Irritable Bowel Syndrome (IBS) is a common condition in the family of functional gastrointestinal disorders where patients suffer from abdominal pain and irregular bowel habits. The relationship between physical activity and IBS has not been well explored particularly in the area of physical activity’s role in mitigating the risk and improving the symptoms.In this systematic review, a comprehensive search was done on PubMed and Science Direct in order to find articles that help understand the relationship between physical activity levels and IBS in two folds; first, if there is a correlation between low physical activity levels and IBS, and second, if IBS patients would attain benefits on their symptoms and quality of life by increasing their physical activity levels.15 articles were found matching the inclusion criteria and were reviewed whereby relevant data has been extracted and synthesized; and after being critically analyzed, it transpires that the evidence on low physical activity level as a risk factor in IBS is not conclusive and requires future studies that adopt standard and streamlined methodologies for diagnosing IBS and assessing physical activity levels. Prospective studies in particular are recommended for that purpose.On the other hand, for those who are already diagnosed with IBS, there is an important evidence that increasing physical activity levels leads to lighter symptoms and remarkable improvements in quality of life which proposes physical activity as a primary treatment option in IBS patients. Nevertheless, in order to reach a more comprehensive understanding and a greater level of certainty, future research is needed on the effects of resistance training as well as the responses of each IBS sub-type to increased physical activity.