hh.sePublications
Planned maintenance
A system upgrade is planned for 13/12-2023, at 12:00-13:00. During this time DiVA will be unavailable.
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Polymeric cryogels are biocompatible, and their biodegradation is independent of oxidative radicals
Indian Institute of Technology Kanpur, Kanpur, India; Karolinska Institute, Stockholm, Sweden.
Karolinska Institute, Stockholm, Sweden.
Karolinska Institute, Stockholm, Sweden; University of Arkansas for Medical Sciences, Little Rock, United States.ORCID iD: 0000-0001-7790-8197
Indian Institute of Technology Kanpur, Kanpur, India.
2014 (English)In: Journal of Biomedical Materials Research. Part A, ISSN 1549-3296, E-ISSN 1552-4965, Vol. 102, no 10, p. 3409-3418Article in journal (Refereed) Published
Abstract [en]

Biocompatibility and in vivo degradation are two important characteristics of cell scaffolds. We evaluated these properties for four different polymeric macroporous cryogels, polyvinylcaprolactam, polyvinyl alcohol-alginate-bioactive glass composite, polyhydroxyethylmethacrylate-gelatin (pHEMA-gelatin), and chitosan-agarose-gelatin in mice. All the cryogels were synthesized at subzero temperature and were implanted subcutaneously in C57Bl/10.Q inbred mice. Both local and systemic toxicities were negligible as determined by serum tumor necrosis factor α analysis and histology of surrounding tissues nearby the implants. Complete integration of cryogels into the surrounding tissues with neovascular formation was evident in all the mice. At the implantation site, massive infiltration of macrophages and few dendritic cells were observed but neutrophils and mast cells were clearly absent. Macrophage infiltrations were observed even inside the pores of cryogel implants. To ascertain whether oxidative radicals are involved in the cryogel degradation, we implanted these gels in mice deficient for reactive oxygen species (ROS) production. Rapid gel degradation was observed in the absence of ROS, and there was no significant difference in the biodegradation of these cryogels between ROS sufficient and deficient mice thereby excluding any major role for ROS in this process. Thus, we demonstrate the biocompatibility and ROS-independent biodegradable properties of cryogels that could be useful for tissue-specific tissue engineering applications. © 2013 Wiley Periodicals, Inc. 

Place, publisher, year, edition, pages
Hoboken, NJ: John Wiley & Sons, 2014. Vol. 102, no 10, p. 3409-3418
Keywords [en]
biocompatibility, cryogel, degradation, host tissue response, toxicity
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:hh:diva-48412DOI: 10.1002/jbm.a.35013ISI: 000341130400008PubMedID: 24142798Scopus ID: 2-s2.0-8489654419OAI: oai:DiVA.org:hh-48412DiVA, id: diva2:1703157
Available from: 2022-10-12 Created: 2022-10-12 Last updated: 2022-10-26Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Nandakumar, Kutty Selva

Search in DiVA

By author/editor
Nandakumar, Kutty Selva
In the same journal
Journal of Biomedical Materials Research. Part A
Biomaterials Science

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 2 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf