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Active "itch fibers" in chronic pruritus
Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany; Department of Physiology and Experimental Pathophysiology, University of Erlangen, Germany.
Department of Basic Oral Sciences , Karolinska Institute, Stockholm, Sweden.
Department of Clinical Neurophysiology, University of Uppsala, Sweden.
Department of Neurology and Clinical Neurophysiology, Rikshospitalet, University of Oslo, Norway.
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2003 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 61, no 4, p. 564-566Article in journal (Refereed) Published
Abstract [en]

An itch-specific neuronal pathway was recently discovered in healthy humans and animals. Here the authors report that activity in this specific pathway coincides with itch under pathophysiologic conditions in a patient with chronic pruritus. Microneurographic recordings from the symptomatic area revealed spontaneous activity in six single C-fiber afferents that had the characteristic features of "itch fibers." Itch may be caused by activity in a specific subpopulation of C-fiber afferents.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins , 2003. Vol. 61, no 4, p. 564-566
Keyword [en]
Pruritus, Itch, Fibers
National Category
Neurology
Identifiers
URN: urn:nbn:se:hh:diva-551ISI: 000184953900032PubMedID: 12939442Scopus ID: 2-s2.0-0042388500Local ID: 2082/892OAI: oai:DiVA.org:hh-551DiVA, id: diva2:237730
Available from: 2007-03-03 Created: 2007-03-03 Last updated: 2018-03-23Bibliographically approved

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