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Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease
Göteborg University, Göteborg, Sweden.
Lund University, Lund, Sweden.
Lund University, Lund, Sweden.
Lund University, Lund, Sweden.ORCID iD: 0000-0001-7790-8197
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2004 (English)In: American Journal of Pathology, ISSN 0002-9440, E-ISSN 1525-2191, Vol. 164, no 3, p. 959-966Article in journal (Refereed) Published
Abstract [en]

Relapsing polychondritis is an autoimmune disease that affects cartilage in the ear, nose, and respiratory tract. A pathogenic immune response has been proposed and antibodies to several cartilage proteins are detected in sera from these patients. To investigate the role of the humoral immune response in relapsing polychondritis, we used the matrilin-1-induced relapsing polychondritis model. Mice deficient of B cells (muMT) and mice congenic at the complement factor 5, were immunized with matrilin-1, a cartilage-specific protein mainly detected in the tracheal cartilage. To investigate the binding properties and tissue selection of matrilin-1-specific antibodies we produced matrilin-1-specific B-cell hybridomas. Although 83% of the micro MT heterozygous mice developed respiratory distress and erosive chondritis in the respiratory tract, none of the B-cell-deficient mice were susceptible to disease. In addition, we show that complement factor 5 is important for the induction of matrilin-1-induced relapsing polychondritis. Monoclonal matrilin-1-specific antibodies injected into neonatal mice bound specifically to cartilage of the respiratory tract and adult B-cell-deficient mice injected with the same antibodies developed erosive chondritis in the respiratory tract. We conclude that relapsing polychondritis can be mediated by a pathway involving tissue-specific antibodies and complement activation.

Place, publisher, year, edition, pages
New York, NY: Elsevier, 2004. Vol. 164, no 3, p. 959-966
Keywords [en]
Animals, Animals, Newborn, *Antibodies, Autoimmune Diseases/immunology/pathology, B-Lymphocytes/*immunology, Cartilage/immunology/pathology, Complement C5/*immunology, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Extracellular Matrix Proteins/*immunology/toxicity, Glycoproteins/*immunology/toxicity, Hybridomas, Matrilin Proteins, Mice, Mice, Congenic, Polychondritis, Relapsing/chemically induced/*immunology, Respiratory System/immunology
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:hh:diva-48813DOI: 10.1016/S0002-9440(10)63183-5ISI: 000189164300021PubMedID: 14982849Scopus ID: 2-s2.0-1242271332OAI: oai:DiVA.org:hh-48813DiVA, id: diva2:1719112
Available from: 2022-12-14 Created: 2022-12-14 Last updated: 2023-02-16Bibliographically approved

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Nandakumar, Kutty Selva

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