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Effects of long-term administration of cancer-promoting substances on oral subepithelial mast cells in the rat
Department of Surgical Sciences, Uppsala University Hospital, Sweden.
Dept. of Basic Oral Sciences Unit, Odontology, Karolinska Institute, Stockholm, Sweden.
Department of Surgery, Angelholm Hospital, Sweden.
Dept. of Oral/Maxillofacial Surgery, Faculty of Odontology, Goteborg University, Sweden.
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2002 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 22, no 5, p. 2623-2627Article in journal (Refereed) Published
Abstract [en]

The role of oral subepithelial mast cells in the defence against tumours is a matter of controversy. The effect of established and suggested carcinogens, such as the carcinogen 4-nitroquinoline-N-oxide (4-NQO) and Herpes simplex virus type 1 (HSV-1), in combination with oral snuff on lower lip subepithelial mast cells (MC) was studied in rats. The rats were exposed to prolonged use of oral snuff. The test substances were administered in a surgically created canal in the lower lip of the rats. There were 15 rats in each test group and 10 rats in the control group. The amount of countable subepithelial mast cells decreased significantly when the rat oral mucosa was exposed to the oral carcinogen 4-NQO but the effect of oral snuff and HSV-1 infection was weak. Our findings suggest that mast cells play a role in immunological cell defence against chemical carcinogens. Further studies are needed to clarify the mechanisms.

Place, publisher, year, edition, pages
Athens: Hellenic Anticancer Institute , 2002. Vol. 22, no 5, p. 2623-2627
Keywords [en]
Vertebrata, Mammalia, Rodentia, Virus, Herpesviridae, Alphaherpesvirinae, Rat, Herpesvirus hominis 1, Subepithelial cell, Carcinogen, Carcinogenesis, Malignant tumor, 4-nitroquinoline-N-oxide, Mast cell, Oral mucosa, Tumour development
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:hh:diva-1525ISI: 000180132200014PubMedID: 12529973Scopus ID: 2-s2.0-0036765652Local ID: 2082/1905OAI: oai:DiVA.org:hh-1525DiVA, id: diva2:238743
Available from: 2008-06-12 Created: 2008-06-12 Last updated: 2018-03-23Bibliographically approved

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CiteExportLink to record
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