Children and youth with disability in Sub-Saharan rural Africa can be seen as one of the most vulnerable groups of people in the world. The paper aims to demonstrate the importance to listen to their guardians in order to improve the situation of families with otherwise limited opportunities to get their voices heard. Based on the concept of life chances, and by carrying out 12 semi-structured interviews with guardians in Murang’a South District, Central Province, Kenya, the situation of these children and their families will be analysed. In the narratives, focussing on disability, education and future perspectives, experiences of exposure and exclusion become obvious. At the same time, the guardians express ideas on how the children’s situation and life chances could be improved. In conclusion, the relevance of practical orientated education close to their homes is highlighted. Moreover, the need for locally adapted efforts for transition into the informal labour market is emphasised.