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Transient isotachophoresis for sensitivity enhancement in capillary electrophoresis-mass spectrometry for peptide analysis
DMPK and Bioanalytical Chemistry, AstraZeneca R&D Mölndal, Mölndal, Sweden.
DMPK and Bioanalytical Chemistry, AstraZeneca R&D Mölndal, Mölndal, Sweden.
2000 (English)In: Electrophoresis, ISSN 0173-0835, E-ISSN 1522-2683, Vol. 21, no 14, 2859-2865 p.Article in journal (Refereed) Published
Abstract [en]

Transient isotachophoresic (ITP) focusing was used for the on-line analysis of peptides by capillary zone electrophoresis-mass spectrometry (CZE-MS), allowing injection volumes of up to 0.9 microL. A sheath liquid electrospray interface was used with a single quadrupole mass analyzer. First, the technique was applied to the qualitative analysis of a tryptic digest of cytochrome c, resulting in low-background, high-quality spectra. Second, the linear range was investigated by selected ion monitoring (SIM) for a peptidomimetic direct thrombin inhibitor melagatran (Mr 429.5) and two endogenous peptides, substance P (Mr 1348) and calcitonin gene-related peptide (alpha-CGRP; Mr 3806).

Place, publisher, year, edition, pages
Weinheim: Wiley-VCH Verlagsgesellschaft, 2000. Vol. 21, no 14, 2859-2865 p.
Keyword [en]
Isotachophoresis, Capillary electrophoresis, Mass spectrometry, Peptides
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:hh:diva-24122DOI: 10.1002/1522-2683(20000801)21:14<2859::AID-ELPS2859>3.0.CO;2-FISI: 000089275400015PubMedID: 11001295Scopus ID: 2-s2.0-0033821046OAI: oai:DiVA.org:hh-24122DiVA: diva2:679535
Available from: 2013-12-16 Created: 2013-12-09 Last updated: 2015-03-03Bibliographically approved

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CiteExportLink to record
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