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The risk for depression in patients with ankylosing spondylitis: a population-based cohort study
Epidemiology and Register Centre South Skåne, Skåne University Hospital, Lund, Sweden & Department of Orthopaedics, Leiden University Medical Centre, Leiden, the Netherlands.
Halmstad University, School of Business, Engineering and Science, Biological and Environmental Systems (BLESS), Biomechanics and Biomedicine. Department of Clinical Sciences, Lund, Section of Rheumatology, Lund University, Lund, Sweden & Spenshult, Research and Development Center, Oskarström, Sweden.ORCID iD: 0000-0002-8081-579X
Department of Clinical Sciences, Lund, Section of Rheumatology, Lund University, Lund, Sweden & Spenshult, Research and Development Center, Oskarström, Sweden.ORCID iD: 0000-0002-6294-538X
Epidemiology and Register Centre South Skåne, Skåne University Hospital, Lund, Sweden; Department of Clinical Sciences, Lund, Section of Rheumatology, Lund University, Lund, Sweden & Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden.
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2014 (English)In: Arthritis Research & Therapy, ISSN 1478-6354, E-ISSN 1478-6362, Vol. 16, no 5, 418Article in journal (Refereed) Published
Abstract [en]

Introduction: Depression is frequent in ankylosing spondylitis (AS) patients. However, epidemiological data about the potential increase in risk are lacking. This study compares the rate of doctor-diagnosed depression in a well defined cohort of AS patients to the general population seeking care.

Methods: The Skåne Healthcare Register comprises healthcare data of each resident in Region Skåne, Sweden (population 1.2 million), including ICD-10 diagnoses. Using physician coded consultation data from years 1999 to 2011, we calculated depression consultation rates for all AS patients. We obtained standardized depression-rate ratios by dividing the observed depression rate in AS patients by the expected rate based on the corresponding age- and sex-specific rates of depression in the general population seeking care. A ratio >1 equals a higher rate of depression among AS patients.

Results: The AS cohort consisted of 1738 subjects (65% men) with a mean age of 54 years. The reference population consisted of 967,012 subjects. During the 13-year observation period 10% (n = 172) of the AS cohort had a doctor-diagnosed depression compared to 6% (n = 105) to be expected. The standardized estimate of depression-rate ratio was 1.81 (95% confidence interval 1.44 to 2.24) in women men and 1.49 (1.20 to 1.89) in men.

Conclusions: The rate of doctor-diagnosed depression is increased about 80% in female and 50% in male AS patients. Future challenges are to timely identify and treat the AS patients who suffer from depression. © 2014 Meesters et al.; licensee BioMed Central Ltd.

Place, publisher, year, edition, pages
London: BioMed Central, 2014. Vol. 16, no 5, 418
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hh:diva-27285DOI: 10.1186/s13075-014-0418-zISI: 000349885900003PubMedID: 25209603Scopus ID: 2-s2.0-84910037660OAI: oai:DiVA.org:hh-27285DiVA: diva2:772023
Funder
Swedish Research Council
Note

The authors acknowledge funding support from Swedish Research Council, Medical Faculty Lund University, and Region Skåne.

Available from: 2014-12-15 Created: 2014-12-15 Last updated: 2017-03-17Bibliographically approved

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CiteExportLink to record
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