Involvement in competitive soccer is associated with high injury rates (Hägglund, 2007). In an attempt to identify psychosocial injury risk factors, several conceptual models have been developed, for example, Williams and Andersen Stress Injury Model (1998). The aim of the present study was to prospectively examine whether personality variables, stress and coping styles predicted injury occurrence in an elite soccer population. Fifty six soccer players competing in the Swedish Premiere Division completed four questionnaires prior to the start of the competitive season. These included: the Swedish University Scale of Personality, Life Events Survey for Collegiate Athletes, Football Worry Scale, and Brief COPE. Subsequent to the initial data collection, participants completed the Daily Hassle and Uplift Scale, once per week for a 13-week period, and all injuries requiring a minimum 1-day absence from competition were recorded by team physiotherapists. A path analysis was conducted to investigate the influence of specific personality (e.g., somatic trait anxiety), stress and coping variables on injury frequency. Results suggest a model in which daily hassles mediate the relationship between anxiety, negative life event stress, social worry and injury, accounting for 24% of the variance in injury occurrence. This finding supports previous research highlighting the role of anxiety and chronic stress in injury vulnerability (Johnson & Ivarsson, in press). Findings suggest the need for players, coaches and physiotherapists to address both major negative life events and daily hassles in minimizing injury risk. It is also recommended that coaches develop individualized stress monitoring programs for diminishing injury occurrence.