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  • 1.
    Nygren, Jens Martin
    et al.
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Jovinge, Stefan
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Breitbach, Martin
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Säwén, Petter
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Röll, Wilhelm
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Hescheler, Jürgen
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Taneera, Jalal
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Fleischmann, Bernd K
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Jacobsen, Sten Eirik W
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
    Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation2004In: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 10, no 5, p. 494-501Article in journal (Refereed)
    Abstract [en]

    Recent studies have suggested that bone marrow cells might possess a much broader differentiation potential than previously appreciated. In most cases, the reported efficiency of such plasticity has been rather low and, at least in some instances, is a consequence of cell fusion. After myocardial infarction, however, bone marrow cells have been suggested to extensively regenerate cardiomyocytes through transdifferentiation. Although bone marrow-derived cells are already being used in clinical trials, the exact identity, longevity and fate of these cells in infarcted myocardium have yet to be investigated in detail. Here we use various approaches to induce acute myocardial injury and deliver transgenically marked bone marrow cells to the injured myocardium. We show that unfractionated bone marrow cells and a purified population of hematopoietic stem and progenitor cells efficiently engraft within the infarcted myocardium. Engraftment was transient, however, and hematopoietic in nature. In contrast, bone marrow-derived cardiomyocytes were observed outside the infarcted myocardium at a low frequency and were derived exclusively through cell fusion.

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