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Plasma phospholipid fatty acid content is related to disease activity in ankylosing spondylitis
Division of Rheumatology, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI).ORCID iD: 0000-0002-9291-9342
Division of Clinical Nutrition and Metabolism, Department of Public Health and Caring Science, Uppsala University, Uppsala, Sweden.
Division of Clinical Nutrition and Metabolism, Department of Public Health and Caring Science, Uppsala University, Uppsala, Sweden.
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2012 (English)In: Journal of Rheumatology, ISSN 0315-162X, E-ISSN 1499-2752, Vol. 39, no 2, 327-333 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate fatty acid composition in the diet, plasma phospholipids, and adipose tissue in a cohort of patients with ankylosing spondylitis (AS), and to determine their correlations to disease activity and blood lipids in a cross-sectional study. METHODS: Diet was assessed using a food frequency questionnaire in 66 patients with AS. Polyunsaturated fatty acids in plasma phospholipids and gluteal adipose tissue were measured using gas chromatography. Disease status was quantified using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein, and proinflammatory cytokines. RESULTS: Diet did not correlate with disease activity assessed by the BASDAI, but there were negative correlations between the dietary intake of long-chain omega-3 fatty acids and ESR (rs = -0.27, p < 0.05). The plasma phospholipid content of arachidonic acid correlated significantly with the BASDAI score (rs = 0.39, p < 0.01). There were correlations between the intake of long-chain omega-3 fatty acids and high-density lipoproteins and serum triglycerides (rs = 0.26 and rs = -0.25, respectively, p < 0.05). CONCLUSION: There was a positive correlation between levels of arachidonic acid in plasma phospholipids and disease activity assessed by BASDAI in patients with AS. A Western diet does not appear to influence this correlation, but seems to affect blood lipids involved in atherogenic processes.

Place, publisher, year, edition, pages
Toronto: Journal of Rheumatology , 2012. Vol. 39, no 2, 327-333 p.
Keyword [en]
rheumatoid arthritis
National Category
Health Sciences
Identifiers
URN: urn:nbn:se:hh:diva-16806DOI: 10.3899/jrheum.110575ISI: 000301008200020PubMedID: 22174215Scopus ID: 2-s2.0-84856540464OAI: oai:DiVA.org:hh-16806DiVA: diva2:467962
Available from: 2011-12-20 Created: 2011-12-20 Last updated: 2017-04-24Bibliographically approved

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