Information Systems (IS) research has extensively studied change in relation to digitalization. However, less attention has been paid to both individual and organizational change from a learning perspective. There is a need for a deeper understanding of how changes are fostered and how and why learning in the circumstances of digital practices occurs. This interdisciplinary systematic review shows how workplace learning has been addressed within IS, bringing together workplace learning theories and the field of IS. The results show that research on the role of knowledge in IS tends to rely on established and conventional theories without explicitly articulating the learning aspects. We call for more IS research that explicitly addresses digital change as learning. This paper provides a research agenda via three research directions for IS researchers interested in work and learning, aiming for a theoretical discussion to advance our field. © 2022 IEEE Computer Society. All rights reserved.