Healthcare organizations are subject to an increasing complexity in the management of patient information. The modern healthcare system is developed through projects in large scale. The complexity is rapidly increasing and lack of coordination between projects is crucial in relation to performance. The contemporary approach following the traditional project related approach is insufficient and obsolete and the underlying interconnectivity between elements in a multi-project environment can be used to explore new compositions of projects, programs and portfolios. By a systematic approach in managing interdependencies based on exploring the flow of information between projects on three different levels two major outcomes can be concluded. In our systematic DSM/DMM approach we explore how projects can be organized in programs and in portfolios.