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Clinical characteristics and mortality of patients with heart failure in Southern Sweden from 2013 to 2019: a population-based cohort study
Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Capio Vårdcentral Halmstad, Capio AB, Halmstad, Sweden.ORCID iD: 0000-0002-2523-3148
Halmstad University, School of Information Technology.ORCID iD: 0000-0001-5688-0156
University of Oslo, Oslo, Norway; Novartis Norge AS, Oslo, Norway.
Halmstad University, School of Information Technology.ORCID iD: 0000-0003-1145-4297
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2022 (English)In: BMJ Open, E-ISSN 2044-6055, Vol. 12, no 12, article id e064997Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To describe clinical characteristics and prognosis related to heart failure (HF) phenotypes in a community-based population by applying a novel algorithm to obtain ejection fractions (EF) from electronic medical records. DESIGN: Retrospective population-based cohort study. SETTING: Data were collected for all patients with HF in Southwest Sweden. The region consists of three acute care hospitals, 40 inpatient wards, 2 emergency departments, 30 outpatient specialty clinics and 48 primary healthcare. PARTICIPANTS: 8902 patients had an HF diagnosis based on the International Classification of Diseases, Tenth Revision during the study period. Patients <18 years as well as patients declining to participate were excluded resulting in a study population of 8775 patients. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome measure was distribution of HF phenotypes by echocardiography. The secondary outcome measures were 1 year all-cause mortality and HR for all-cause mortality using Cox regression models. RESULTS: Out of 8775 patients with HF, 5023 (57%) had a conclusive echocardiography distributed into HF with reduced EF (35%), HF with mildly reduced EF (27%) and HF with preserved EF (38%). A total of 43% of the cohort did not have a conclusive echocardiography, and therefore no defined phenotype (HF-NDP). One-year all-cause mortality was 42% within the HF-NDP group and 30% among those with a conclusive EF. The HR of all-cause mortality in the HF-NDP group was 1.27 (95% CI 1.17 to 1.37) when compared with the confirmed EF group. There was no significant difference in survival within the HF phenotypes. CONCLUSIONS: This population-based study showed a distribution of HF phenotypes that varies from those in selected HF registries, with fewer patients with HF with reduced EF and more patients with HF with preserved EF. Furthermore, 1-year all-cause mortality was significantly higher among patients with HF who had not undergone a conclusive echocardiography at diagnosis, highlighting the importance of correct diagnostic procedure to improve treatment strategies and outcomes. © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Place, publisher, year, edition, pages
London: BMJ Publishing Group Ltd, 2022. Vol. 12, no 12, article id e064997
Keywords [en]
echocardiography, epidemiology, heart failure
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:hh:diva-49134DOI: 10.1136/bmjopen-2022-064997ISI: 000920894900022PubMedID: 36526318Scopus ID: 2-s2.0-85144588945OAI: oai:DiVA.org:hh-49134DiVA, id: diva2:1724755
Note

Funding: Novartis Sweden AB

Available from: 2023-01-09 Created: 2023-01-09 Last updated: 2023-08-28Bibliographically approved

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Ashfaq, AwaisOhlsson, Mattias

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