1.15;5.90) the association remained after adjusting for household wealth (OR;2.38, CI 1.03;5.33).

    Conclusions

    Boys with divorced parents, boys from migrant backgrounds and boys with several negative socioeconomic factors constituted the identified subgroups at risk. More research in public health is essential to meet the special needs of different age groups and backgrounds among adolescent boys.

    Key messages

    • Among older boys (14-16 years old) with divorced parents, an increased risk of low mental health rating was seen, however when adjusting for household wealth the association disappeared.
    • Among older boys (14-16 years old) having two or more negative socioeconomic variables increased the risk of low rated mental health, the association remained after adjusting for household wealth.

    © The Author 2013. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

  • 25.
    Hutton, Katrin
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer. Affecta psychiatric out-patients clinic, Halmstad, Sweden.
    Nyholm, Maria
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Idrott, hälsa och fysisk aktivitet.
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Kadrija, Ibadete ()
    Högskolan i Halmstad, Akademin för hälsa och välfärd.
    Self-rated mental health and socio-economic background: a study of adolescents in Sweden2014Inngår i: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 14, nr 1, artikkel-id 394Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Adolescents' mental health is a major public health issue. Previous research has shown that socio-economic factors contribute to the health status of adolescents. The present study explores the association between socio-economic status and self-rated mental health among adolescents.

    Methods: Cross sectional data from the Halmstad Youth Quality of Life cohort was collected in a town in Sweden. In all, 948 adolescents (11-13 younger age group and 14-16 older age group) participated. Information on self-rated mental health was collected from the subscale Psychological functioning in the Minneapolis Manchester Quality of Life instrument. The items were summarized into a total score and dichotomized by the mean. Indicators measuring socio-economic status (SES) were collected in a questionnaire using the Family Affluence Scale (FAS) and additional factors regarding parents' marital status and migration were added. Logistic models were used to analyze the data.

    Results: Girls were more likely to rate their mental health below the mean compared to boys. With regard to FAS (high, medium, low), there was a significantly increased risk of self-rated mental health below the mean among younger boys in the medium FAS score OR; 2.68 (95% CI 1.35;5.33) and among older boys in the low FAS score OR; 2.37 (1.02;5.52) compared to boys in the high FAS score. No such trend was seen among girls. For younger girls there was a significant protective association between having parents born abroad and self-rated mental health below mean OR: 0.47 (0.24;0.91).

    Conclusions: A complex pattern of associations between SES and self-rated mental health, divergent between age and gender groups, was shown. The total FAS score was only associated with boys' self-rated mental health in both age groups, whereas parents' migratory status influenced only the girls' self-rated mental health. Because of the different association for girls' and boys' self-rated mental health and SES, other factors than SES should also be considered when investigating and exploring the mental health of adolescents in affluent communities. © 2014 Hutton et al.; licensee BioMed Central Ltd.

  • 26.
    Häggström Westberg, Katrin
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI). Affecta Psychiatric Out-Patients Clinic, Halmstad, Sweden.
    Wilhsson, Marie
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Morgan, Antony
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI). Glasgow Caledonian University, Glasgow, United Kingdom.
    Nyholm, Maria
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Optimism as a Candidate Health Asset: Exploring Its Links with Adolescent Quality of Life in Sweden2019Inngår i: Child Development, ISSN 0009-3920, E-ISSN 1467-8624, Vol. 90, nr 3, s. 970-984Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This study aims to understand the role that optimism could play in the context of a health asset approach to promote adolescent health-related quality of life (HRQOL). Adolescents (n = 948), between 11 and 16 years old from a medium-sized rural town in Sweden, answered questionnaires measuring optimism, pessimism, and HRQOL. The findings indicate a significant decrease in optimism and a significant increase in pessimism between early and mid adolescence. The study has allowed us to present associational evidence of the links between optimism and HRQOL. This infers the potential of an optimistic orientation about the future to function as a health asset during adolescence and by implication may provide additional intervention tools in the planning of health promotion strategies. © 2017 The Authors

  • 27.
    Häggström Westerberg, Katrin
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Wilhsson, Marie
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Antony, Morgan
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI). Glasgow Caledonian University, Glasgow, United Kingdom.
    Nyholm, Maria
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Exploring the role of optimism as a protective factor for adolescent quality of lifeManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    This study attempts to understand the role that optimism could play in the context of a health asset approach to promote (and protect) adolescent health related quality of life (HRQOL).  Two hypotheses were formulated, a) there is an association between adolescents’ self-rated optimism and pessimism and their HRQOL, (b) age, gender and socio-demographic characteristics influence this association. We explore optimism and pessimism as a bi-dimensional construct and its impact on HRQOL among adolescents in two age groups (11-13 years and 14-16 years). Adolescents answered a self-report questionnaire consisting of two validated scales for measuring HRQOL and the concepts of optimism and pessimism. This study has shown that optimism is an important protective factor for HRQOL and low levels of pessimism were also seen to be protective of HRQOL in both age groups.  This infers the potential of an optimistic orientation about future goals might function as a health asset during adolescence that could be useful in the planning of health promotion strategies.

  • 28.
    Kolossov, Eugen
    et al.
    Axiogenesis AG, 50931 Cologne, Germany.
    Bostani, Toktam
    Institute of Physiology I, University of Bonn, 53105 Bonn, Germany.
    Roell, Wilhelm
    Department of Cardiac Surgery, University of Bonn, 53105 Bonn, Germany.
    Breitbach, Martin
    Institute of Physiology I, University of Bonn, 53105 Bonn, Germany.
    Pillekamp, Frank
    Institute of Neurophysiology, University of Cologne, 50931 Cologne, Germany.
    Nygren, Jens Martin
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, 221 00 Lund, Sweden .
    Sasse, Philipp
    Institute of Physiology I, University of Bonn, 53105 Bonn, Germany.
    Rubenchik, Olga
    Institute of Neurophysiology, University of Cologne, 50931 Cologne, Germany.
    Fries, Jochen W U
    Department Pathology, University of Cologne, 50931 Cologne, Germany.
    Wenzel, Daniela
    Institute of Physiology I, University of Bonn, 53105 Bonn, Germany.
    Geisen, Caroline
    Institute of Physiology I, University of Bonn, 53105 Bonn, Germany.
    Xia, Ying
    Institute of Neurophysiology, University of Cologne, 50931 Cologne, Germany.
    Lu, Zhongju
    Institute of Neurophysiology, University of Cologne, 50931 Cologne, Germany.
    Duan, Yaqi
    Institute of Neurophysiology, University of Cologne, 50931 Cologne, Germany.
    Kettenhofen, Ralf
    Axiogenesis AG, 50931 Cologne, Germany.
    Jovinge, Stefan
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, 221 00 Lund, Sweden.
    Bloch, Wilhelm
    German Sports University, 50927 Cologne, Germany.
    Bohlen, Heribert
    Axiogenesis AG, 50931 Cologne, Germany.
    Welz, Armin
    Department of Cardiac Surgery, University of Bonn, 53105 Bonn, Germany.
    Hescheler, Jürgen
    Institute of Neurophysiology, University of Cologne, 50931 Cologne, Germany.
    Jacobsen, Sten Eirik
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, 221 00 Lund, Sweden.
    Fleischmann, Bernd K
    Institute of Physiology I, University of Bonn, 53105 Bonn, Germany.
    Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium2006Inngår i: Journal of Experimental Medicine, ISSN 0022-1007, E-ISSN 1540-9538, Vol. 203, nr 10, s. 2315-2327Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cellular cardiomyoplasty is an attractive option for the treatment of severe heart failure. It is, however, still unclear and controversial which is the most promising cell source. Therefore, we investigated and examined the fate and functional impact of bone marrow (BM) cells and embryonic stem cell (ES cell)-derived cardiomyocytes after transplantation into the infarcted mouse heart. This proved particularly challenging for the ES cells, as their enrichment into cardiomyocytes and their long-term engraftment and tumorigenicity are still poorly understood. We generated transgenic ES cells expressing puromycin resistance and enhanced green fluorescent protein cassettes under control of a cardiac-specific promoter. Puromycin selection resulted in a highly purified (>99%) cardiomyocyte population, and the yield of cardiomyocytes increased 6-10-fold because of induction of proliferation on purification. Long-term engraftment (4-5 months) was observed when co-transplanting selected ES cell-derived cardiomyocytes and fibroblasts into the injured heart of syngeneic mice, and no teratoma formation was found (n = 60). Although transplantation of ES cell-derived cardiomyocytes improved heart function, BM cells had no positive effects. Furthermore, no contribution of BM cells to cardiac, endothelial, or smooth muscle neogenesis was detected. Hence, our results demonstrate that ES-based cell therapy is a promising approach for the treatment of impaired myocardial function and provides better results than BM-derived cells.

  • 29.
    Larsson, Ingrid
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Nyman, Carin
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Carlsson, Ing-Marie
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Children and young people’s participation in developing interventions in health and well-being: a scoping review2018Inngår i: BMC Health Services Research, ISSN 1472-6963, E-ISSN 1472-6963, Vol. 18, nr 507Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Background: Greater interest is being shown in participatory approaches, especially in research on interventions that concern children and young people'shealth and well-being. Although participatory approaches have user involvement in common, they differ in terms of the explicit guidance on how to actually involve and engage children and young people in health research. The aim of this scoping review was to systematically map recent research involving children and young people in the development of interventions targeting issues of health and well-being. Methods: An interpretative scoping literature review based on: a scientific literature search in (health and social science) databases, reference lists, a manual search in key journals and contact with existing networks was conducted. A total of 4458 references were identified through the literature search, of which 41 studies published between 2000 and 2017 were included in the review. The target population was children and young people under 25 years old. Level of participation was categorized according to Shier's Pathways to Participation Model. Results: The review showed that participatory approaches were most often used in the development of interventions in school settings and in community and healthcare settings and on issues concerning support in lifestyle or in managing illness or disease. The level of participation varied from children and young people taking part just as active informants, through stages of greater participation both in quantitative and qualitative terms, to children and youngpeople becoming an active agent involved as a co-researcher where the research process was shaped by views of a higher level of mutuality. Most of the studies were categorised at a medium level and only three studies were judged to involve the children and young people at the highest level. Conclusions: This scoping review showed that work remains in enabling children and young people to influence the development of interventions targeting health and well-being. In relation to level of sustainability in the interventions, it is relevant that goals, strategies and processes are formulated by those who can gain from the interventions. Participatory approaches aiming for a higher level of participation where children and young people work together with the researchers in partnerships are thus warranted. © 2018 The Author(s).

  • 30.
    Larsson, Ingrid
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Arvidsson, Susann
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Carlsson, Ing-Marie
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Parents’ experiences of an e-health intervention implemented in pediatric healthcare: a qualitative study2019Inngår i: BMC Health Services Research, ISSN 1472-6963, E-ISSN 1472-6963, Vol. 19, artikkel-id 800Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The growing field of participation in healthcare has the potential to provide a number of benefits for children, patients, healthcare professionals and also the healthcare systems. According to the Convention on the Rights of the Child (UNCRC), children have the right to participate in their own healthcare and make their voice heard. Children’s opportunities for understanding their conditions, sharing their views and participating in decisions regarding their care depend on healthcare professionals but also on parents’ ability to communicate and include children. E-health solutions can remove barriers to children’s communication with healthcare professionals. The aim of this study was to explore parents’ perspectives on the outcomes of an e-health solution, Sisom, used by children during healthcare appointments.

    Methods: The empirical data is based on interviews with 16 parents. In the present study constructivist, grounded theory was chosen as the method.

    Results: The theory of enhancing participation, by orientating communication about healthcare towards the voice of the child instead of the parents, summarizes the process of how the outcome of Sisom for children lead to enhanced participation, by making the child the main actor and an agent in his/her own healthcare. The facilitators for achieving participation in Sisom were four interrelated outcomes; engaging, voice-guarding, raising awareness and integrity preserving. In addition to generating increased participation, it emerged that the use of Sisom also initiated a process, which was evident in all four subcategories that facilitated the child in coping with the experience of having an illness.

    Conclusions: We conclude, that Sisom orientated communication about healthcare towards the voice of the child instead of the parents as well as including the child in the dialogue with the healthcare professional and thus increasing the child’s participation and human rights. © 2019 BioMed Central Ltd unless otherwise stated. Part of Springer Nature.

  • 31.
    Lindberg, Susanne
    et al.
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), Människa och Informationsteknologi (MI-lab).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Bergquist, Magnus
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), Människa och Informationsteknologi (MI-lab).
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Evaluating Digital Peer Support for Children Cured from Cancer2017Inngår i: International Journal of Human-Computer Interaction, ISSN 1044-7318, E-ISSN 1532-7590, Vol. 33, nr 8, s. 664-676Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article describes a case study of the challenges that emerged from a formative evaluation process with the purpose of evaluating a digital peer support (DPS) service for children between 8 and 12 cured from cancer. The evaluation of DPS for children is particularly challenging. While the literature on evaluation with children is extensive, challenges such as risk assessment that become prevalent in the evaluation of DPS are not highlighted. This case study analyzes how the DPS service was evaluated over the course of two usability tests, a two-week diary study, a focus group interview, and a survey. Challenges relating to ethics, trust, risk assessment, and recruitment emerged during the evaluation process. We identify key strategies to handle these challenges: progression, proxies, and reflection. Performing a multistage evaluation process with progressing sensitivity allowed control of some of the complexities of the context in order to balance the degree of the children’s involvement with the degree of sensitivity. © 2017 Taylor & Francis Group, LLC

  • 32.
    Lindberg, Susanne
    et al.
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), Människa och Informationsteknologi (MI-lab).
    Wärnestål, Pontus
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), Människa och Informationsteknologi (MI-lab).
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Designing digital peer support for children: design patterns for social interaction2014Inngår i: IDC '14 Proceedings of the 2014 conference on Interaction design and children, [S.l.]: ACM Press, 2014, s. 47-56Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Children who have survived a life-threatening disease like cancer benefit from social support from other children with a similar background. However, these children are often geographically dispersed and have little opportunity to meet. We investigate the design and development of Digital Peer Support Services (DPS), which may overcome this problem. Peer support is a kind of social support that brings together peers with similar experiences to help their adjustment to a disease. The aim of this paper is to develop design patterns for social interaction that can be implemented in a DPS for children surviving cancer. We conducted four sets of design workshops with children, from which emerged clusters relating to peer support and friendship that were broken down into triads. From these, six design patterns for social interaction were developed. The patterns delineate different aspects of social interaction for children and are illustrated with examples from DPS prototypes and concepts. The patterns are organized into a hierarchy, comprising the beginning of a design pattern language for social interaction for children. An essential aspect of the patterns is providing users with transparency and control of the extent to which their social interaction is public or private. Copyright © 2014 ACM.

  • 33.
    Morgan, Antony
    et al.
    Glasgow Caledonian University, London, United Kingdom.
    Nygren, Jens M.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Nyholm, Maria
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Social capital as a theory of change for young people’s health: a scoping review preliminary findings2017Inngår i: European Journal of Public Health, ISSN 1101-1262, E-ISSN 1464-360X, Vol. 27, nr Suppl. 3, s. 85-85, artikkel-id ckx187.217Artikkel i tidsskrift (Fagfellevurdert)
  • 34.
    Norddahl, Gudmundur L.
    et al.
    Immunology Section, Institution for Experimental Medical Science, Lund University, Lund, Sweden.
    Pronk, Cornelis J.
    Immunology Section, Institution for Experimental Medical Science, Lund University, Lund, Sweden.
    Wahlestedt, Martin
    Immunology Section, Institution for Experimental Medical Science, Lund University, Lund, Sweden.
    Sten, Gerd
    Immunology Section, Institution for Experimental Medical Science, Lund University, Lund, Sweden.
    Nygren, Jens M.
    Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Ugale, Amol
    Immunology Section, Institution for Experimental Medical Science, Lund University, Lund, Sweden.
    Sigvardsson, Mikael
    Institution of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    Bryder, David
    Immunology Section, Institution for Experimental Medical Science, Lund University, Lund, Sweden.
    Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging2011Inngår i: Cell Stem Cell, ISSN 1934-5909, E-ISSN 1875-9777, Vol. 8, nr 5, s. 499-510Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age. Identifying the mechanisms underlying age-dependent stem cell dysfunction is therefore key to understanding the aging process. Here, using a model carrying a proofreading-defective mitochondrial DNA polymerase, we demonstrate hematopoietic defects reminiscent of premature HSC aging, including anemia, lymphopenia, and myeloid lineage skewing. However, in contrast to physiological stem cell aging, rapidly accumulating mitochondrial DNA mutations had little functional effect on the hematopoietic stem cell pool, and instead caused distinct differentiation blocks and/or disappearance of downstream progenitors. These results show that intact mitochondrial function is required for appropriate multilineage stem cell differentiation, but argue against mitochondrial DNA mutations per se being a primary driver of somatic stem cell aging.

  • 35.
    Nygren, Jens M.
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Lindberg, Susanne
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Wärnestål, Pontus
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsa och omvårdnad.
    Involving Children With Cancer in Health Promotive Research: A Case Study Describing Why, What, and How2017Inngår i: JMIR Research Protocols, ISSN 1929-0748, E-ISSN 1929-0748, Vol. 6, nr 2, artikkel-id e19Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Participatory research approaches have been introduced to meet end-users’ needs in the development of health promotion interventions among children. However, whereas children are increasingly involved as passive informants in particular parts of research, they are rarely involved as partners, equal to adult researchers, throughout the research process. This is especially prominent in the context of child health where the child is commonly considered to be vulnerable or when the research concerns sensitive situations. In these cases, researchers and gatekeepers to children’s involvement base their resistance to active involvement of children on potential adverse effects on the accuracy or quality of the research or on ethical or moral principles that participation might harm the child. Thus most research aimed at developing health promotion interventions for children in health care is primarily based on the involvement of parents, caregivers, and other stakeholders.

    Objective: The objective of this paper is to discuss reasons for involving children in health promotive research and to explore models for children’s participation in research as a basis for describing how researchers can use design methodology and participatory approaches to support the participation and contribution of children in a vulnerable context.

    Methods: We developed and applied a model for children's participation in research to the development of a digital peer support service for children cancer survivors. This guided the selection of appropriate research and design methodologies (such as interviews, focus groups, design sessions, and usability evaluation) for involving the children cancer survivors (8-12 years) in the design of a digital peer support service.

    Results: We present a model for what children’s participation in research means and describe how we practically implemented this model in a research project on children with cancer. This paper can inform researchers in their planning of strategies for children’s participation and ensure future development of health promotion interventions for children is based on their perspectives.

    Conclusions: Challenges in reaching a suitable degree of participation during a research project involve both creating opportunities for children to have genuine influence on the research process and organizing this involvement so that they feel they understand what they are involved in and why. To achieve this, it is essential to enable children to be involved in research over time to gain confidence in the researchers and to develop children’s abilities to make decisions throughout the research processes.

  • 36.
    Nygren, Jens M.
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Zukauskaite, Elena
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Westberg, Niklas
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    User-participation in Coproduction of Health Innovation2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Background: This project concerns advancing knowledge, methods and logics for user-participation in coproduction of health innovations. Such advancement is vital for several reasons. From a user perspective, participation in coproduction provides an opportunity to gain real influence over goal definition, design and implementation of health innovations, ensuring that the solution developed solves real problems in right ways. From a societal perspective, it’s amean to improve the efficiency of healthcare and the implementation of the Patient Act. As for industry, frameworks and knowledge of coproduction offers tools to operate in a complex sector, with great potential for innovation of services and products.

    Objectives: The fundamental objective of this project is to advance knowledge and methods of how user- participation in the coproduction of health innovations can be applied in order to benefit users, industry and public sector.

    Method: This project is a synergy project, which means that the objective will be accomplished through collaboration and meta-analysis between three sub-projects that address different user groups, apply different strategies to promote human health and relate to different parts of the health sector. The work on the work packages will use case methodology for data collection and analysis based on the subprojects as data sources. More concretely, a logic of a multiple case studies will be applied with each subproject representing a separate case which is similar to each other in its attention to user-participation in coproduction, but different regarding e.g. context and target groups. At the synergy level the framework methodology will be used to handle and analyse the vast amount of information generated within the subprojects.

    Results and conclusions: By addressing the objective of this project, we will create new knowledge on how to manage challenges to health innovation associated with the coproduction process, the positioning of solutions and realisation.

  • 37.
    Nygren, Jens Martin
    et al.
    Lund University, Lund, Sweden.
    Bryder, David
    Lund University, Department of Experimental Medical Science, Sweden.
    A novel assay to trace proliferation history in vivo reveals that enhanced divisional kinetics accompany loss of hematopoietic stem cell self-renewal2008Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 3, nr 11, s. art. no. e3710-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The maintenance of lifelong blood cell production ultimately rests on rare hematopoietic stem cells (HSCs) that reside in the bone marrow microenvironment. HSCs are traditionally viewed as mitotically quiescent relative to their committed progeny. However, traditional techniques for assessing proliferation activity in vivo, such as measurement of BrdU uptake, are incompatible with preservation of cellular viability. Previous studies of HSC proliferation kinetics in vivo have therefore precluded direct functional evaluation of multi-potency and self-renewal, the hallmark properties of HSCs. METHODOLOGY/PRINCIPAL FINDINGS: We developed a non-invasive labeling technique that allowed us to identify and isolate candidate HSCs and early hematopoietic progenitor cells based on their differential in vivo proliferation kinetics. Such cells were functionally evaluated for their abilities to multi-lineage reconstitute myeloablated hosts. CONCLUSIONS: Although at least a few HSC divisions per se did not influence HSC function, enhanced kinetics of divisional activity in steady state preceded the phenotypic changes that accompanied loss of HSC self-renewal. Therefore, mitotic quiescence of HSCs, relative to their committed progeny, is key to maintain the unique functional and molecular properties of HSCs.

  • 38.
    Nygren, Jens Martin
    et al.
    Lund University.
    Bryder, David
    Lund University.
    Implications of Developmental Switches for Hematopoietic Stem Cell Aging2009Inngår i: Handbook on Immunosenescence: Basic Understanding and Clinical Applications / [ed] Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa and Graham Pawelec, Dordrecht: Springer Science+Business Media B.V., 2009, s. 589-611Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    Each of the different hematopoietic cell types has their own properties and function, but only when they all act in tight synergy are they able to constitute a highly specific and efficient immune defense capable of efficient protection from invading pathogens and appropriate maintenance of blood clotting and oxygen transport functions. All blood cell types are continuously produced in the bone-marrow by rare hematopoietic stem cells that persist throughout the life of the organism. These stem cells are influenced by their environment and developmental history and experience a range of cell intrinsic changes that over time alter their functional properties. These timed changes include alterations in fundamental processes such as self-renewal, proliferation, differentiation and gene expression, thereby being crucial for both normal maturation as well as hematopoietic aging.

  • 39.
    Nygren, Jens Martin
    et al.
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Bryder, David
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Jacobsen, Sten Eirik W
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property2006Inngår i: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 177, nr 1, s. 201-208Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Adult mouse hemopoietic stem cells (HSCs) are typically quiescent and enter and progress through the cell cycle rarely in steady-state bone marrow, but their rate of proliferation can be dramatically enhanced on demand. We have studied the cell cycle kinetics of HSCs in the developing fetal liver at a stage when they expand extensively. Despite that 100% of fetal liver HSCs divide within a 48-h period, their average cell cycle transit time (10.6 h) is twice that of their downstream progenitors, translating into a prolonged G(1) transit and a period of relative quiescence (G(0)). In agreement with their prolonged G(1) transit when compared with hemopoietic progenitors, competitive transplantation experiments demonstrate that fetal HSCs are highly enriched in G(1) but also functional in S-G(2)-M. This observation combined with experimental data demonstrating that adult HSCs forced to expand ex vivo also sustain a uniquely prolonged cell cycle and G(1) transit, demonstrate at least in part why purified HSCs at any state of development or condition are highly enriched in the G(0)-G(1) phases of the cell cycle. We propose that a uniquely prolonged cell cycle transit is a defining stem cell property, likely to be critical for their maintenance and self-renewal throughout development.

  • 40.
    Nygren, Jens Martin
    et al.
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Jovinge, Stefan
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Breitbach, Martin
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Säwén, Petter
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Röll, Wilhelm
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Hescheler, Jürgen
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Taneera, Jalal
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Fleischmann, Bernd K
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Jacobsen, Sten Eirik W
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation2004Inngår i: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 10, nr 5, s. 494-501Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Recent studies have suggested that bone marrow cells might possess a much broader differentiation potential than previously appreciated. In most cases, the reported efficiency of such plasticity has been rather low and, at least in some instances, is a consequence of cell fusion. After myocardial infarction, however, bone marrow cells have been suggested to extensively regenerate cardiomyocytes through transdifferentiation. Although bone marrow-derived cells are already being used in clinical trials, the exact identity, longevity and fate of these cells in infarcted myocardium have yet to be investigated in detail. Here we use various approaches to induce acute myocardial injury and deliver transgenically marked bone marrow cells to the injured myocardium. We show that unfractionated bone marrow cells and a purified population of hematopoietic stem and progenitor cells efficiently engraft within the infarcted myocardium. Engraftment was transient, however, and hematopoietic in nature. In contrast, bone marrow-derived cardiomyocytes were observed outside the infarcted myocardium at a low frequency and were derived exclusively through cell fusion.

  • 41.
    Nygren, Jens Martin
    et al.
    Lund University, Sweden.
    Liuba, Karina
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Breitbach, Martin
    Institute of Physiology I, Life & Brain Center, University of Bonn, Germany.
    Stott, Simon
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Thorén, Lina
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Roell, Wilhelm
    Department of Cardiac Surgery, University of Bonn, Germany.
    Geisen, Caroline
    Institute of Physiology I, Life & Brain Center, University of Bonn, Germany.
    Sasse, Philipp
    Institute of Physiology I, Life & Brain Center, University of Bonn, Germany.
    Kirik, Deniz
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Björklund, Anders
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Nerlov, Claus
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Fleischmann, Bernd K
    Institute of Physiology I, Life & Brain Center, University of Bonn, Germany.
    Jovinge, Stefan
    2Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Jacobsen, Sten Eirik W
    2Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
    Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion2008Inngår i: Nature Cell Biology, ISSN 1465-7392, E-ISSN 1476-4679, Vol. 10, nr 5, s. 584-92Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation.

  • 42.
    Nygren, Jens Martin
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Stigmar, Jennie
    Lund University Hospital, Lund, Sweden.
    Young adult cancer survivor’s experiences of psychosocial rehabilitation2012Inngår i: NOPHO NOBOS Meeting and Congress Uppsala, Sweden, May 19 – 22, 2012: Programme and abstract book, 2012, s. 110-110Konferansepaper (Fagfellevurdert)
  • 43.
    Nygren, Jens Martin
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Zukauskaite, Elena
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Westberg, Niklas
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    User Participation in Coproduction of Health Innovation: Proposal for a Synergy Project2018Inngår i: JMIR Research Protocols, ISSN 1929-0748, E-ISSN 1929-0748, Vol. 7, nr 5, artikkel-id e126Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: This project concerns advancing knowledge, methods, and logic for user participation in coproduction of health innovations. Such advancement is vital for several reasons. From a user perspective, participation in coproduction provides an opportunity to gain real influence over goal definition, design, and implementation of health innovations, ensuring that the solution developed solves real problems in right ways. From a societal perspective, it's a mean to improve the efficiency of health care and the implementation of the Patient Act. As for industry, frameworks and knowledge of coproduction offer tools to operate in a complex sector, with great potential for innovation of services and products.

    Objective: The fundamental objective of this project is to advance knowledge and methods of how user participation in the coproduction of health innovations can be applied in order to benefit users, industry, and public sector.

    Methods: This project is a synergy project, which means that the objective will be accomplished through collaboration and meta-analysis between three subprojects that address different user groups, apply different strategies to promote human health, and relate to different parts of the health sector. Furthermore, subprojects focus on distinctive stages in the spectrum of innovation, with the objective to generate knowledge of the innovation process as a whole. The project is organized around three work packages related to three challenges-coproduction, positioning, and realization. Each subproject is designed such that it has its own field of study with clearly identified objectives but also targets work packages to contribute to the project as a whole. The work on the work packages will use case methodology for data collection and analysis based on the subprojects as data sources. More concretely, logic of multiple case studies will be applied with each subproject representing a separate case which is similar to each other in its attention to user participation in coproduction, but different regarding, for example, context and target groups. At the synergy level, the framework methodology will be used to handle and analyze the vast amount of information generated within the subprojects.

    Results: The project period is from July 1, 2018 to June 30, 2022.

    Conclusions: By addressing the objective of this project, we will create new knowledge on how to manage challenges to health innovation associated with the coproduction process, the positioning of solutions, and realization. © Jens Nygren, Elena Zukauskaite, Niklas Westberg.

  • 44.
    Persson, Paula
    et al.
    Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmö, Sweden.
    Manetopoulos, Christina
    Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmö, Sweden.
    Lagergren, Anna
    Department for Stem Cell Biology, Lund University, Lund, Sweden.
    Nygren, Jens Martin
    Department for Stem Cell Biology, Lund University, Lund, Sweden.
    Gisler, Ramiro
    Department for Stem Cell Biology, Lund University, Lund, Sweden.
    Axelson, Håkan
    Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmö, Sweden.
    Sigvardsson, Mikael
    Department for Stem Cell Biology, Lund University, Lund, Sweden.
    Olf/EBF proteins are expressed in neuroblastoma cells: potential regulators of the Chromogranin A and SCG10 promoters2004Inngår i: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 110, nr 1, s. 22-30Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The childhood malignancy neuroblastoma is derived from developmentally arrested sympathetic nervous system precursor cells. To obtain further insight into the molecular processes involved in the formation of these tumors, we decided to investigate the functional role of Olf/EBF (O/E) transcription factors in human neuroblastoma cells. We here report that O/E-1 and O/E-2 are expressed at variable levels in neuroblastoma cell lines and that O/E proteins could be identified by electrophoretic mobility shift assays. To identify potential neuronal target genes for O/E proteins in neuroblastoma cells we investigated the ability of a set of neuronal promoters to interact with O/E-1 in electrophoretic mobility shift assays. This analysis suggested that the Chromogranin A (CgA) and SCG10 promoters both contained binding sites for O/E-1. O/E-1 was able to activate the CgA promoter in vivo and mutation of the O/E-1 binding site in the CgA promoter reduced the functional activity of the element to about 60% of the wild-type in neuroblastoma cells, supporting the idea that O/E proteins may be involved in the control of the CgA promoter. Furthermore, overexpression of O/E-1 in hippocampal progenitor cells led to neurite outgrowth, indicative of a role for O/E proteins in neuronal differentiation.

  • 45.
    Persson, Sofia
    et al.
    Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Svedberg, Petra
    Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Nygren, Jens Martin
    Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Halmstadprojektet: Kartläggning, samverkan och analys för utveckling av en deltagarstyrd intervention för att främja barns psykiska hälsa2014Rapport (Annet vitenskapelig)
  • 46.
    Poljakovic, Mirjana
    et al.
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden.
    Nygren, Jens Martin
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden.
    Persson, Katarina
    Department of Clinical Pharmacology, Lund University Hospital, SE-221 85, Lund, Sweden.
    Signalling pathways regulating inducible nitric oxide synthase expression in human kidney epithelial cells2003Inngår i: European Journal of Pharmacology, ISSN 0014-2999, E-ISSN 1879-0712, Vol. 469, nr 1-3, s. 21-28Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The purpose of this study was to elucidate the signalling pathways involved in the cytokine-activated inducible nitric oxide synthase (iNOS) response in a human kidney epithelial cell line, A498. Unstimulated cells did not express iNOS. Exposure of A498 cells to a cytokine mixture consisting of interferon gamma, interleukin-1 beta and tumor necrosis factor-alpha (TNF-alpha) increased nitrite production, iNOS mRNA and protein expression. Pharmacological inhibition of tyrosine kinases, including janus kinase (JAK2), and protein kinase C (PKC) inhibited cytokine-mediated nitrite production and iNOS protein expression. The involvement of mitogen-activated protein kinases (MAPKs) was investigated. Inhibition of p38 MAPK, but not of an upstream activator of extracellular signal-regulated kinase (ERK), caused a decrease in iNOS expression and nitrite production in response to cytokines. Electrophoretic mobility shift assay of nuclear extract from cytokine-stimulated cells demonstrated a pronounced binding to a nuclear factor kappa B (NF-kappa B) sequence present in the human iNOS promoter. Furthermore, the NF-kappa B inhibitor pyrrolidinedithiocarbamate (PDTC) decreased cytokine-activated iNOS protein expression and nitrite production. The present study has demonstrated that cytokine-stimulated iNOS expression in human kidney epithelial cells involves activation of tyrosine kinases, including JAK2, PKC, p38 MAPK and NF-kappa B.

  • 47.
    Rögnvaldsson, Thorsteinn
    et al.
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Brink, Joachim
    Högskolan i Halmstad.
    Florén, Henrik
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Centrum för innovations-, entreprenörskaps- och lärandeforskning (CIEL).
    Gaspes, Veronica
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Holmgren, Noél
    University of Skövde, Skövde, Sweden.
    Lutz, Mareike
    Högskolan i Halmstad.
    Nilsson, Pernilla
    Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, Forskning om utbildning och lärande inom lärarutbildningen (FULL).
    Olsfelt, Jonas
    Högskolan i Halmstad.
    Svensson, Bertil
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Ericsson, Claes
    Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, Forskning om utbildning och lärande inom lärarutbildningen (FULL).
    Gustafsson, Linnea
    Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, Kontext & kulturgränser (KK).
    Hoveskog, Maya
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Centrum för innovations-, entreprenörskaps- och lärandeforskning (CIEL).
    Hylander, Jonny
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Bio- och miljösystemforskning (BLESS).
    Jonsson, Magnus
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Rosén, Bengt-Göran
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Maskinteknisk produktframtagning (MTEK).
    Sandberg, Mikael
    Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, Centrum för samhällsanalys (CESAM).
    Benner, Mats
    Lund University, Lund, Sweden.
    Berg, Martin
    Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, Centrum för samhällsanalys (CESAM).
    Bergvall, Patrik
    Högskolan i Halmstad.
    Carlborg, Anna
    Högskolan i Halmstad.
    Fleischer, Siegfried
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Bio- och miljösystemforskning (BLESS).
    Hållander, Magnus
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Mattsson, Marie
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Bio- och miljösystemforskning (BLESS).
    Olsson, Charlotte
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Bio- och miljösystemforskning (BLESS).
    Pettersson, Håkan
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS).
    Rundquist, Jonas
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Centrum för innovations-, entreprenörskaps- och lärandeforskning (CIEL).
    Sahlén, Göran
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Bio- och miljösystemforskning (BLESS).
    Waara, Sylvia
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Bio- och miljösystemforskning (BLESS).
    Weisner, Stefan
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Bio- och miljösystemforskning (BLESS).
    Werner, Sven
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Bio- och miljösystemforskning (BLESS).
    ARC13 – Assessment of Research and Coproduction: Reports from the assessment of all research at Halmstad University 20132014Rapport (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    During 2013, an evaluation of all the research conducted at Halmstad University was carried out. The purpose was to assess the quality of the research, coproduction, and collaboration in research, as well as the impact of the research. The evaluation was dubbed the Assessment of Research and Coproduction 2013, or ARC13. (Extract from Executive Summary)

  • 48.
    Sitnicka, Ewa
    et al.
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Buza-Vidas, Natalija
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Ahlenius, Henrik
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Cilio, Corrado M.
    Department of Clinical Sciences, Cellular Autoimmunity Unit, Malmö University Hospital, Malmö, Sweden.
    Gekas, Christos
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Nygren, Jens Martin
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Månsson, Robert
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Cheng, Min
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Jensen, Christina T.
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Svensson, Marcus
    Immunology Section, Department of Cell and Molecular Biology, Lund University, Lund, Sweden.
    Leandersson, Karin
    Experimental Pathology, Malmö University Hospital, Malmö, Sweden.
    Agace, William W.
    Immunology Section, Department of Cell and Molecular Biology, Lund University, Lund, Sweden.
    Sigvardsson, Mikael
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Jacobsen, Sten Eirik W.
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
    Critical role of FLT3 ligand in IL-7 receptor-independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors2007Inngår i: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 110, nr 8, s. 2955-2964Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The molecular pathways regulating lymphoid priming, fate, and development of multipotent bone marrow (BM) stem/progenitor cells that continuously replace thymic progenitors remain largely unknown. Herein, we show that fms-like tyrosine kinase 3 (Flt3) ligand (Fl)-deficient mice have distinct reductions in the earliest thymic progenitors in fetal, postnatal, and adult thymus. A critical role of FL in thymopoiesis was particularly evident in the absence of interleukin-7 receptor alpha (IL-7Ralpha) signaling. Fl-/-Il-7r-/- mice have extensive reductions in fetal and postnatal thymic progenitors that result in a loss of active thymopoiesis in adult mice, demonstrating an indispensable role of FL in IL-7Ralpha-independent fetal and adult T lymphopoiesis. Moreover, we establish a unique and critical role of FL, distinct from that of IL-7Ralpha, in regulation of the earliest lineage-negative (Lin(-)) Lin(-)SCA1+KIT+ (LSK) FLT3(hi) lymphoid-primed multipotent progenitors in BM, demonstrating a key role of FLT3 signaling in regulating the very earliest stages of lymphoid progenitors.

  • 49.
    Sitnicka, Ewa
    et al.
    Hematopoietic Stem Cell Laboratory, Lund Strat. Res. Ctr. S. C. B./C. T., Lund University Hospital.
    Buza-Vidas, Natalija
    Hematopoietic Stem Cell Laboratory, Lund Strat. Res. Ctr. S. C. B./C. T., Lund University Hospital.
    Larsson, Staffan
    Hematopoietic Stem Cell Laboratory, Lund Strat. Res. Ctr. S. C. B./C. T., Lund University Hospital.
    Nygren, Jens Martin
    Hematopoietic Stem Cell Laboratory, Lund Strat. Res. Ctr. S. C. B./C. T., Lund University Hospital.
    Liuba, Karina
    Hematopoietic Stem Cell Laboratory, Lund Strat. Res. Ctr. S. C. B./C. T., Lund University Hospital.
    Jacobsen, Sten Erik W
    Hematopoietic Stem Cell Laboratory, Lund Strat. Res. Ctr. S. C. B./C. T., Lund University Hospital.
    Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: Distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells2003Inngår i: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 102, nr 3, s. 881-886Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The cytokine tyrosine kinase receptors c-kit and flt3 are expressed and function in early mouse and human hematopoiesis. Through its ability to promote ex vivo expansion and oncoretroviral transduction of primitive human hematopoietic progenitors, the flt3 ligand (FL) has emerged as a key stimulator of candidate human hematopoietic stem cells (HSCs). However, recent studies in the mouse suggest that though it is present on short-term repopulating cells, flt3 is not expressed on bone marrow long-term reconstituting HSCs, the ultimate target for the development of cell replacement and gene therapy. Herein we demonstrate that though only a fraction of human adult bone marrow and cord blood CD34+long-term culture-initiating cells (LTC-ICs) express flt3, most cord blood lymphomyeloid HSCs capable of in vivo reconstituting nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice are flt3+. The striking difference in flt3 and c-kit expression on mouse and candidate human HSCs translated into a corresponding difference in flt3 and c-kit function because FL was more efficient than SCF at supporting the survival of candidate human HSCs. In contrast, SCF is far superior to FL as a viability factor for mouse HSCs. Thus, the present data provide compelling evidence for a contrasting expression and response pattern of flt3 and c-kit on mouse and human HSCs.

  • 50.
    Sjöberg, Carina
    et al.
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI). Region Halland, Halmstad Hospital, Halmstad, Sweden.
    Amhliden, Helene
    Högskolan i Halmstad, Akademin för hälsa och välfärd. Region Halland, Halmstad Hospital, Halmstad, Sweden.
    Nygren, Jens
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Arvidsson, Susann
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    Svedberg, Petra
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI), Hälsofrämjande processer.
    The perspective of children on factors influencing their participation in perioperative care2015Inngår i: Journal of Clinical Nursing, ISSN 0962-1067, E-ISSN 1365-2702, Vol. 24, nr 19-20, s. 2945-2953Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aims and objectives

    To describe the experiences of participation in perioperative care of 8- to 11-year-old children.

    Background

    All children have the right to participate in decisions that affect them and have the right to express their views in all matters that concern them. Allowing children to be involved in their perioperative care can make a major difference in terms of their well-being by decreasing fear and anxiety and having more positive experiences. Taking the views of children into account and facilitating their participation could thus increase the quality of care.

    Design

    Descriptive qualitative design.

    Methods

    The study was conducted in 2013 and data were collected by narrative interviews with 10 children with experience from perioperative care in Sweden. Qualitative content analysis was chosen to describe the variations, differences and similarities in children's experiences of participation in perioperative care.

    Results

    The result showed that receiving preparatory information, lack of information regarding postoperative care and wanting to have detailed information are important factors for influencing children's participation. Interaction with healthcare professionals, in terms of being listened to, being a part of the decision-making and feeling trust, is important for children's participation in the decision-making process. Poor adaptation of the care environment to the children's needs, feeling uncomfortable while waiting and needs for distraction are examples of how the environment and the care in the operating theatre influence the children's experiences of participation.

    Conclusions

    Efforts should be made to improve children's opportunities for participation in the context of perioperative care and further research is needed to establish international standards for information strategies and care environment that promotes children's participation in perioperative care.

    Relevance to clinical practice

    Nurse anaesthetists need to acquire knowledge and develop strategies for providing preparatory visits and information to children prior to surgery as well as reducing waiting times and creating environments with meaningful and tailored opportunities for distraction in perioperative care. © 2015 John Wiley & Sons Ltd.

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