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Long-term outcome after closure of an atrial shunt in patients aged 60 years or older with ischemic stroke: A nationwide, registry-based, case-control study
Center for Adults with Congenital Heart Disease (ACHD), Sahlgrenska University Hospital/Östra, Gothenburg, Sweden; Institute of Medicine, Department of Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.ORCID iD: 0000-0002-0547-5369
Center for Adults with Congenital Heart Disease (ACHD), Sahlgrenska University Hospital/Östra, Gothenburg, Sweden; Institute of Medicine, Department of Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
School of Business, Economics and Law, University of Gothenburg, Gothenburg, Sweden.ORCID iD: 0000-0002-7299-6842
Center for Adults with Congenital Heart Disease (ACHD), Sahlgrenska University Hospital/Östra, Gothenburg, Sweden; Institute of Medicine, Department of Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
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2023 (English)In: International Journal of Cardiology Congenital Heart Disease, E-ISSN 2666-6685, Vol. 11, article id 100438Article in journal (Refereed) Published
Abstract [en]

Background: According to the current guidelines, evidence of the effects of transcatheter closure in patients aged ≥60 years with an atrial shunt and cryptogenic stroke is still limited. Methods: Using Swedish health registries, patients aged ≥60 years who had previously developed a cryptogenic cerebrovascular event and undergone transcatheter closure were identified. Patients with atrial fibrillation were excluded, and the remaining patients were propensity score-matched with patients of the same age and risk profile who had only undergone medical treatment and with controls from the general population. They were then followed up until 2017 (mean period of 7.1 ±3.9 years). Results: In total, 100 patients of the intervention group were matched with 100 patients of the medical treatment group and with 100 controls and followed up. The hazard ratio for a recurrent ischemic stroke in the intervention group compared with the medical treatment group was 0.8 (95% confidence interval, 0.3–2.1), and that compared with the controls was 2.3 (95% confidence interval, 0.6–8.9). Atrial fibrillation occurred at the same rate in the two treatment groups (odds ratio, 0.8; 95% confidence interval, 0.4–1.7). However, patients in the intervention group developed vascular disease at a lower rate (odds ratio, 0.5; 95% confidence interval, 0.25–0.85). Conclusions: Patients aged ≥60 years with cryptogenic stroke may undergo transcatheter closure of an atrial shunt after thorough screening for other potential causes of stroke. The incidence of vascular disease seems to be mitigated in these patients relative to medically treated patients. © 2023 The Authors. Published by Elsevier B.V.

Place, publisher, year, edition, pages
Amsterdam: Elsevier, 2023. Vol. 11, article id 100438
Keywords [en]
Atrial shunt, Cryptogenic stroke, Advanced age, Transcatheter intervention, Cerebrovascular event
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:hh:diva-51962DOI: 10.1016/j.ijcchd.2022.100438OAI: oai:DiVA.org:hh-51962DiVA, id: diva2:1811280
Funder
Swedish Heart Lung Foundation, 20,090,724 & 20180644
Note

Funding: This work was supported by the Swedish state under an agreement between the Swedish government and county councils, the ALF agreement (Grant Number: 236,611), and the Swedish Heart-Lung Foundation (Grant Numbers: 20,090,724 and 20180644).

Available from: 2023-11-12 Created: 2023-11-12 Last updated: 2023-11-22Bibliographically approved

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Papadopoulos, Savvas

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Karagianni, AlexiaPapadopoulos, Savvas
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