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Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects
Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
Sunnaas Hospital, Nesoddtangen, Norway.
Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0003-4235-0634
Sunnaas Hospital, Nesoddtangen, Norway.
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2011 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 110, no 5, p. 1204-1210Article in journal (Refereed) Published
Abstract [en]

Skeletal muscle plays an important role in the regulation of energy homeostasis; therefore, the ability of skeletal muscle to adapt and alter metabolic gene expression in response to changes in physiological demands is critical for energy balance. Individuals with cervical spinal cord lesions are characterized by tetraplegia, impaired thermoregulation, and altered skeletal muscle morphology. We characterized skeletal muscle metabolic gene expression patterns, as well as protein content, in these individuals to assess the impact of spinal cord injury on critical determinants of skeletal muscle metabolism. Our results demonstrate that mRNA levels and protein expression of skeletal muscle genes essential for glucose storage are reduced, whereas expression of glycolytic genes is reciprocally increased in individuals with spinal cord injury. Furthermore, expression of genes essential for lipid oxidation is coordinately reduced in spinal cord injured subjects, consistent with a marked reduction of mitochondrial proteins. Thus spinal cord injury resulted in a profound and tightly coordinated change in skeletal muscle metabolic gene expression program that is associated with the aberrant metabolic features of the tissue. © 2011 the American Physiological Society.

Place, publisher, year, edition, pages
Bethesda, MD: American Physiological Society , 2011. Vol. 110, no 5, p. 1204-1210
Keyword [en]
glycogen storage, metabolism, oxidation, physical inactivity, tetraplegia
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hh:diva-26617DOI: 10.1152/japplphysiol.00686.2010ISI: 000290472400012PubMedID: 21393466Scopus ID: 2-s2.0-79956108795OAI: oai:DiVA.org:hh-26617DiVA: diva2:750417
Available from: 2014-09-29 Created: 2014-09-29 Last updated: 2017-12-05Bibliographically approved

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