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Improved Muscle Mitochondrial Capacity Following Gastric Bypass Surgery in Obese Subjects
Department of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Solna, Stockholm, Sweden.
Bariatric Center, Sophiahemmet, Stockholm, Sweden.
Department of Anaesthesiology and Intensive Care, Karolinska Institutet, Huddinge, Stockholm, Sweden.
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2016 (English)In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 26, no 7, 1391-1397 p.Article in journal (Refereed) Published
Abstract [en]

Background

Weight loss resulting from low-calorie diets is often less than expected. We hypothesized that energy restriction would influence proton leakage and improve mitochondrial efficiency, leading to reduced energy expenditure, partly explaining the difficulties in weight loss maintenance.

Methods

Eleven women with a median BMI of 38.5 kg/m2 (q-range 37–40), and referred to gastric bypass surgery participated. Before surgery, and at 6 months of follow-up, muscle biopsies were collected from the vastus lateralis muscle. Mitochondria were isolated and analyzed for coupled (state 3) and uncoupled (state 4) respiration and mitochondrial capacity (P/O ratio).

Results

At follow-up, the participants had a median BMI of 29.6 kg/m2 (28.3–32.0). State 3 increased from 20.6 (17.9–28.9) to 34.9 nmol O2/min/U citrate synthase (CS) (27.0–49.0), p = 0.01, while state 4 increased from 2.8 (1.8–4.2) to 4.2 nmol O2/min/U CS (3.1–6.1), although not statistically significant. The P/O ratio increased from 2.7 (2.5–2.8) to 3.2 (3.0–3.4), p = 0.02, indicating improved mitochondrial efficiency.

Conclusions

Six months after gastric bypass surgery, the mitochondrial capacity for coupled, i.e., ATP-generating, respiration increased, and the P/O ratio improved. Uncoupled respiration was not enhanced to the same extent. This could partly explain the decreased basal metabolism and the reduced inclination for weight loss during energy restriction. © Springer Science+Business Media New York 2015

Place, publisher, year, edition, pages
New York, NY: Springer, 2016. Vol. 26, no 7, 1391-1397 p.
Keyword [en]
Energy metabolism, Mitochondria, Muscle, Obesity, Thermogenesis, Weight loss
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:hh:diva-29648DOI: 10.1007/s11695-015-1932-zISI: 000377939200005PubMedID: 26471784Scopus ID: 2-s2.0-84944705891OAI: oai:DiVA.org:hh-29648DiVA: diva2:861957
Funder
Swedish Research Council, 14244
Note

Financial support was provided through grants from the Swedish Transport Administration, the Swedish Nutrition Foundation, the Swedish Research Council (no: 14244), Stiftelsen Serafimerlasarettet, and the regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet. The pedometers were generously provided by Abbott Scandinavia AB.

Available from: 2015-10-19 Created: 2015-10-19 Last updated: 2016-07-18Bibliographically approved

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Svensson, MadeleineLagerros, Ylva Trolle

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