hh.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence
Immunology Unit, Institution for Experimental Medical Research, Lund University, Lund, Sweden.
Immunology Unit, Institution for Experimental Medical Research, Lund University, Lund, Sweden.
Immunology Unit, Institution for Experimental Medical Research, Lund University, Lund, Sweden.
Immunology Unit, Institution for Experimental Medical Research, Lund University, Lund, Sweden.ORCID iD: 0000-0002-3576-2393
Show others and affiliations
2009 (English)In: Oncogene, ISSN 0950-9232, E-ISSN 1476-5594, Vol. 28, no 22, 2238-2243 p.Article in journal (Refereed) Published
Abstract [en]

Somatic stem cells are ultimately responsible for mediating appropriate organ homeostasis and have therefore been proposed to represent a cellular origin of the ageing process-a state often characterized by inappropriate homeostasis. Specifically, it has been suggested that ageing stem cells might succumb to replicative senescence by a mechanism involving the cyclin-dependent kinase inhibitor p16(INK4A). Here, we tested multiple functional and molecular parameters indicative of p16(INK4A) activity in primary aged murine hematopoietic stem cells (HSCs). We found no evidence that replicative senescence accompanies stem cell ageing in vivo, and in line with p16(INK4A) being a critical determinant of such processes, most aged HSCs (>99%) failed to express p16(INK4A) at the mRNA level. Moreover, whereas loss of epigenetically guided repression of the INK4A/ARF locus accompanied replicative senescent murine embryonic fibroblasts, such repression was maintained in aged stem cells. Taken together, these studies indicate that increased senescence as mediated by the p16(INK4A) tumor suppressor has only a minor function as an intrinsic regulator of steady-state HSC ageing in vivo.

Place, publisher, year, edition, pages
Nature Publishing Group, 2009. Vol. 28, no 22, 2238-2243 p.
Keyword [en]
stem cells, hematopoiesis, ageing, senescence
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:hh:diva-15166DOI: 10.1038/onc.2009.94ISI: 000266640300006PubMedID: 19398954Scopus ID: 2-s2.0-67349161638OAI: oai:DiVA.org:hh-15166DiVA: diva2:419602
Available from: 2011-05-27 Created: 2011-05-27 Last updated: 2015-09-21Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Nygren, Jens Martin
In the same journal
Oncogene
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 110 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf