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Skeletal muscle fatty acid transporter protein expression in type 2 diabetes patients compared with overweight, sedentary men and age-matched, endurance-trained cyclists
Department of Movement Sciences, Maastricht University, Maastricht, Netherlands & Department of Movement Sciences, Maastricht University, Maastricht, Netherlands.
Institute of Clinical Research, University of Nottingham Medical School, Nottingham, United Kingdom.
Department of Human Biology, Maastricht University, Maastricht, Netherlands.ORCID iD: 0000-0003-4235-0634
Institute of Clinical Research, University of Nottingham Medical School, Nottingham, United Kingdom.
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2007 (English)In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 190, no 3, 209-219 p.Article in journal (Refereed) Published
Abstract [en]

AIM: Membrane fatty acid transporters can modulate the balance between fatty acid uptake and subsequent storage and/or oxidation in muscle tissue. As such, skeletal muscle fatty acid transporter protein expression could play an important role in the etiology of insulin resistance and/or type 2 diabetes.

METHODS: In the present study, fatty acid translocase (FAT/CD36), plasma membrane-bound fatty acid-binding protein (FABPpm) and fatty acid transport protein 1 (FATP1) mRNA and protein expression were assessed in muscle tissue obtained from 10 sedentary, overweight type 2 diabetes patients (60 +/- 2 years), 10 sedentary, weight-matched normoglycemic controls (60 +/- 2 years) and 10 age-matched, endurance trained cyclists (57 +/- 1 years).

RESULTS: Both FAT/CD36 and FATP1 mRNA and protein expression did not differ between groups. In contrast, FABPpm mRNA and protein expression were approx. 30-40% higher in the trained men compared with the diabetes patients (P < 0.01) and sedentary controls (P < 0.05).

CONCLUSIONS: Skeletal muscle FAT/CD36, FABPpm and FATP1 mRNA and protein expression are not up- or downregulated in a sedentary and/or insulin resistant state. In contrast, FABPpm expression is upregulated in the endurance trained state and likely instrumental to allow greater fatty acid oxidation rates. © 2007 The Authors.

Place, publisher, year, edition, pages
Chichester: Wiley-Blackwell, 2007. Vol. 190, no 3, 209-219 p.
Keyword [en]
CD36, exercise, FABPpm, FATP1, GLUT4, metabolism, muscle
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hh:diva-26618DOI: 10.1111/j.1748-1716.2007.01698.xISI: 000247318600004PubMedID: 17394567Scopus ID: 2-s2.0-34250689989OAI: oai:DiVA.org:hh-26618DiVA: diva2:750419
Note

This study was supported by the Netherlands Heart Foundation (grant 2002.T049) and the European Commission (Integrated Project LSHM-CT-2004-005272, Exgenesis).

Available from: 2014-09-29 Created: 2014-09-29 Last updated: 2015-09-29Bibliographically approved

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