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Small nerve fibre involvement in hypothyroidism: a comparative study using skin punch biopsies and immunostaining
Halmstad University, School of Business and Engineering (SET).
Halmstad University, School of Business and Engineering (SET).
2005 (English)Independent thesis Basic level (degree of Bachelor)Student thesis
Abstract [en]
The purpose of this study was to examine if the disease hypothyroidism affects the nerve fibres in the skin. Hypothyroidism is an under-function of the thyroid gland, which leads to a lowered metabolism in most of the body’s cells (Guyton, 1981). Many hypothyroid patients experience neuropathic type pain in their lower extremities (Massey, 2002). Since neuropathies usually are characterized by a decreased number of nerve fibres (Hsieh et al., 2000), we expected to find a reduced number of nerve fibres in the skin punch biopsies from hypothyroid patients when compared to control group biopsies. Skin punch biopsies from 44 individuals were cut using a cryostat and immunostained with the neuronal marker PGP 9.5. The sections were then viewed in a fluorescence microscope, and all nerve fibres crossing the dermis-epidermis border were quantified. Statistic calculations showed that the patients had significantly less nerve fibres than the control group individuals (p<0.001).
Place, publisher, year, edition, pages
2005.
Keyword [en]
hypothyroidism, nerve fibres, neuropathies, skin punch biopsies, PGP 9.5, fluorescence microscope
Identifiers
URN: urn:nbn:se:hh:diva-13022Local ID: U12092OAI: oai:DiVA.org:hh-13022DiVA: diva2:368191
Uppsok
Life Earth Science
Note
Denna uppsats kan beställas från arkivet / This paper can be ordered from the archive. Kontakta / Contact: arkivet@hh.seAvailable from: 2010-11-09 Created: 2010-11-09Bibliographically approved

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