A Microfluidic Platform for Synchrotron X-ray Studies of ProteinsShow others and affiliations
2021 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]
New tools are needed to allow for complex protein dynamics studies, especially to study proteins in their native states. In the AdaptoCell project a microfluidic platform for academic and industrial users at MAX IV Laboratory is being developed. MAX IV is a Swedish national laboratory providing brilliant synchrotron X-rays for research. Due to the high photon flux, sensitive samples such as proteins are prone to rapid radiation damage; thus, it is advantageous to have the liquid sample underflow to refresh the sample continuously. This, in combination with small volumes, makes microfluidics a highly suitable sample environment for protein studies at MAX IV. The AdaptoCell platform is being integrated at three beamlines:Balder (X-ray absorption/emission spectroscopy), CoSAXS (small angle x-ray scattering) and Micromax (serial synchrotron crystallography). Currently, the platform is fully available atBalder, under commissioning at CoSAXS and being developed for MicroMAX.
Place, publisher, year, edition, pages
2021.
National Category
Structural Biology
Research subject
Smart Cities and Communities
Identifiers
URN: urn:nbn:se:hh:diva-47661OAI: oai:DiVA.org:hh-47661DiVA, id: diva2:1686161
Conference
24th Swedish Conference on Macromolecular Structure and Function (SWEPROT), 20-23 June, 2021
Funder
Swedish Foundation for Strategic Research, ITM-03752022-08-082022-08-082022-08-23Bibliographically approved