hh.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Steroid receptor expression and morphology in provoked vestibulodynia
Division of Obstetrics and Gynecology, Department of Clinical Sciences, Danderyd Hospital, Stockholm.
Division of Reproductive Endocrinology, Department of Woman and Child Health, Karolinska Institutet, Stockholm.
Division of Reproductive Endocrinology, Department of Woman and Child Health, Karolinska Institutet, Stockholm.
Halmstad University, School of Business and Engineering (SET), Biological and Environmental Systems (BLESS), Biomechanics and Biomedicine.
Show others and affiliations
2008 (English)In: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 198, no 3, p. 311.e1-311.e6Article in journal (Refereed) Published
Abstract [en]

Objective: This study was undertaken to survey the steroid receptor expression and morphology in the vulvar vestibular mucosa in women with provoked vestibulodynia.

Study Design: Fourteen patients and 25 controls without oral contraceptives were included. Vestibular biopsy specimens were obtained and analyzed by using immunohistochemistry, followed by computerized image analysis of estrogen receptors greek small letter alpha and β, progesterone receptors A and B, glucocorticoid receptor, androgen receptor, and the proliferation marker Ki67. The morphology was estimated by measuring 4 parameters in the epithelium.

Results: There was a significantly higher expression of estrogen receptor greek small letter alpha in both the epithelium (P = .04) and the stroma (P = .02) in the patient specimens compared with the controls. There were no significant differences in the other analyses performed.

Conclusion: There is an increased expression of estrogen receptor greek small letter alpha in the vestibular mucosa but the epithelial morphology seems unaffected in women with provoked vestibulodynia. Further studies regarding plausible associations to neurogenic inflammation are needed.

Place, publisher, year, edition, pages
St. Louis: C.V. Mosby , 2008. Vol. 198, no 3, p. 311.e1-311.e6
Keywords [en]
Estrogen receptor, Morphology, Provoked vestibulodynia, Vulvar mucosa
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:hh:diva-1327DOI: 10.1016/j.ajog.2007.09.041ISI: 000253730000027PubMedID: 18177837Scopus ID: 2-s2.0-39649088672Local ID: 2082/1706OAI: oai:DiVA.org:hh-1327DiVA, id: diva2:238545
Available from: 2008-04-16 Created: 2008-04-16 Last updated: 2018-03-23Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Hilliges, Marita

Search in DiVA

By author/editor
Hilliges, Marita
By organisation
Biomechanics and Biomedicine
In the same journal
American Journal of Obstetrics and Gynecology
Obstetrics, Gynecology and Reproductive Medicine

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 51 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf