In this chapter we examine how institutional factors in and around university incubators are associated with the likelihood that a female will engage in the commercialization of university science by championing an incubator project. Our empirical data comes from a unique database consisting of over 1400 venture projects in 19 Swedish incubators that are part of a nationally financed incubator program. Our findings suggest that women’s engagement in academic entrepreneurship is related to a number of institutional factors operating at multiple levels in and around incubators. We find systematic differences related to 1) the proportion of female faculty in senior positions at the associated university, 2) the presence of women on incubator boards; and 3) the technological sector of the project itself. In all, our findings largely support the notion that university incubators can be seen as embedded in gendered structures, where socially and culturally constructed roles and relationships between men and women create imbalances in their prospective career opportunities.