Blockchain is a buzzword today, and its application is daily increasing. Recently, literature has proposed the new concept of the Internet of Value (IoV), which refers to a view of the Internet as a means where value is transferred as easily, cheaply and reliably as data is now transferred. The ever-growing interest in Blockchain research and practice has given rise to disorganized knowledge around its application, especially for business purposes. To qualitatively assess this gap, we conducted a literature review by investigating a final number of 169 original contributions produced in the last half-decade. The insights have been analysed and systematized considering the possible contribution of the Blockchain application to the Internet of Value, to shed light on Blockchain opportunities in business value creation regarding five basic topics: Blockchain exploitation in the energy sector; Blockchain exploitation in healthcare; Blockchain exploitation in supply chain management (SCM); Blockchain exploitation in industrial marketing; and Blockchain exploitation in data privacy protection. © 2022 International Management Institute, New Delhi.