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Reconstructing the mitochondrial protein import machinery of Chlamydomonas reinhardtii
Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico.
Institut für Physiologische Chemie, Ludwig-Maximilians-Universität München, Germany .
Halmstad University, School of Business and Engineering (SET), Biological and Environmental Systems (BLESS), Plant Cell Biology: Energy transduction in plant cells.
Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico.
2008 (English)In: Genetics, ISSN 0016-6731, E-ISSN 1943-2631, Vol. 179, no 1, p. 149-155Article in journal (Refereed) Published
Abstract [en]

In Chlamydomonas reinhardtii several nucleus-encoded proteins that participate in the mitochondrial oxidative phosphorylation are targeted to the organelle by unusually long mitochondrial targeting sequences. Here, we explored the components of the mitochondrial import machinery of the green alga. We mined the algal genome, searching for yeast and plant homologs, and reconstructed the mitochondrial import machinery. All the main translocation components were identified in Chlamydomonas as well as in Arabidopsis thaliana and in the recently sequenced moss Physcomitrella patens. Some of these components appear to be duplicated, as is the case of Tim22. In contrast, several yeast components that have relatively large hydrophilic regions exposed to the cytosol or to the intermembrane space seem to be absent in land plants and green algae. If present at all, these components of plants and algae may differ significantly from their yeast counterparts. We propose that long mitochondrial targeting sequences in some Chlamydomonas mitochondrial protein precursors are involved in preventing the aggregation of the hydrophobic proteins they carry.

Place, publisher, year, edition, pages
Austin, Tex.: The Genetics Society, 2008. Vol. 179, no 1, p. 149-155
Keywords [en]
Chlamydomonas, Mitochondrial protein, Cytochrome-C-Oxidase, Intracellular gene-transfer, Iron-sulfur protein, Membrane-proteins, Intermembrance space, Yeast mitochondria, Export machinery, Outer-membrane, Inner membrane, CDNA sequence
National Category
Genetics
Identifiers
URN: urn:nbn:se:hh:diva-1879DOI: 10.1534/genetics.108.087965ISI: 000256312000014PubMedID: 18493047Scopus ID: 2-s2.0-52049084400Local ID: 2082/2274OAI: oai:DiVA.org:hh-1879DiVA, id: diva2:239097
Available from: 2008-09-10 Created: 2008-09-10 Last updated: 2018-03-23Bibliographically approved

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Franzén, Lars-Gunnar

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