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The autoantibody response to cyclic citrullinated collagen type II peptides in rheumatoid arthritis
Southern Medical University, Guangzhou, China; Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Southern Medical University, Guangzhou, China.
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2019 (English)In: Rheumatology, ISSN 1462-0324, E-ISSN 1462-0332, Vol. 58, no 9, p. 1623-1633Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: The detection of anti-citrullinated peptide antibodies (ACPAs) is a serological hallmark of RA. Autoantibodies reactive with collagen type II (CII) are present in RA sera and synovial fluid and are potentially pathogenic. Here, we investigate the prevalence and specificity of the autoantibody responses to defined citrullinated cyclic peptides derived from CII in a China RA cohort.

METHODS: Using bead-based multiplex assay, we examined the presence of autoantibodies binding to 54 cyclic 17-mer citrullinated CII peptides, encompassing all citrullinate epitopes in CII, and the corresponding unmodified peptides in 415 RA patients, in addition to 304 patients with OA. Furthermore, the autoantibody responses to a selected set of 10 cyclic citrullinated peptides were also examined in 203 healthy individuals.

RESULTS: Autoantibody responses to cyclic citrullinated CII peptides were higher in RA patients as compared with OA patients or healthy individuals, whereas little or negligible antibody responses to cyclic unmodified CII peptides were observed. Interestingly, several novel citrullinated CII epitopes were identified. Antibodies to these novel citrullinated CII epitopes showed not only substantial overlapping reactivities but also had unique specificities.

CONCLUSION: We found a high prevalence of autoantibodies against cyclic citrullinated CII in the sera of patients in a China RA cohort. The present study revealed heterogeneous binding patterns against novel citrullinated CII epitopes, which may help to stratify RA patients into different subgroups.

Place, publisher, year, edition, pages
Oxford: Oxford University Press, 2019. Vol. 58, no 9, p. 1623-1633
Keywords [en]
anti-citrullinated peptide antibody, collagen type II, osteoarthritis, rheumatoid arthritis
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:hh:diva-48367DOI: 10.1093/rheumatology/kez073ISI: 000493383000016PubMedID: 30892636Scopus ID: 2-s2.0-85072057775OAI: oai:DiVA.org:hh-48367DiVA, id: diva2:1702793
Note

This study was supported by the introduced innovative R&D team of Guangdong (201001Y04675344), a grant from Dongguan city and a grant (C1034211) from SMU, China. In addition, the Swedish Strategic Science Foundation, Knut and Alice Wallenberg Foundation and Swedish Research Council also supported this study.

Available from: 2022-10-11 Created: 2022-10-11 Last updated: 2022-10-20Bibliographically approved

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Nandakumar, Kutty Selva

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