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An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes
Lund University, Lund, Sweden.
Lund University, Lund, Sweden; Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0001-7790-8197
Copenhagen University, Copenhagen, Denmark.
Lund University, Lund, Sweden; Karolinska Institutet, Stockholm, Sweden.
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2011 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 235, no 1-2, p. 40-47Article in journal (Refereed) Published
Abstract [en]

A locus on mouse chromosome 16 was found to control experimental autoimmune encephalomyelitis (EAE) in studies using congenic mice. Genes within the congenic region control encephalomyelitis but not arthritis, indicating the presence of genes in this region involved in central nervous system (CNS) specific mechanisms. Flow cytometry analyses of expression of two candidate genes within the linked locus, Cd200 and Btla, demonstrated a significantly lower expression of CD200 on CD4+ T cells and higher expression of BTLA on B cells from the congenic mice. These results suggest that genes within this mouse chromosome 16 locus specifically control EAE development possibly through immune-regulatory cell-surface molecules. © 2011 Elsevier B.V.

Place, publisher, year, edition, pages
Amsterdam: Elsevier, 2011. Vol. 235, no 1-2, p. 40-47
Keywords [en]
BTLA, CD200, Experimental autoimmune encephalomyelitis (EAE), Genetics
National Category
Neurology
Identifiers
URN: urn:nbn:se:hh:diva-48865DOI: 10.1016/j.jneuroim.2011.04.001ISI: 000292665000006PubMedID: 21543122Scopus ID: 2-s2.0-79958019186OAI: oai:DiVA.org:hh-48865DiVA, id: diva2:1719002
Note

Funding text: We thank I. Bohlin for help with animal care and D. Poulsen for genotyping. This work was supported by grants from the LEO Pharma Foundation, Denmark; The Swedish Association of Persons with Neurological Disablities; The Crafoord Foundation, Sweden; Bibbi and Niels Jensens Foundation, Sweden; The Novo Nordisk Foundation, Denmark; the Swedish Research Council, the Swedish strategic research foundation, and EU projects (Masterswitch HEALTH-F2-2008-223404).

Available from: 2022-12-14 Created: 2022-12-14 Last updated: 2023-02-17Bibliographically approved

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Nandakumar, Kutty Selva

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