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Fat intake and composition of fatty acids in serum phospholipids in a randomized, controlled, Mediterranean dietary intervention study on patients with rheumatoid arthritis
Department of Food and Nutrition, Umeå University, SE-901 87 Umeå, Sweden.
Department of Clinical Chemistry, Kalmar County Hospital, SE-391 85 Kalmar, Sweden.
Department of Medicine, Visby Hospital, SE-621 84 Visby, Sweden.
Department of Food and Nutrition, Umeå University, SE-901 87 Umeå, Sweden .ORCID iD: 0000-0002-9291-9342
2005 (English)In: Nutrition & Metabolism, ISSN 1743-7075, Vol. 2, no Article number 26Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: We have previously reported that rheumatoid arthritis patients, who adopted a modified Cretan Mediterranean diet, obtained a reduction in disease activity and an improvement in physical function and vitality. This shift in diet is likely to result in an altered intake of fatty acids. Therefore, the objective of the present study was to examine the dietary intake of fatty acids, as well as the fatty acid profile in serum phospholipids, during the dietary intervention study presented earlier. RESULTS: From baseline to the end of the study, changes in the reported consumption of various food groups were observed in the Mediterranean diet group. The change in diet resulted in a number of differences between the Mediterranean diet group and the control diet group regarding the fatty acid intake. For instance, a lower ratio of n-6 to n-3 fatty acids was observed in the Mediterranean diet group, both assessed by diet history interviews (dietary intake) and measured in serum phospholipids. Moreover, the patients in the Mediterranean diet group that showed a moderate or better clinical improvement during the study (diet responders), had a higher reported intake of n-3 fatty acids and a lower ratio of n-6 to n-3 fatty acids compared to the patients with minor or no improvement. Also the fatty acid profile in serum phospholipids differed in part between the diet responders and the diet non-responders. CONCLUSION: The changes in the fatty acid profile, indicated both by dietary assessments and through fatty acids in s-phospholipids may, at least in part, explain the beneficial effects of the Cretan Mediterranean diet that we have presented earlier.

Place, publisher, year, edition, pages
London: BioMed Central, 2005. Vol. 2, no Article number 26
Keyword [en]
adult, article, clinical trial, controlled clinical trial, controlled study, dietary intake, fat intake, female, food intake, human, interview, lipid composition, male, Mediterranean diet, phospholipid blood level, questionnaire, randomized controlled trial, rheumatoid arthritis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hh:diva-20681DOI: 10.1186/1743-7075-2-26PubMedID: 16216119Scopus ID: 2-s2.0-28444472052OAI: oai:DiVA.org:hh-20681DiVA: diva2:586322
Available from: 2013-01-11 Created: 2013-01-11 Last updated: 2014-03-05Bibliographically approved

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