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Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen
Lund University, Lund, Sweden.
Lund University, Lund, Sweden.ORCID iD: 0000-0001-7790-8197
Uppsala Biomedical Center, IMBIM, Uppsala, Sweden.
Lund University, Lund, Sweden.
2005 (English)In: Arthritis Research & Therapy , E-ISSN 1478-6362, Vol. 7, p. R1148-R1157Article in journal (Refereed) Published
Abstract [en]

Antibodies against type II collagen (CII) are important in the development of collagen-induced arthritis (CIA) and possibly also in rheumatoid arthritis. We have determined the fine specificity and arthritogenicity of the antibody response to CII in chronic relapsing variants of CIA. Immunization with rat CII in B10.Q or B10.Q(BALB/cxB10.Q)F2 mice induces a chronic relapsing CIA. The antibody response to CII was determined by using triple-helical peptides of the major B cell epitopes. Each individual mouse had a unique epitope-specific response and this epitope predominance shifted distinctly during the course of the disease. In the B10.Q mice the antibodies specific for C1 and U1, and in the B10.Q(BALB/cxB10.Q)F2 mice the antibodies specific for C1, U1 and J1, correlated with the development of chronic arthritis. Injection of monoclonal antibodies against these epitopes induced relapses in chronic arthritic mice. The development of chronic relapsing arthritis, initially induced by CII immunization, is associated with an arthritogenic antibody response to certain CII epitopes.

Place, publisher, year, edition, pages
2005. Vol. 7, p. R1148-R1157
Keywords [en]
Animals, Antibodies, Monoclonal/immunology/toxicity, Arthritis, Experimental/*immunology, Autoantibodies/*immunology, Autoantigens/*immunology, Collagen Type II/*immunology, Crosses, Genetic, Disease Models, Animal, Disease Progression, Female, Immunization, Passive, Immunodominant Epitopes/*immunology, Male, Mice, Mice, Inbred BALB C, Rats, Recurrence
National Category
Immunology in the medical area Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:hh:diva-48819DOI: 10.1186/ar1800PubMedID: 16207332ISBN: 1478-6362 (Electronic) 1478-6354 (Print) 1478-6354 (Linking) OAI: oai:DiVA.org:hh-48819DiVA, id: diva2:1719103
Available from: 2022-12-14 Created: 2022-12-14 Last updated: 2024-07-04Bibliographically approved

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Nandakumar, Kutty Selva

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