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Depression is More Common in Patients with Ankylosing Spondylitis as Compared to the General Population Seeking Health-Care
Epi-centre Skåne, Skåne University Hospital, Lund, Sweden & Department of Orthopaedics, Rehabilitation and Physical Therapy, LUMC, Leiden, Netherlands.
Research and Development Center, Spenshult Hospital for Rheumatic Diseases, Oskarström, Sweden.ORCID iD: 0000-0002-8081-579X
Epi-centre Skåne, Skåne University Hospital, Lund, Sweden & Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden.
Research and Development Center, Spenshult Hospital for Rheumatic Diseases, Oskarström, Sweden.ORCID iD: 0000-0002-6294-538X
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2013 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 72, no Suppl. 3, A556-A556 p.Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Background: Ankylosing spondylitis (AS) affects physical function and health related quality of life. Depression has been reported to be frequent in AS patients. However, available epidemiological data are limited and estimates of the potentially increase in risk are lacking.

Objectives: To compare the rate of doctor-diagnosed depression in a well-defined cohort of AS patients to the general health-care seeking population.

Methods: The Skåne Health Care Register comprises data from each single health care consultation in the Skåne County, Sweden (population 1.2 million). Data include information about date of consultation and all ICD-10 diagnoses. Linking this register to the Swedish population register adds data regarding death and residency. We studied all patients who were registered with an AS diagnosis (ICD-10 code M45) at least once during 4 calendar years (2004 to 2007). To obtain depression rates we calculated the person-time from the day after the first occurrence of the AS diagnosis within the study period until the day of diagnosis of depression (F32 or F33) or another censoring event (death/relocation). We then obtained standardized depression-rate ratios by dividing the observed depression rate in AS patients by the expected rate based on the corresponding age- and sex specific rates of doctor-diagnosed depression in the general population of the county seeking care (reference population). A ratio >1 equals a higher rate of depression among AS patients than in the reference population of corresponding age and sex distribution.

Results: We identified 935 AS patients, 67.2% men, mean age (SD) 52.3 (14.8) years. The reference population consisted of 761,210 subjects. During the 4-year observation period 10% (n=94) of the AS cohort had a doctor-diagnosed depression compared to 7% (n=66) to be expected based on data from the reference population. The standardized depression-rate ratio in men (1.41, 95% CI 1.04–1.87) and women with AS (1.43, 95% CI 1.05–1.91) were both significantly elevated in the same order of magnitude (Table).

Conclusions: The rate of doctor-diagnosed depression was increased by about 40% in both male and female AS patients compared to the general population seeking care. Future challenges are to identify and treat the AS patients who suffer from depression as early as possible.

Place, publisher, year, edition, pages
London: BMJ Books, 2013. Vol. 72, no Suppl. 3, A556-A556 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hh:diva-25097DOI: 10.1136/annrheumdis-2013-eular.1662ISI: 000331587903427OAI: oai:DiVA.org:hh-25097DiVA: diva2:712848
Conference
EULAR 2013, Annual European Congress of Rheumatology, Madrid, Spain, 12-15 June, 2013
Available from: 2014-04-16 Created: 2014-04-16 Last updated: 2015-02-18Bibliographically approved

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CiteExportLink to record
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