This paper introduces the papers included in the thematic issue on Human Resource Management (HRM) and firm innovativeness in a European context. Furthermore it presents the results of a literature review on human resource management and firm innovativeness. The literature shows that the positive relationship between HRM and firm innovativeness has been confirmed. However, the explanation for how this relationship works is not equivocal/unified. Empirical studies have investigated the role of strategic HRM, specific HRM systems and HRM practices. For strategic HRM, the empirical support is still limited, while for HRM systems considerable work confirms the positive influence of commitment-based HRM. For HRM practices, in particular training, working in teams, and internal labour flexibility, including job rotation, the literature provides empirical evidence and indications that they are positively related to firm innovativeness. Copyright © 2014 Inderscience Enterprises Ltd.