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Gastric complaints in ankylosing spondylitis: is the silent gut inflammation really silent
Inst för Folkhälsa och Klinisk Medicin, Reumatologi, Universitetssjukhuset, Umeå .
Inst för Folkhälsa och Klinisk Medicin, Reumatologi, Universitetssjukhuset, Umeå.
Halmstad University, School of Social and Health Sciences (HOS), Centre of Research on Welfare, Health and Sport (CVHI).ORCID iD: 0000-0002-9291-9342
2009 (English)Conference paper, Published paper (Refereed)
Abstract [en]

Background: There is strong evidence today of a relation between Ankylosing Spondylitis (AS) and inflammatory changes in the bowel. Since symptoms from the bowel is not a major sign of AS, the inflammatory changes have been considered as “silent”.

Method: The aim of this study was to investigate the frequency and nature of gastric complaints among patients with AS without a diagnosis of inflammatory bowel disease (IBD) and their relation to disease activity, functional status, physical activity and diet by a cross-sectional design. One hundred sixty-five patients with verified diagnosis of AS according to the modified New York criteria, aged 18-70 years received a questionnaire regarding diet, physical activity, gastric complaints and disease status, as measured by BASDAI and BASFI. One hundred twenty-two patients (92 males, 30 females, mean age 50 ±10 years) answered the questionnaire (response rate 74%). Nine patients reported that they had been diagnosed with IBD and were excluded from further analysis, yielding 113 available patients for further analysis.

Result: Forty-Nine percent of the patients reported that they experienced loose stools or diarrhea at least twice a month and 18 % reported loose stools or diarrhea more than two times per week. Furthermore, 29 % of the patients reported gastric pain more than twice a month and 21 % reported problems with constipation or hard stools more than two times per month. Patients with reported gastric pain more often than twice a month had significantly higher disease activity and worse functional status according to BASDAI and BASFI (p=0,003 and p=0,006; respectively). Patients with reported loose stools and diarrhea more than twice a week had a trend towards higher disease activity and worse functional status according to BASDAI and BASFI (p=0,08 and p=0,09; respectively). No significant correlation could be found between medication, including consumption of NSAID and these gastric symptoms.

Conclusion: Gastric pain is common in AS and could be linked to disease activity and functional status. Loose stools and diarrhea are also common in AS, and could also be linked with disease activity or functional status, although to a lesser degree than gastric pain.

Place, publisher, year, edition, pages
2009.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hh:diva-5661OAI: oai:DiVA.org:hh-5661DiVA, id: diva2:351086
Conference
Svenska läkaresällskapets medicinska riksstämma 2009
Available from: 2010-09-13 Created: 2010-09-12 Last updated: 2014-03-05Bibliographically approved

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