Being injured is often associated with undesirable consequences, such as negative emotions, pain, and increased risk of career termination. When considered alongside high risk of injuries within sport, sport injury prevention should be considered paramount in any sport. This chapter aims to provide an overview of the biopsychosocial risk factors associated with sport injury. The chapter outlines the existing theoretical models explaining biopsychosocial injury risk factors, summarizes the most common biopsychosocial sport injury risk factors, and synthesizes research evidence in support of existing injury prevention programs. © 2024 Taylor and Francis.