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  • 1.
    Johannesson, Ulrika
    et al.
    Division of Obstetrics and Gynecology, Department of Clinical Sciences, Danderyd Hospital, Stockholm.
    Sahlin, Lena
    Division of Reproductive Endocrinology, Department of Woman and Child Health, Karolinska Institutet, Stockholm.
    Masironi, Britt
    Division of Reproductive Endocrinology, Department of Woman and Child Health, Karolinska Institutet, Stockholm.
    Hilliges, Marita
    Högskolan i Halmstad, Sektionen för ekonomi och teknik (SET), Bio- och miljösystemforskning (BLESS), Biomekanik och biomedicin.
    Blomgren, Bo
    AstraZeneca Safety Assessment, Södertälje.
    Rylander, Eva
    Division of Obstetrics and Gynecology, Department of Clinical Sciences, Danderyd Hospital, Stockholm.
    Bohm-Starke, Nina
    Division of Obstetrics and Gynecology, Department of Clinical Sciences, Danderyd Hospital, Stockholm.
    Steroid receptor expression and morphology in provoked vestibulodynia2008Inngår i: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 198, nr 3, s. 311.e1-311.e6Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: This study was undertaken to survey the steroid receptor expression and morphology in the vulvar vestibular mucosa in women with provoked vestibulodynia.

    Study Design: Fourteen patients and 25 controls without oral contraceptives were included. Vestibular biopsy specimens were obtained and analyzed by using immunohistochemistry, followed by computerized image analysis of estrogen receptors greek small letter alpha and β, progesterone receptors A and B, glucocorticoid receptor, androgen receptor, and the proliferation marker Ki67. The morphology was estimated by measuring 4 parameters in the epithelium.

    Results: There was a significantly higher expression of estrogen receptor greek small letter alpha in both the epithelium (P = .04) and the stroma (P = .02) in the patient specimens compared with the controls. There were no significant differences in the other analyses performed.

    Conclusion: There is an increased expression of estrogen receptor greek small letter alpha in the vestibular mucosa but the epithelial morphology seems unaffected in women with provoked vestibulodynia. Further studies regarding plausible associations to neurogenic inflammation are needed.

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