Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules 2006 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 176, no 3, p. 1525-1533Article in journal (Refereed) Published

Abstract [en]

In both collagen-induced arthritis (CIA) and rheumatoid arthritis, T cells recognize a galactosylated peptide from type II collagen (CII). In this study, we demonstrate that the CII259-273 peptide, galactosylated at lysine 264, in complex with Aq molecules prevented development of CIA in mice and ameliorated chronic relapsing disease. In contrast, nonglycosylated CII259-273/Aq complexes had no such effect. CIA dependent on other MHC class II molecules (Ar/Er) was also down-regulated, indicating a bystander vaccination effect. T cells could transfer the amelioration of CIA, showing that the protection is an active process. Thus, a complex between MHC class II molecules and a posttranslationally modified peptide offers a new possibility for treatment of chronically active autoimmune inflammation such as rheumatoid arthritis. © 2006 by The American Association of Immunologists, Inc.

Place, publisher, year, edition, pages

Rockville, MD: American Association of Immunologists , 2006. Vol. 176, no 3, p. 1525-1533

Keywords [en]

Animals, Arthritis, Experimental/chemically induced/immunology/*prevention & control, Bystander Effect/immunology, Cattle, Chronic Disease, Collagen Type II/immunology/metabolism/*therapeutic use, Galactose/metabolism, Glycosylation, Histocompatibility Antigens Class II/immunology/metabolism/*therapeutic use, Hybridomas/immunology/metabolism, Immunodominant Epitopes/immunology/metabolism/therapeutic use, *Immunotherapy, Active, Lymphocyte Activation/drug effects/immunology, Male, Mice, Mice, Inbred BALB C, Multiprotein Complexes/immunology/metabolism/*therapeutic use, Peptides/immunology/metabolism/*therapeutic use, Rats, Solubility, T-Lymphocytes/drug effects/immunology, Vaccines/immunology/*therapeutic use

National Category

Immunology in the medical area Rheumatology and Autoimmunity

Identifiers

URN: urn:nbn:se:hh:diva-48829DOI: 10.4049/jimmunol.176.3.1525ISI: 000234766600030PubMedID: 16424181Scopus ID: 2-s2.0-31144450506OAI: oai:DiVA.org:hh-48829DiVA, id: diva2:1719046

Available from: 2022-12-14 Created: 2022-12-14 Last updated: 2023-02-16Bibliographically approved

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Nandakumar, Kutty Selva

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