Although networks have been shown in many studies to be critical for the international development of firms, surprisingly few studies have focused on the influence of local networks and global networks in the internationalisation of firms operating in industrial clusters. This study explores the internationalisation processes of small and medium sized firms operating in the medical technology cluster in the Rhone-Alp region in France. Firstly, we find that local and global networks influence the internationalisation processes of the case firms but in different ways. The influence of such networks were determined by the regional location, industry dynamics and the life-cycle of firms in the cluster. Second, internationalising firms found were Born Globals, led by entrepreneurs globally market-orientated from inception and Born Again Globals, late but rapid internationalisers. The internationalisation of Born Again Globals was triggered by a critical event that redirected the firm rapidly on to global markets late in their life-cycle. Thirdly, local networks were important for initiating internationalisation for the Born Global firm yet held limited importance for the Born Again Globals in the cluster. Local networks in the cluster were however, important for both Born Global and Born Again Globals for developing and internationalising their innovations.